Comparison of Antioxidant Activities of Mono-, Di- and Tri-substituted Coumarins

Year 2020, Volume: 7 Issue: 1, 87 - 96, 15.02.2020

Hülya Çelik Onar Hasniye Yaşa Oktay Sin

https://doi.org/10.18596/jotcsa.624265

Cited By: 3

Abstract

In this study; Numerous
coumarin compounds were synthesized by Pechmann and Knoevenagel methods, and
the substitution of the formyl group was provided by the Duff reaction. The IR
spectras and melting points of the synthesized compounds were compared with the
literature values. Also confirmed by GC/MS analysis. And the synthesized
coumarin derivatives were compared in terms of antioxidant activity according
to DPPH and Cuprac methods. The main aim of the study is to determine the
effects of substituents on antioxidant activity.

Keywords

Coumarin, Pechmann reaction, Knoevenagel reaction, Duff reaction, Cuprac method, DDPH method

Supporting Institution

Research Fund of The İstanbul University-Cerrahpaşa.

Project Number

FYL-2017-23395.

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