j. res. pharm. Journal of Research in Pharmacy 2630-6344 Marmara University 10.12991/jrespharm.1644566 Pharmacology and Pharmaceutical Sciences (Other) Eczacılık ve İlaç Bilimleri (Diğer) Proof-of-concept about the role of dietary agents in the inhibition and prevention of carcinogenesis and metastasis: Focus on animal model studies Sabitaliyevich Uteuliyev Yerzhan Scientific Center for Innovative Technologies and Research Aizat Moldagassimova Scientific Center for Innovative Technologies and Research Zhanar Ospanova Department of Healthcare of Zhambyl region in Kazakhstan Romero Mirna Azalea Facultad de Medicina, Universidad Autónoma de Guerrero, Laboratorio de Investigación Clínica 03 03 2025 29 1 436 444 09 10 2024 12 17 2024 Copyright © 2010, Journal of Research in Pharmacy 2010 Journal of Research in Pharmacy

The field of nutrigenomics has gained considerable limelight and interdisciplinary researchers have started to realize its significance as a goldmine for the discovery of pathways that are important as dietary targets. Emerging evidence has provided wealth of exciting proof-of-concept studies highlighting an important role in the elucidation of oncogenic signaling cascades that can be pharmacologically targeted by dietary agents, whole extracts and isolated compounds for the inhibition/prevention of carcinogenesis and metastasis. In this review, we have critically analyzed some of the mechanistic animal models studies which have rationally propelled the field in a frontward direction. We also provide an overview of the fruits-mediated anti-metastatic effects in metastasis models that highlight how nutrigenomics may be combined with pharmacological therapies for synergistic effects, potentially ushering a path towards precision nutrition for cancer.

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