Bi(NO3)3•5H2O-catalyzed Mannich Reaction: A Potent Catalyst for Synthesis of β-Aminocarbonyl Compounds

Year 2019, Volume: 6 Issue: 3, 433 - 438, 20.10.2019

Hasniye Yaşa , Kübra Demir

https://doi.org/10.18596/jotcsa.605641

Cited By: 2

Abstract

Biologically active
compounds containing nitrogen, natural molecules and drugs are important for
organic synthesis. Mannich reaction is one of the most common methods used for
the synthesis of these compounds. Bi(NO₃)₃ was used as an
efficient catalyst for the one-pot three-component Mannich reactions of ketones
with different aromatic amines and aromatic aldehydes at room temperature. It
is a good method to prepare β-amino carbonyl compounds in excellent yield. The
high efficiency using simple starting materials and a catalytic amount of a
reusable catalyst is especially noteworthy.

Keywords

Mannich reaction, One-pot synthesis, Bismuth (III) nitrate

Supporting Institution

Scientific Research Projects Coordination Unit of Istanbul University

Project Number

57459

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