Research Article
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Year 2020, Volume 1, Issue 2, 40 - 45, 01.08.2020
https://doi.org/10.37662/jpt.2020.5

Abstract

References

  • [1] Lee HY, Stieger M, Yawalker N, Kakeda M. Cytokines and chemokines in irritant contact dermatitis. Mediators Inflamm. (2013); 916497. https://doi.org/10.1155/2013/916497
  • [2] Ayanlowo O, Olumide Y. Routine patch testing in a dermatology clinic of a teaching hospital in Nigeria. Nig Q J Hosp Med. (2007); 17 (4): 160-164. https://doi.org/10.4314/nqjhm.v17i4.12699
  • [3] Draelos ZD. The science behind skin care: Cleansers. J Cosmet Dermatol. (2018); 17(1): 8-14. https://doi.org/14.10.1111/jocd.12469
  • [4] Schmid-Wendtner MH, Korting HC. The pH of the ski surface and its impact on the barrier function. Skin Pharmacol Physiol. (2006); 19 (6): 296-302. https://doi.org/10.1159/00009467
  • [5] Korting HC, Kober M, Mueller M, Braun-Falco O. Influence of repeated washings with soap and synthetic detergents on pH and resident flora of the skin of forehead and forearm. Results of a cross- over trial in health probationers. Acta Derm Venereol. (1987); 67: 41- 47.
  • [6] Mukhopadhyay P. Cleansers and their role in various dermatological disorders. Indian J Dermatol. (2011); 56: 2-6. https://doi.org/10.4103/0019-5154.77542
  • [7] Tyebkhan G. A study on the pH of commonly used soaps/cleansers available in the Indian market. Indian J Dermatol Venereol Leprol. (2001); 67: 290-291.
  • [8] Fiszenson-Albala F, Auzerie V, Mahe E, Farinotti R, Durand-Stocco C, Crickx B, Descamps V. A 6-month prospective survey of cutaneous drug reactions in a hospital setting. British J Derm. (2003); 149(5): 1018-1022. https://doi.org/10.1111/j.1365-2133.2003.05584.x
  • [9] Breneman DL, Hanifin J, Berge CA, Keswick BH, Neumann PB. The effect of antibacterial soap with 1.5% triclocarban on Staphylococcus aureus in patients with atopic dermatitis. Cutis. (2000); 66(4): 296- 300.
  • [10] Mark BJ, Slavin RG. Allergic contact dermatitis. Med Clin N Am. (2006); 90: 169-185. https://doi.org/10.1016/j.mcna.2005.08.008
  • [11] Ilomuanya MO, Adebona AC, Wang W, Sowemimo A, Eziegbo CL, Silva BO, Adeosun SO, Joubert E, De Beer D. Development and characterization of collagen-based electrospun scaffolds containing silver sulphadiazine and Aspalathus linearis extract for potential wound healing applications. SN Appl. Sci. (2020); 2(881). https://doi.org/10.1007/s42452-020-2701-8
  • [12] Nelson JL, Mowad CM. Allergic contact dermatitis: patch testing beyond the TRUE Test. J Cli Aest Derm.(2010); 3(10): 36-41.
  • [13] Cohen DE. Contact dermatitis: a quarter century perspective. J Am Acad Dermatol. (2004); 51: 60-63. https://doi.org/10.1016/j.jaad.2003.01.002
  • [14] James WD, Rosenthal LE, Brancaccio RR, Marks JG. American academy of dermatology patch testing survey: use and effectiveness of this procedure. J Am Acad Dermatol. (1992); 26: 991-994. https://doi.org/10.1016/0190-9622(92)70145-6
  • [15] Warshaw EM, Nelson D. Prevalence of patch testing and methodology of dermatologists in the US: results of a cross-sectional survey. Am J Contact Dermatitis. (2002); 13: 53-58.
  • [16] Schleichert RA, Hostetler SG, Zirwas MJ. Patch testing practices of American Contact Dermatitis Society members. Dermatitis. (2010); 21: 98-101.
  • [17] Belsito DV. Patch testing with a standard allergen ("screening") tray: rewards and risks. Dermatol Therapy. (2004); 17: 231-239. https://doi.org/10.1111/j.1396-0296.2004.04033.x
  • [18] Katz BE, Fisher AA. Bacitracin: a unique topical antibiotic sensitizer. J Am Acad Dermatol. (1987); 17: 1016-1024. https://doi.org/10.1016/s0190-9622(87)70292-8
  • [19] Rietschel RL, Fowler JF. Fisher's Contact Dermatitis. 5th ed. Philadelphia: Lippincott Williams & Wilkins; (2001).
  • [20] Zwiefelhofer 2020 Geocode, Retrieved August 21 2020 from https://www.findlatitudeandlongitude.com/l/ LUTH+IDI+ARABA+IDI+ARABA%2C+SURULERE%2Clagos% 2C/973854/
  • [21] Zlotogorski A. Distribution of skin surface pH on the forehead and cheek of adults. Arch Dermatol Res. (1987); 279: 398-401. https://doi.org/10.1007/bf00412626
  • [22] Behne MJ, Meyer JW, Hanson KM, Barry NP, Murata S, Crumrine D, Clegg RW, Gratton E, Holleran WM, Elias PM, Mauro TM. NHE1 regulates the stratum corneum permeability barrier homeostasis: microenvironment acidification assessed with fluorescence lifetime imaging. J Biol Chem. (2002); 277: 47399-47406. https://doi.org/10.1074/jbc.M20475920
  • [23] Stewart ME, Downing DT, Cook JS, Hansen, JR, Strauss JS: Sebaceous gland activity and serum dehydroepiandrosterone sulfate levels in boys and girls. Arch Dermatol. (1992); 128: 1345-1348. https://doi.org/10.1001/archderm.1992.01680200055006
  • [24] Diridollou S, de Rigal J, Querleux B, Leroy F, Holloway Barbosa V: Comparative study of the hydration of the stratum corneum between four ethnic groups: influence of age. Int J Dermatol. (2007); 46(1): 11 -14. https://doi.org/10.1111/j.1365-4632.2007.03455.x
  • [25] Man MQ, Xin SJ, Song SP, Cho SY, Zhang X.J, Tu CX, Feingold KR, Elias P.M. Variation of skin surface pH, sebum content and stratum corneum hydration with age and gender in a large Chinese population. Skin pharmacol physiol. (2009); 22(4), 190-199. https://doi.org/10.1159/000231524
  • [26] Ilomuanya MO, Okubanjo OO, Azubuike CP, Oguntibeju A. Evaluation of the frequency of use of herbal drugs with concomitant administration of highly active antiretroviral therapy and its effect on medication adherence in two health care facilities in south western Nigeria. J AIDS and HIV Res. (2017); 9(1), 8-16. http://doi.org/10.5897/JAHR2016.0399
  • [27] Ilomuanya MO, Amenaghawon NA, Odimegwu J, Okubanjo OO, Aghaizu C, Adeyinka O, Akhimien T, Ajayi T. Formulation and optimization of gentamicin hydrogel infused with Tetracarpidium conophorum extract via central composite design for topical delivery, Turk J Pharm Sci. (2018); 15: 3319-3327. https://doi.org/10.4274/tjps.33042

Safety evaluation of different variants of a topically applied toilet bar soap range using skin irritancy testing methods in the Nigerian population

Year 2020, Volume 1, Issue 2, 40 - 45, 01.08.2020
https://doi.org/10.37662/jpt.2020.5

Abstract

Exposure to soaps can also alter the physiological properties of the skin such as pH, trans-epidermal water loss and sebum levels which are all determinants of skin irritability. Purpose: We aimed to evaluate the safety of different variants of a topically applied toilet soap range using skin irritancy testing methods in the Nigerian population. Five variants of commercially available soap bars were used in this study. Each subject was patch tested using standard methodology for application of patch test, with 5 variants of the proposed products. The pH, trans epidermal water loss (TEWL) and serum levels of the skin were determined before and after wash test. Diffuse plaster erythema was observed in 15.4% participants with 18.5% complaining of itching on the plaster site. All five variants were negative for allergic contact dermatitis after 48 hours and 96 hours post patch test. The soap range ensured that post washing pH of skin was maintained at 6.41 ±0.07 for all participants in the study. Post washing, the sebum concentration on the skin was significantly reduced by 95.01% ± 0.07 (p = 0.018). The different variants of the topically applied soap bar were non – irritant, compatible with human skin and showed no sign of allergic contact dermatitis.

References

  • [1] Lee HY, Stieger M, Yawalker N, Kakeda M. Cytokines and chemokines in irritant contact dermatitis. Mediators Inflamm. (2013); 916497. https://doi.org/10.1155/2013/916497
  • [2] Ayanlowo O, Olumide Y. Routine patch testing in a dermatology clinic of a teaching hospital in Nigeria. Nig Q J Hosp Med. (2007); 17 (4): 160-164. https://doi.org/10.4314/nqjhm.v17i4.12699
  • [3] Draelos ZD. The science behind skin care: Cleansers. J Cosmet Dermatol. (2018); 17(1): 8-14. https://doi.org/14.10.1111/jocd.12469
  • [4] Schmid-Wendtner MH, Korting HC. The pH of the ski surface and its impact on the barrier function. Skin Pharmacol Physiol. (2006); 19 (6): 296-302. https://doi.org/10.1159/00009467
  • [5] Korting HC, Kober M, Mueller M, Braun-Falco O. Influence of repeated washings with soap and synthetic detergents on pH and resident flora of the skin of forehead and forearm. Results of a cross- over trial in health probationers. Acta Derm Venereol. (1987); 67: 41- 47.
  • [6] Mukhopadhyay P. Cleansers and their role in various dermatological disorders. Indian J Dermatol. (2011); 56: 2-6. https://doi.org/10.4103/0019-5154.77542
  • [7] Tyebkhan G. A study on the pH of commonly used soaps/cleansers available in the Indian market. Indian J Dermatol Venereol Leprol. (2001); 67: 290-291.
  • [8] Fiszenson-Albala F, Auzerie V, Mahe E, Farinotti R, Durand-Stocco C, Crickx B, Descamps V. A 6-month prospective survey of cutaneous drug reactions in a hospital setting. British J Derm. (2003); 149(5): 1018-1022. https://doi.org/10.1111/j.1365-2133.2003.05584.x
  • [9] Breneman DL, Hanifin J, Berge CA, Keswick BH, Neumann PB. The effect of antibacterial soap with 1.5% triclocarban on Staphylococcus aureus in patients with atopic dermatitis. Cutis. (2000); 66(4): 296- 300.
  • [10] Mark BJ, Slavin RG. Allergic contact dermatitis. Med Clin N Am. (2006); 90: 169-185. https://doi.org/10.1016/j.mcna.2005.08.008
  • [11] Ilomuanya MO, Adebona AC, Wang W, Sowemimo A, Eziegbo CL, Silva BO, Adeosun SO, Joubert E, De Beer D. Development and characterization of collagen-based electrospun scaffolds containing silver sulphadiazine and Aspalathus linearis extract for potential wound healing applications. SN Appl. Sci. (2020); 2(881). https://doi.org/10.1007/s42452-020-2701-8
  • [12] Nelson JL, Mowad CM. Allergic contact dermatitis: patch testing beyond the TRUE Test. J Cli Aest Derm.(2010); 3(10): 36-41.
  • [13] Cohen DE. Contact dermatitis: a quarter century perspective. J Am Acad Dermatol. (2004); 51: 60-63. https://doi.org/10.1016/j.jaad.2003.01.002
  • [14] James WD, Rosenthal LE, Brancaccio RR, Marks JG. American academy of dermatology patch testing survey: use and effectiveness of this procedure. J Am Acad Dermatol. (1992); 26: 991-994. https://doi.org/10.1016/0190-9622(92)70145-6
  • [15] Warshaw EM, Nelson D. Prevalence of patch testing and methodology of dermatologists in the US: results of a cross-sectional survey. Am J Contact Dermatitis. (2002); 13: 53-58.
  • [16] Schleichert RA, Hostetler SG, Zirwas MJ. Patch testing practices of American Contact Dermatitis Society members. Dermatitis. (2010); 21: 98-101.
  • [17] Belsito DV. Patch testing with a standard allergen ("screening") tray: rewards and risks. Dermatol Therapy. (2004); 17: 231-239. https://doi.org/10.1111/j.1396-0296.2004.04033.x
  • [18] Katz BE, Fisher AA. Bacitracin: a unique topical antibiotic sensitizer. J Am Acad Dermatol. (1987); 17: 1016-1024. https://doi.org/10.1016/s0190-9622(87)70292-8
  • [19] Rietschel RL, Fowler JF. Fisher's Contact Dermatitis. 5th ed. Philadelphia: Lippincott Williams & Wilkins; (2001).
  • [20] Zwiefelhofer 2020 Geocode, Retrieved August 21 2020 from https://www.findlatitudeandlongitude.com/l/ LUTH+IDI+ARABA+IDI+ARABA%2C+SURULERE%2Clagos% 2C/973854/
  • [21] Zlotogorski A. Distribution of skin surface pH on the forehead and cheek of adults. Arch Dermatol Res. (1987); 279: 398-401. https://doi.org/10.1007/bf00412626
  • [22] Behne MJ, Meyer JW, Hanson KM, Barry NP, Murata S, Crumrine D, Clegg RW, Gratton E, Holleran WM, Elias PM, Mauro TM. NHE1 regulates the stratum corneum permeability barrier homeostasis: microenvironment acidification assessed with fluorescence lifetime imaging. J Biol Chem. (2002); 277: 47399-47406. https://doi.org/10.1074/jbc.M20475920
  • [23] Stewart ME, Downing DT, Cook JS, Hansen, JR, Strauss JS: Sebaceous gland activity and serum dehydroepiandrosterone sulfate levels in boys and girls. Arch Dermatol. (1992); 128: 1345-1348. https://doi.org/10.1001/archderm.1992.01680200055006
  • [24] Diridollou S, de Rigal J, Querleux B, Leroy F, Holloway Barbosa V: Comparative study of the hydration of the stratum corneum between four ethnic groups: influence of age. Int J Dermatol. (2007); 46(1): 11 -14. https://doi.org/10.1111/j.1365-4632.2007.03455.x
  • [25] Man MQ, Xin SJ, Song SP, Cho SY, Zhang X.J, Tu CX, Feingold KR, Elias P.M. Variation of skin surface pH, sebum content and stratum corneum hydration with age and gender in a large Chinese population. Skin pharmacol physiol. (2009); 22(4), 190-199. https://doi.org/10.1159/000231524
  • [26] Ilomuanya MO, Okubanjo OO, Azubuike CP, Oguntibeju A. Evaluation of the frequency of use of herbal drugs with concomitant administration of highly active antiretroviral therapy and its effect on medication adherence in two health care facilities in south western Nigeria. J AIDS and HIV Res. (2017); 9(1), 8-16. http://doi.org/10.5897/JAHR2016.0399
  • [27] Ilomuanya MO, Amenaghawon NA, Odimegwu J, Okubanjo OO, Aghaizu C, Adeyinka O, Akhimien T, Ajayi T. Formulation and optimization of gentamicin hydrogel infused with Tetracarpidium conophorum extract via central composite design for topical delivery, Turk J Pharm Sci. (2018); 15: 3319-3327. https://doi.org/10.4274/tjps.33042

Details

Primary Language English
Subjects Pharmacology and Pharmacy
Journal Section Research Articles
Authors

Margaret ILOMUANYA> (Primary Author)
University of Lagos
0000-0001-8819-1937
Nigeria


Olusola AYANLOWO This is me
University of Lagos
0000-0002-1134-3813
Nigeria


Uloma UBANİ-UKOMA This is me
University of Lagos
0000-0003-2569-1875
Nigeria


Modupe OLOGUNAGBA This is me
Univeristy of Lagos
0000-0000-0000-0000
Türkiye


Richard ODAFİ This is me
PZ Cussons
0000-0000-0000-0000
Nigeria


Uchenna NWANKANMA This is me
PZ Cussons
0000-0000-0000-0000
Nigeria

Supporting Institution University of Lagos, Faculty of Pharmacy, Department of Pharmaceutics and Pharmaceutical Technology, Lagos, Nigeria
Publication Date August 1, 2020
Submission Date July 20, 2020
Acceptance Date August 26, 2020
Published in Issue Year 2020, Volume 1, Issue 2

Cite

Bibtex @research article { jpharmtech772140, journal = {Journal of Pharmaceutical Technology}, eissn = {2717-7904}, address = {Anadolu Üniversitesi Eczacılık Fakültesi Farmasötik Teknoloji Abd Tepebaşı Eskişehir}, publisher = {Mustafa Sinan KAYNAK}, year = {2020}, volume = {1}, number = {2}, pages = {40 - 45}, doi = {10.37662/jpt.2020.5}, title = {Safety evaluation of different variants of a topically applied toilet bar soap range using skin irritancy testing methods in the Nigerian population}, key = {cite}, author = {Ilomuanya, Margaret and Ayanlowo, Olusola and Ubani-ukoma, Uloma and Ologunagba, Modupe and Odafi, Richard and Nwankanma, Uchenna} }
APA Ilomuanya, M. , Ayanlowo, O. , Ubani-ukoma, U. , Ologunagba, M. , Odafi, R. & Nwankanma, U. (2020). Safety evaluation of different variants of a topically applied toilet bar soap range using skin irritancy testing methods in the Nigerian population . Journal of Pharmaceutical Technology , 1 (2) , 40-45 . DOI: 10.37662/jpt.2020.5
MLA Ilomuanya, M. , Ayanlowo, O. , Ubani-ukoma, U. , Ologunagba, M. , Odafi, R. , Nwankanma, U. "Safety evaluation of different variants of a topically applied toilet bar soap range using skin irritancy testing methods in the Nigerian population" . Journal of Pharmaceutical Technology 1 (2020 ): 40-45 <https://dergipark.org.tr/en/pub/jpharmtech/issue/54948/772140>
Chicago Ilomuanya, M. , Ayanlowo, O. , Ubani-ukoma, U. , Ologunagba, M. , Odafi, R. , Nwankanma, U. "Safety evaluation of different variants of a topically applied toilet bar soap range using skin irritancy testing methods in the Nigerian population". Journal of Pharmaceutical Technology 1 (2020 ): 40-45
RIS TY - JOUR T1 - Safety evaluation of different variants of a topically applied toilet bar soap range using skin irritancy testing methods in the Nigerian population AU - MargaretIlomuanya, OlusolaAyanlowo, UlomaUbani-ukoma, ModupeOlogunagba, RichardOdafi, UchennaNwankanma Y1 - 2020 PY - 2020 N1 - doi: 10.37662/jpt.2020.5 DO - 10.37662/jpt.2020.5 T2 - Journal of Pharmaceutical Technology JF - Journal JO - JOR SP - 40 EP - 45 VL - 1 IS - 2 SN - -2717-7904 M3 - doi: 10.37662/jpt.2020.5 UR - https://doi.org/10.37662/jpt.2020.5 Y2 - 2020 ER -
EndNote %0 Journal of Pharmaceutical Technology Safety evaluation of different variants of a topically applied toilet bar soap range using skin irritancy testing methods in the Nigerian population %A Margaret Ilomuanya , Olusola Ayanlowo , Uloma Ubani-ukoma , Modupe Ologunagba , Richard Odafi , Uchenna Nwankanma %T Safety evaluation of different variants of a topically applied toilet bar soap range using skin irritancy testing methods in the Nigerian population %D 2020 %J Journal of Pharmaceutical Technology %P -2717-7904 %V 1 %N 2 %R doi: 10.37662/jpt.2020.5 %U 10.37662/jpt.2020.5
ISNAD Ilomuanya, Margaret , Ayanlowo, Olusola , Ubani-ukoma, Uloma , Ologunagba, Modupe , Odafi, Richard , Nwankanma, Uchenna . "Safety evaluation of different variants of a topically applied toilet bar soap range using skin irritancy testing methods in the Nigerian population". Journal of Pharmaceutical Technology 1 / 2 (August 2020): 40-45 . https://doi.org/10.37662/jpt.2020.5
AMA Ilomuanya M. , Ayanlowo O. , Ubani-ukoma U. , Ologunagba M. , Odafi R. , Nwankanma U. Safety evaluation of different variants of a topically applied toilet bar soap range using skin irritancy testing methods in the Nigerian population. J Pharm Technol. 2020; 1(2): 40-45.
Vancouver Ilomuanya M. , Ayanlowo O. , Ubani-ukoma U. , Ologunagba M. , Odafi R. , Nwankanma U. Safety evaluation of different variants of a topically applied toilet bar soap range using skin irritancy testing methods in the Nigerian population. Journal of Pharmaceutical Technology. 2020; 1(2): 40-45.
IEEE M. Ilomuanya , O. Ayanlowo , U. Ubani-ukoma , M. Ologunagba , R. Odafi and U. Nwankanma , "Safety evaluation of different variants of a topically applied toilet bar soap range using skin irritancy testing methods in the Nigerian population", Journal of Pharmaceutical Technology, vol. 1, no. 2, pp. 40-45, Aug. 2020, doi:10.37662/jpt.2020.5

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