Voltammetric analysis and electrochemical behavior of an antibiotic drug Nifuroxazide on a boron-doped diamond electrode in the existence of a cationic surfactant

Year 2025, Volume: 29 Issue: 3, 985 - 995, 04.06.2025

Farman M. Hamarasool Dana M. H. Ameen Yavuz Yardım

https://doi.org/10.12991/jrespharm.1693831

Abstract

In this work, the voltammetric sensing of nifuroxazide (NFX) was assessed utilizing a boron-doped diamond (BDD) electrode that underwent electrochemical pretreatment, enhancing its surface activity. Cyclic voltammograms of NFX revealed well-defined, single, and irreversible peaks at 0.94 V (vs. Ag/AgCl) in a 0.04 M Britton- Robinson (BR) buffer solution at pH 6.0. The oxidation peaks of NFX were found to be pH-dependent across a range from 2.0 to 12.0. Introducing a cationc surfactant (CTAB; cetyltrimethylammonium bromide) into the selected electrolyte increased the anodic peak currents of NFX. Under optimized conditions, a linear relationship was established for NFX quantification in 0.04 M solution of BR buffer (pH 6.0) containing 2×10-4 M CTAB at +1.02 V (vs. Ag/AgCl). The linear range spanned from 0.05 to 2.0 μg mL-1 (1.8×10-7 – 7.2×10-6 M), with a detection limit of 0.013 μg mL-1 (4.7×10-8 M). The NFX concentration in the drug formulation was successfully quantized using this method.

Keywords

Nifuroxazide , voltammetry , cationic surfactant , boron-doped diamond electrode , drug form

References

• [1] Kurugöl Z, Devrim İ. Gastrointestinal infections. J Pediatr Inf. 2014; 8: 71-81. https://doi.org/10.5152/ced.2013.1509.
• [2] Nguyen TV, Van PL, Huy CL, Gia KN, Weintraub A. Etiology and epidemiology of diarrhea in children in Hanoi, Vietnam. Int J Infect Dis. 2006; 10: 298-308. https://doi.org/10.1016/j.ijid.2005.05.009.
• [3] Carlos CC, Saniel MC. Etiology and epidemiology of diarrhea. Phillips J Microbiol Infect Dis. 1990; 19: 51-53.
• [4] Black RE, Cousens S, Johnson HL, Lawn JE, Rudan I, Bassani DG, Jha P, Campbell H, Walker CF, Cibulskis R, Eisele T, Liu L, Mathers C. Global, regional, and national causes of child mortality in 2008: A systematic analysis. Lancet 2010; 375: 1969-1987. https://doi.org/10.1016/S0140-6736(10)60549-1.
• [5] Karlowicz-Bodalska K, Głowacka K, Boszkiewicz K, Han S, Wiela-Hojeńska A. Safety of oral nifuroxazide–analysis of data from a spontaneous reporting system. Acta Pol Pharm-Drug Res. 2019; :7 45-751. https://doi.org/10.32383/appdr/105805.
• [6] Begovic B, Ahmedtagic S, Calkic L, Vehabović M, Kovacevic SB, Catic T, Mehic M. Open clinical trial on using nifuroxazide compared to probiotics in treating acute diarrhoeas in adults. Mater Sociomed. 2016; 28: 454-458. https://doi.org/10.5455/msm.2016.28.454-458
• [7] Abdelwahab NS, Ali NW, Zaki MM, Abdelkawy M, El-Saadi MT. Quantitative determination of synthesized genotoxic ımpurities in nifuroxazide capsules by validated chromatographic methods. AOAC Inter. 2018; 101: 385-393. https://doi.org/10.5740/jaoacint.17-0015.
• [8] Xu Q, Yuan A, Zhang R, Bian X, Chen D, Hu X. Application of electrochemical methods for pharmaceutical and drug analysis. Curr. Pharm. Anal.2009; 5: 144-155. https://doi.org/10.2174/157341209788172889.
• [9] Karadurmus L, Sahin IF, Kurbanoglu S, Ozkan SA. Electrochemical determination of non-steroidal anti-inflammatory drugs. Curr Anal Chem. 2019; 15: 485-501. https://doi.org/10.2174/1573411014666180917113920.
• [10] Freitas JM, Oliveira TD, Munoz RA, Richter EM. Boron doped diamond electrodes in flow-based systems. Front Chem. 2019; 7: 190. https://doi.org/10.3389/fchem.2019.00190.
• [11] Cobb SJ, Ayres ZJ, Macpherson JV. Boron doped diamond: a designer electrode material for the twenty-first century. Annu Rev Anal Chem. 2018; 11: 463-484. https://doi.org/10.1146/annurev-anchem-061417-010107.
• [12] Kondo T. Recent electroanalytical applications of boron-doped diamond electrodes. Curr Opin Electrochem. 2022; 32: 100891. https://doi.org/10.1016/j.coelec.2021.100891.
• [13] Lourencao BC, Brocenschi RF, Medeiros RA, Fatibello-Filho O, Rocha- Filho RC. Analytical applications of electrochemically pretreated boron-doped diamond electrodes. ChemElectroChem 2020; 7: 1291-1311. https://doi.org/10.1002/celc.202000050.
• [14] Kıran M, Yardım Y. Voltammetric measurement of catechol-O-methyltransferase inhibitor tolcapone in the pharmaceutical form on the boron-doped diamond electrode. Turk J Chem. 2024; 48: 184-194. https://doi.org/10.55730/1300-0527.3650.
• [15] Ali HS, Yardım Y. Simultaneous estimation of total phenolic and alkaloid contents in the tea samples by utilizing the catechin and caffeine oxidation signals through the square-wave voltammetry technique. Food Chem. 2024; 441: 138262. https://doi.org/10.1016/j.foodchem.2023.138262.
• [16] Yıldız MB, Levent A. Highly sensitive and selective electrochemical monitoring of nickel in crude oil samples using cathodically pretreated-boron doped diamond electrode. Diam Rel Mater. 2024; 145: 111058. https://doi.org/10.1016/j.diamond.2024.111058.
• [17] Altunkaynak Y, Önal G, Levent A. Application of boron‑doped diamond electrode for rapid and sensitive voltammetric detection of vildagliptin in anionic surfactant medium. Monatsh Chem. 2023; 154: 181-190. https://doi.org/10.1007/s00706-022-03020-9
• [18] Uçar M, Levent A. Novel voltammetric strategy for determination and electrochemical evaluation of progesterone by CPT-BDD electrode. Diam Rel Mater. 2021; 117: 1 108459. https://doi.org/10.1016/j.diamond.2021.108459
• [19] Rosen MJ, Kunjappu JT. Surfactants and interfacial phenomena. John Wiley & Sons; 2012. https://doi.org/10.1002/9781118228920.
• [20] Jin Y, Liu F, Tong M, Hou Y. Removal of arsenate by cetyltrimethylammonium bromide modified magnetic nanoparticles. J Hazard Mater. 2012; 227-228: 461-468. https://doi.org/10.1016/j.jhazmat.2012.05.004.
• [21] Leng Y, Qian S, Wang Y, Lu C, Ji X, Lu Z, Lin H. Single-indicator-based multidimensional sensing: Detection and identification of heavy metal ions and understanding the foundations from experiment to simulation. Sci Rep. 2016; 6: 25354. https://doi.org/10.1038/srep25354.
• [22] Önal G, Altunkaynak Y, Levent A. Application of BiFE for electrochemical properties and determination of loratadine by cathodic stripping voltammetry in the cationic surfactant medium. J Iran Chem Soc. 2021; 18: 3465-3475. https://doi.org/10.1007/s13738-021-02286-w.
• [23] Radi A, El-Laban S, Kenawy IM. Determination of nifuroxazide in capsules by differential pulse polarography. Anal Sci. 1998; 14: 607-608. https://doi.org/10.2116/analsci.14.607.
• [24] Buchberger W, Niessner G, Bakry R. Determination of nifuroxazide with polarography and adsorptive stripping voltammetry at mercury and carbon paste electrodes. Fresenius J Anal Chem. 1998; 362: 205-208. https://doi.org/10.1007/s002160051060.
• [25] Radi A, El Ries MA. Determination of nifuroxazide in human serum by adsorptive stripping voltammetry. Anal Sci. 1999; 15: 385-388. https://doi.org/10.2116/analsci.15.385.
• [26] Radi A. Voltammetric study of nifuroxazide at unmodified and Sephadex-modified carbon paste electrodes. Fresenius J Anal Chem. 1999; 364: 590-594. https://doi.org/10.1007/s002160051391.
• [27] Mozo JD, Carbajo J, Sturm JC, Núñez‐Vergara LJ, Salgado P, Squella JA. Determination of nifuroxazide by flow injection linear adsorptive stripping voltammetry on a screen‐printed carbon nanofiber modified electrode. Electroanalysis. 2012; 24: 676-682. https://doi.org/10.1002/elan.201100612.
• [28] Toral MI, Paine M, Leyton P, Richter P. Determination of attapulgite and nifuroxazide in pharmaceutical formulations by sequential digital derivative spectrophotometry. J OAOC Int. 2004; 87: 1323-1328.
• [29] Guinebault PR, Broquaire M, Braithwaite RA. Determination of nifuroxazide in biological fluids by automated high-performance liquid chromatography with large-volume injection. J Chromatogr. 1981; 204: 329-333. https://doi.org/10.1016/s0021-9673(00)81675-1.
• [30] Barzani HAH, Hoshyar SA, Özok Hİ, Yardım Y. Developing an electroanalytical procedure for the determination of caffeic acid phenethyl ester at a boron-doped diamond electrode by the use of cationic surfactant media. Diam Rel Mater. 2022; 124: 108934. https://doi.org/10.1016/j.diamond.2022.108934.
• [31] Barzani HAH, Hoshyar SA, Yunusoğlu O, Yardım Y. Sensing ivacaftor accomplished using the square-wave voltammetric technique with the assistance of a cationic surfactant on a boron-doped diamond electrode. Diam Rel Mater. 2024; 144: 110932. https://doi.org/10.1016/j.diamond.2024.110932.
• [32] Abdullah AA, Yardım Y, Şentürk Z. The performance of cathodically pretreated boron-doped diamond electrode in cationic surfactant media for enhancing the adsorptive stripping voltammetric determination of catechol-containing flavonoid quercetin in apple juice. Talanta 2018; 187:1 56-164. https://doi.org/10.1016/j.talanta.2018.05.016.