Investigation of the antimicrobial effects of niclosamide, furosemide and nifedipine drugs released from a modified hydrogel structure

Year 2025, Issue: 062, 1 - 11, 30.09.2025

Mukaddes Keskinates , Bahar Yılmaz , Mevlüt Bayrakcı

https://doi.org/10.59313/jsr-a.1620817

Abstract

HEMA-based hydrogels were also developed and they were characterized for a few drugs including nifedipine, furosemide and niclosamide. The HEMA hydrogels were synthesized by functionalizing with methacrylated β−cyclodextrin monomer and then were tested in drug release studies. Antimicrobial study against bacteria: The pathogen was studied using disc diffusion and microdilution methods for the drug released from HEMA-based hydrogels. The hydrogel synthesized was found to have a very high capacity for absorption of water and it was also found that depending on this, the potential of drug absorption was also very high. In vitro, cumulative drug release studies on nifedipine, furosemide and niclosamide were carried out using hydrogel under various time and pH conditions. The released drug was adjustable as we obtained data on drug release profiles. Nifedipine, furosemide and niclosamide release percentages were 68.9±3.8%, 75.2±3.6% and 58.7±4.2%, respectively. Additionally, all three drugs exhibited marked activity against bacteria. These findings indicate that the synthesized hydrogels are a promising basis for bio­medical applications.

Keywords

Methacrylated β-Cyclodextrin , Niclosamide , Furosemide , Nifedipine

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