EFFECT OF FTO rs9939609 POLIMORPHISM ON OBESITY IN TURKISH POPULATION

Year 2020, Volume: 4 Issue: 4, 255 - 262, 07.11.2020

Meliha Merve Hız Çiçekliyurt Sevilay Oğuz Kılıç Levent Elmas

https://doi.org/10.26900/jsp.4.022

Abstract

Obesity is a disease that is affected by environmental conditions as well as genetic predisposition. This is a case-control study that aimed to investigate the relationship between FTO rs9939609 polymorphism and obesity. The relation between the rs9939609 polymorphism and obesity in 80 ower-weight (BMI 30) and 131 under/normal weight (BMI 30) subjects was examined. The allele and genotype frequencies of each group were determined by the allele counting method. The relationship between single nucleotide exchange and obesity risk was calculated using the odds ratio. Statistical analyzes were performed with SPSS 18.0.
Results: The frequency of T allele was 0.58 and 0.45 respectively in the healthy and overweight group when allele frequencies of both groups were compared. The change in allele frequency increased the obesity rate by 1.8 fold. The rs99399609 polymorphism increases obesity risk by2.7 fold in the homozygotes model.
Conclusions: In this research, we found statistically significant results in allele frequency difference and allele positivity. The relationship between rs9939609 polymorphism and obesity will be highlighted by larger population studies.

Keywords

Adiposity, FTO, rs9939609, BMI, Body composition

References

• AĞAGÜNDÜZ, D., GEZMEN-KARADAĞ, M. 2019, Association of FTO common variant (rs9939609) with body fat in Turkish individuals, Lipids in health and disease, 18 (1), 212.
• AL-SERRI, A., AL-BUSTAN, S.A., KAMKAR, M., THOMAS, D., ALSMADI, O., AL-TEMAIMI, R., MOJIMINIYI, O.A., ABDELLA, N.A., 2018, Association of FTO rs9939609 with Obesity in the Kuwaiti Population: A Public Health Concern? Med Princ Pract, 27 (2), 145-151.
• CLAUSNITZER, M, DANKEL, S.N., KIM, K.H., QUON, G., MEULEMAN, W., HAUGEN, C., GLUNK, V., SOUSA, I.S., BEAUDRY, J.L., PUVIINDRAN, V., ABDENNUR, N.A., LIU, J., SVENSSON, P.A., HSU, Y.H., DRUCKER, D.J., MELLGREN, G., HUI, C.C., HAUNER, H., KELLIS, M., 2015, FTO Obesity Variant Circuitry and Adipocyte Browning in Humans, N Engl J Med, 373, 895-907.
• DOAEI S., KALANTARI N., MOHAMMADI N.K., TABESH G.A., GHOLAMALIZADEH M, 2017, Macronutrients and the FTO gene expression in hypothalamus, Mar-Apr, a systematic review of experimental studies, Indian Heart J, 69 (2), 277-281.
• FAWCETT, K.A., BARROSO, I, 2010, The genetics of obesity: FTO leads the way, Trends in Genetics 26, 266–274.
• FINKELSTEIN E.A., TROGDON J.G., COHEN J.W, 2009, Annual medical spending attributable to obesity: payer- and service-specific estimates, Health Aff, 28(5): w822–w831.
• GUIFANG, J, YANG, C.G., YANG, S., JIAN, S., JIAN, X., YI, C., ZHOU, Z., HE, C., 2008, Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO, FEBS Letters, 582, 3313–3319.
• GONZÁLEZ-SÁNCHEZ, J. L., ZABENA, C., MARTÍNEZ-LARRAD, M. T., MARTÍNEZ-CALATRAVA, M. J., PÉREZ-BARBA, M., SERRANO-RÍOS, M., 2009, Variant rs9939609 in the FTO gene is associated with obesity in an adult population from Spain, Clinical endocrinology, 70 (3), 390–393.
• FRAYLING, T. M., TIMPSON, N. J., WEEDON, M. N., ZEGGINI, E., FREATHY, R. M., LINDGREN, C. M., PERRY, J. R., ELLIOTT, K. S., LANGO, H., RAYNER, N. W., SHIELDS, B., HARRIES, L. W., BARRETT, J. C., ELLARD, S., GROVES, C. J., KNIGHT, B., PATCH, A. M., NESS, A. R., EBRAHIM, S., LAWLOR, D. A., MCCARTHY, M.I, 2007, A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 316 (5826), 889–894.
• HSIAO T.J., LIN E, 2016, Association of a common rs9939609 variant in the fat mass and obesity-associated (FTO) gene with obesity and metabolic phenotypes in a Taiwanese population: a replication study. J Genet, 95 (3), 595-601.
• HU F.B, 2003, Sedentary lifestyle and risk of obesity and type 2 diabetes, Lipids, 38 (2), 103-8.
• HUNT, S.C., STONE, S., XIN, Y., SCHERER, C.A., MAGNESS, C.L., IADONATO, S.P., HOPKINS, P.N., ADAMS, T.D., 2008, Association of the FTO gene with BMI. Obesity, 16(4), 902-904.
• LIU, G., ZHU, H., LAGOU, V., GUTIN, B., STALLMANN-JORGENSEN, I. S., TREIBER, F. A., DONG, Y., SNIEDER, H., 2010, FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth, BMC Medical Genetics, 11, 57.
• MERRA, G., GUALTIERI, P., CIOCCOLONI, G., FALCO, S., BIGIONI, G., TARSITANO, M. G., CAPACCI, A., PICCIONI, A., COSTACURTA, M., FRANCESCHI, F., & DI RENZO, L., 2020, FTO rs9939609 influence on adipose tissue localization in the Italian population. European review for medical and pharmacological sciences, 24 (6), 3223–3235.
• QI, Q., KILPELÄINEN, T. O., DOWNER, M. K., TANAKA, T., SMITH, C. E., SLUIJS, I., SONESTEDT, E., CHU, A. Y., RENSTRÖM, F., LIN, X., ÄNGQUIST, L. H., HUANG, J., LIU, Z., LI, Y., ASIF ALI, M., XU, M., AHLUWALIA, T. S., BOER, J. M., CHEN, P., DAIMON, M., … QI, L., 2014, FTO genetic variants, dietary intake and body mass index: insights from 177,330 individuals. Human molecular genetics, 23 (25), 6961–6972.
• RIZZI, M., MAZZUOLI, S., REGANO, N., INGUAGGIATO, R., BIANCO, M., LEANDRO, G., BUGIANESI, E., NOÈ, D., ORZES, N., PALLINI, P., PETRONI, M.L., TESTINO, G., GUGLIELMI, F.W., 2016, Undernutrition, risk of malnutritidy. World J Gastrointest Oncol, 8 (7), 563-572.
• SPEAKMAN, JR., 2015, The ‘Fat Mass and Obesity Related’ (FTO) gene: Mechanisms of Impact on Obesity and Energy Balance, Curr Obes Rep, 4: 73–91.
• SOLAK, M., OZDEMIR ERDOGAN, M., YILDIZ, S. H., UCOK, K., YUKSEL, S., ARIKAN TERZI, E. S., & BESTEPE, A. 2014, Association of obesity with rs1421085 and rs9939609 polymorphisms of FTO gene, Mol Biol Rep, 41 (11), 7381-6.
• SONG, Y., YOU, N. C., HSU, Y. H., HOWARD, B. V., LANGER, R. D., MANSON, J. E., NATHAN, L., NIU, T., F TINKER, L., LIU S., 2008, FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal women. Obesity (Silver Spring), 16 (11), 2472-80.
• TANOFSKY-KRAFF, M., HAN, J.C., ANANDALINGAM, K., SHOMAKER, L.B., COLUMBO, K.M., WOLKOFF, L.E., KOZLOSKY, M., ELLIOTT, C., RANZENHOFER, L.M., ROZA, C.A., YANOVSKI, S.Z., YANOVSKI, J.A., 2009, The FTO gene rs9939609 obesity-risk allele and loss of control over eating, Am J Clin Nutr, ;90 (6), 1483-8.
• WARDLE, J., CARNELL, S., HAWORTH, C.M., FAROOQI, I.S., O'RAHILLY, S., PLOMIN, R., 2008, Obesity associated genetic variation in FTO is associated with diminished satiety. J Clin Endocrinol Metab. 2008, 93 (9): 3640-3643.
• WOOD, A.R., TYRRELL, J., BEAUMONT, R., JONES, S. E., TUKE, M. A., RUTH, K. S., GIANT CONSORTIUM, YAGHOOTKAR, H., FREATHY, R. M., MURRAY, A., FRAYLING, T. M., & WEEDON, M. N., 2016, Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. Diabetologia, 59: 1214-1221.
• YANG, J., LOOS, R. J., POWELL, J. E., MEDLAND, S. E., SPELIOTES, E. K., CHASMAN, D. I., ROSE, L. M., THORLEIFSSON, G., STEINTHORSDOTTIR, V., MÄGI, R., WAITE, L., SMITH, A. V., YERGES-ARMSTRONG, L. M., MONDA, K. L., HADLEY, D., MAHAJAN, A., LI, G., KAPUR, K., VITART, V., HUFFMAN, J. E., … VISSCHER, P.M., 2012, FTO genotype is associated with phenotypic variability of body mass index. Nature, 490, 267-272.
• YANG, Y., LIU, B., XIA, W., YAN, J., LIU, H.Y., HU, L., LIU, S.M., 2017, FTO Genotype and Type 2 Diabetes Mellitus: Spatial Analysis and Meta-Analysis of 62 Case-Control Studies from Different Regions, Genes, 8, 70.
• YEO, G.S.H., 2011, FTO and Obesity: A Problem for a Billion People, Journal of Neuroendocrinology, 24, 393–394,