Akut Migren Tedavisinde Propofol ve Klorpromazin: Prospektif Randomize Bir Çalışmadan Elde Edilen Bulgular

Year 2024, Volume: 3 Issue: 3, 56 - 64, 28.12.2024

Sarper Sağlam , Özlem Güneysel

https://doi.org/10.61745/jsmsau.1584825

Abstract

Amaç: Bu çalışma, akut migren ataklarının yönetiminde propofol ve klorpromazinin etkinliğini karşılaştırmayı ve acil serviste (AS) migren tedavisinin optimize edilmesine katkıda bulunmayı amaçlamıştır.
Yöntemler: Bu prospektif, randomize gözlemsel çalışmada, yaşları 18-65 arasında değişen 180 migren hastası iki gruba randomize edildi. Bir gruba her 10 dakikada bir 10 mg (maksimum 50 mg’a kadar) propofol, diğer gruba ise her 20 dakikada bir 12.5 mg (maksimum 37.5 mg’a kadar) klorpromazin uygulandı. Ağrı, görsel analog skala (VAS) kullanılarak her 10 dakikada bir değerlendirildi.
Bulgular: Başlangıçtaki ortalama VAS skorları propofol grubunda 8,24 ± 1,72, klorpromazin grubunda ise 8,83 ± 1,43 idi. Propofol grubunda VAS skorları 10., 20. ve 30. dakikalarda sırasıyla 5,19 ± 2,79, 2,66 ± 2,91 ve 1,25 ± 2,14 birim azaldı. Klorpromazin grubunda bu azalmalar sırasıyla 4,82 ± 2,99, 2,50 ± 2,93 ve 1,03 ± 2,20 birim olarak ölçüldü. 60. dakikada toplam VAS azalması propofol grubunda 25,00 ± 12,25, klorpromazin grubunda ise 23,10 ± 11,40 olarak belirlendi ve gruplar arasında istatistiksel olarak anlamlı bir fark saptanmadı.
Sonuç: Propofol, AS’de akut migren yönetiminde klorpromazin kadar etkiliydi ve benzer bir etki başlama süresi ile daha iyi bir yan etki profili gösterdi.

Keywords

migren atağı, propofol, klorpromazin, akut migren tedavisi

Propofol vs. Chlorpromazine for Acute Migraine Treatment: Insights from a Prospective Randomized Trial

Abstract

Objective: This study aimed to compare the efficacy of propofol and chlorpromazine in managing acute migraine attacks and to contribute to optimizing the treatment of patients with migraine in the ED.
Methods: This prospective, randomized observational study included 180 migraine patients aged 18–65 presenting to the ED. Patients were randomized into two groups: one received propofol (10 mg every 10 minutes, up to 50 mg), and the other received chlorpromazine (12.5 mg every 20 minutes, up to 37.5 mg). Pain was monitored every 10 minutes using a visual analog scale (VAS).
Results: At admission, the mean VAS score was 8.24 ± 1.72 in the propofol group and 8.83 ± 1.43 in the chlorpromazine group. In the propofol group, the VAS score decreased by 5.19 ± 2.79, 2.66 ± 2.91, and 1.25 ± 2.14 units at the 10th, 20th, and 30th minutes, respectively. In the chlorpromazine group, the VAS score decreased by 4.82 ± 2.99, 2.50 ± 2.93, and 1.03 ± 2.20 units at the 10th, 20th, and 30th minutes, respectively. By the 60th minute, the total VAS reduction was 25.00 ± 12.25 in the propofol group and 23.10 ± 11.40 in the chlorpromazine group. Although pain reduction initially occurred more rapidly in the chlorpromazine group, there was no statistically significant difference between the groups at the 60-minute mark.
Conclusion: Propofol was as effective as chlorpromazine for treating migraines in the ED, with a comparable onset of action and a better side-effect profile.

Keywords

migraine attack, propofol, chlorpromazine, acute migraine attack

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