Nazofarenks Punch Biyopsi Sonuçlarının Retrospektif Analizi

Year 2018, Volume: 8 Issue: 3, 203 - 206, 01.12.2018

Selçuk Güneş Mustafa Çelik , Burak Olgun İrem Özen Hüseyin Avni Ulusoy

Abstract

Amaç:
Malignite şüphesi nedeniyle yapılan nazofarenks punch biyopsi sonuçlarının
değerlendirilmesi.

Materyal ve Metod: Çalışmaya toplam 491 olgu (231 kadın 260 erkek;
ortalama yaş 36.72±16.91 yıl, aralık 16-90 yıl) dahil edildi. Tüm olguların
dosyaları, yaş, cinsiyet, biyopsi yapılma nedeni ve biyopsi sonuçları açısından
retrospektif olarak değerlendirildi.

Bulgular: Malignite
şüphesi olan ve ayırıcı tanı amacıyla nazofarenks punch biyopsisi yapılan
hastalardan 21’i (%4.2) nazofarenks karsinomu tanısı almıştır. Diğer olguların
patolojik değerlendirme sonuçları; 454 benign patoloji (lenfoid hiperplazi,
kronik lenfoid süreç, (Tornwald kisti) (%92.46), 12 yetersiz materyal (%2.44)
ve 4 granülamatöz hastalık (%0.8) olarak saptanmıştır. Malignite saptanan
olguların ortalama yaşları, patoloji sonucu benign olan olgulara göre istatistiksel
olarak anlamlı düzeyde daha yüksektir (p=0.000). Malign ve benign olguların
cinsiyet dağılımında istatistiksel olarak anlamlı farklılık saptanmamıştır.  

Sonuç: Nazofarenks
kanseri şüphesinde, endoskopik muayenede yer kaplayıcı kitle olmasa da mukoza
ve submukozayı içeren punch biyopsi uygulaması nazofarenks kanserinin erken
tanı ve tedavisine imkan sağlayacaktır.

Keywords

nazofarenks; biyopsi; endoskopi; kanser; punch

Retrospective Analysis of Nasopharynx Punch Biopsy Results

Abstract

Aim: Evaluation
of nasopharyngeal punch biopsy results due to malignancy suspicion.

Material and Method: In
total, 491 patients (231 females 260 males; average age 36.72± 16.91 years; range 16 –90 years)
were included in the present study. All patients files were evaluated in terms of
age, gender, the reason and the results of biopsy.

Results: Nasopharyngeal
carcinoma was diagnosed in 21 patients (4.2%) as a result of nasopharyngeal
punch biopsies performed due to malignancy suspicion and exclusion. Results of
pathological evaluation of other patients; 454 benign pathologies (lymphoid
hyperplasia, chronic lymphoid process, Tornwald cyst) (92.05%), 12 insufficient
material (2.44%) and 4 granulomatous diseases (0.8%), respectively. The mean
age of patients with malignancy was statistically significantly higher than those
with benign pathology (p = 0.000). There was no statistically significant
difference in the gender distribution of malignant and benign cases (p =
0.077).

Conclusion: Taking
punch biopsies containing mucosa and submucosa will provide the early diagnosis
and treatment of nasopharyngeal carcinoma, in spite of the absence of a mass on
endoscopic examination.

Keywords

nasopharynx, biopsy, endoscopy, cancer

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