j. res. pharm. Journal of Research in Pharmacy 2630-6344 Marmara University 10.12991/jrespharm.1643734 Pharmaceutical Delivery Technologies İlaç Dağıtım Teknolojileri Phytosome based cosmeceuticals for enhancing percutaneous absorption and delivery Dwivedi Jyotsana PSIT- Pranveer Singh Institute of Technology (Pharmacy) Kanpur-209305 Wal Pranay PSIT- Pranveer Singh Institute of Technology (Pharmacy) Kanpur-209305 Kaushal Shubhi PSIT- Pranveer Singh Institute of Technology (Pharmacy) Kanpur-209305 Tripathi Arpan Kumar KIPS, Shri Shankaracharya Professional University Gupta Priyanka Shivalik College of Engineering, Shimla Bypass Road Shiniwala, Dehradun Prakash Rao Surada Columbia Institute of Pharmacy, Raipur 03 03 2025 29 1 242 271 10 26 2023 04 23 2024 Copyright © 2010, Journal of Research in Pharmacy 2010 Journal of Research in Pharmacy

The therapeutic efficacy of various phytoconstituents is improved by the use of phytosome, innovative drug delivery methods based on phytochemicals, by enhancing their absorption, bioavailability, and therapeutic availability. This exceedingly complex type of herbal formulation contains the active phytoconstituent of the herbal extract and is joined by a phospholipid molecule. They also operate as vesicular systems for a wide range of fascinating and important phytoactives. The phytosome method produces startlingly tiny spheres or cells, which is advantageous in keeping active phytochemical contents from being destroyed by the stomach environment. Phytosome also produce pharmacokinetic and pharmacodynamic effects that are more potent than those of conventional herbal extracts. Phytosome demonstrated increased pharmacokinetics and pharmacodynamic response when compared to conventional botanical extracts. Through the use of phytosome technology, the bioavailability of several of the most widely used herbal extracts, such as milk thistle, Ginkgo biloba, grape seed, green tea, hawthorn, ginseng, etc., has been improved. These drug-phospholipid complexes can be produced as a liquid solution, suspension, emulsion, syrup, lotion, gel, cream, tablet, capsule, powder, or granule. The purpose of this review is to emphasize the application of how the phytosome technology has helped to improve the bioavailability and absorbance of the cosmeceuticals.

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