Research Article
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Nazofarenks Punch Biyopsi Sonuçlarının Retrospektif Analizi

Year 2018, Volume: 8 Issue: 3, 203 - 206, 01.12.2018

Abstract

Amaç:
Malignite şüphesi nedeniyle yapılan nazofarenks punch biyopsi sonuçlarının
değerlendirilmesi.



Materyal ve Metod: Çalışmaya toplam 491 olgu (231 kadın 260 erkek;
ortalama yaş 36.72±16.91 yıl, aralık 16-90 yıl) dahil edildi. Tüm olguların
dosyaları, yaş, cinsiyet, biyopsi yapılma nedeni ve biyopsi sonuçları açısından
retrospektif olarak değerlendirildi.



Bulgular: Malignite
şüphesi olan ve ayırıcı tanı amacıyla nazofarenks punch biyopsisi yapılan
hastalardan 21’i (%4.2) nazofarenks karsinomu tanısı almıştır. Diğer olguların
patolojik değerlendirme sonuçları; 454 benign patoloji (lenfoid hiperplazi,
kronik lenfoid süreç, (Tornwald kisti) (%92.46), 12 yetersiz materyal (%2.44)
ve 4 granülamatöz hastalık (%0.8) olarak saptanmıştır. Malignite saptanan
olguların ortalama yaşları, patoloji sonucu benign olan olgulara göre istatistiksel
olarak anlamlı düzeyde daha yüksektir (p=0.000). Malign ve benign olguların
cinsiyet dağılımında istatistiksel olarak anlamlı farklılık saptanmamıştır.  



Sonuç: Nazofarenks
kanseri şüphesinde, endoskopik muayenede yer kaplayıcı kitle olmasa da mukoza
ve submukozayı içeren punch biyopsi uygulaması nazofarenks kanserinin erken
tanı ve tedavisine imkan sağlayacaktır.

References

  • 1- Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127(12):2893-917.
  • 2- Ho KY, Lee KW, Chai CY, Kuo WR, Wang HM, Chien CY. Early recognition of nasopharyngeal cancer in adults with only otitis media with effusion. J Otolaryngol Head Neck Surg 2008; 37: 362-5.
  • 3- Wei WI, Sham JST. Nasopharyngeal carcinoma. Lancet 2005; 365: 2041-54.
  • 4- Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90.
  • 5- Chang ET, Adami HO. The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev 2006; 15: 1765-77.
  • 6- August M, Dodson TB, Nastri A, Chuang SK. Nasopharyngeal carcinoma: clinical assessment and review of 176 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001; 91: 205-14.
  • 7- Huang WB, Chan JYW, Liu DL. Human papillomavirus and World Health Organization type III nasopharyngeal carcinoma: Multicenter study from an endemic area in Southern China. Cancer 2017 Oct 26. doi: 10.1002/cncr.31031. [Epub ahead of print]
  • 8- Grammatica L, Achille G, Piepoli S, Paradiso A. Early, late symptoms and histological type of nasopharyngeal carcinoma. Oncol Rep 2005;6:1395-8.
  • 9- Tutar B, Berkiten G, Kumral TL,Yıldırım G, Uyar Y, Kamalı GH. Punch Biyopsy Results of Nasopharynx Pathologies: 3 Years Retrospective Analysis. Okmeydani Tip Derg 2014; 30(1): 30-3.
  • 10- Douglas SA, Nelson N, Ashman H. Clinical features of nasopharyngeal carcinoma in Jamaica. Journal of the National Medical Assosication 2003;95:77-81.
  • 11- Başak S, Metin K, Erpek G, Nar H. Erişkin yaş grubunda görülen sekretuar otitis mediada nazal kavite ve nazofarenks patolojileri. KBB ve Baş Boyun Cerrahisi Dergisi 1999;7:1-5.
  • 12- Glynn F, Keogh IJ, Ali TA, Timon CI, Donnelly M. Routine nasopharyngeal biopsy in adults presenting with isolated serous otitis media: is it justified. The Journal of Laryngology and Otology 2006;120:439-41.
  • 13- Pfister DG, Ang KK, Brizel DM, Burtness BA, Busse PM, Caudell JJ, et al. Head and neck cancers, version 2.2013. Featured updates to the NCCN guidelines. J Natl Compr Canc Netw 2013; 11: 917-23.
  • 14- Dang PT, Gubbels SP. Is nasopharyngoscopy necessary in adult-onset otitis media with effusion? Laryngoscope 2013; 123: 2081-2.
  • 15- King AD, Vlantis AC, Bhatia KSS, Zee BC, Woo JK, Tse GM, et al. Primary nasopharyngeal carcinoma: diagnostic accuracy of MR imaging versus that of endoscopy and endoscopic biopsy. Radiology 2011; 258: 531-7.
  • 16- Bercin S, Yalciner G, Muderris T, Gul F, Deger HM, Kiris M. Pathologic Evaluation of Routine Nasopharynx Punch Biopsy in the Adult Population: Is It Really Necessary?. Clin Exp Otorhinolaryngol 2017;10(3):283-7.
  • 17- Özbay İ, Kucur C, Aksoy S, Oğhan F, Külekçi S, Yıldırım N. Nazofarenks Patolojilerinde Punch Biyopsi Sonuçları. J Clin Exp Invest 2016; 7 (1): 83-6.
  • 18- Abu-Ghanem S, Carmel NN, Horowitz G, Yehuda M, Leshno M, Abu-Ghanem Y, et al. Nasopharyngeal biopsy in adults: a large-scale study in a non endemic area. Rhinology 2015;53(2):142-8.

Retrospective Analysis of Nasopharynx Punch Biopsy Results

Year 2018, Volume: 8 Issue: 3, 203 - 206, 01.12.2018

Abstract

Aim: Evaluation
of nasopharyngeal punch biopsy results due to malignancy suspicion.

Material and Method: In
total, 491 patients (231 females 260 males;
average age 36.72± 16.91 years; range 16 –90 years)
were included in the present study. All patients files were evaluated in terms of
age, gender, the reason and the results of biopsy.

Results: Nasopharyngeal
carcinoma was diagnosed in 21 patients (4.2%) as a result of nasopharyngeal
punch biopsies performed due to malignancy suspicion and exclusion. Results of
pathological evaluation of other patients; 454 benign pathologies (lymphoid
hyperplasia, chronic lymphoid process, Tornwald cyst) (92.05%), 12 insufficient
material (2.44%) and 4 granulomatous diseases (0.8%), respectively. The mean
age of patients with malignancy was statistically significantly higher than those
with benign pathology (p = 0.000). There was no statistically significant
difference in the gender distribution of malignant and benign cases (p =
0.077).







Conclusion: Taking
punch biopsies containing mucosa and submucosa will provide the early diagnosis
and treatment of nasopharyngeal carcinoma, in spite of the absence of a mass on
endoscopic examination.

References

  • 1- Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127(12):2893-917.
  • 2- Ho KY, Lee KW, Chai CY, Kuo WR, Wang HM, Chien CY. Early recognition of nasopharyngeal cancer in adults with only otitis media with effusion. J Otolaryngol Head Neck Surg 2008; 37: 362-5.
  • 3- Wei WI, Sham JST. Nasopharyngeal carcinoma. Lancet 2005; 365: 2041-54.
  • 4- Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90.
  • 5- Chang ET, Adami HO. The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev 2006; 15: 1765-77.
  • 6- August M, Dodson TB, Nastri A, Chuang SK. Nasopharyngeal carcinoma: clinical assessment and review of 176 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001; 91: 205-14.
  • 7- Huang WB, Chan JYW, Liu DL. Human papillomavirus and World Health Organization type III nasopharyngeal carcinoma: Multicenter study from an endemic area in Southern China. Cancer 2017 Oct 26. doi: 10.1002/cncr.31031. [Epub ahead of print]
  • 8- Grammatica L, Achille G, Piepoli S, Paradiso A. Early, late symptoms and histological type of nasopharyngeal carcinoma. Oncol Rep 2005;6:1395-8.
  • 9- Tutar B, Berkiten G, Kumral TL,Yıldırım G, Uyar Y, Kamalı GH. Punch Biyopsy Results of Nasopharynx Pathologies: 3 Years Retrospective Analysis. Okmeydani Tip Derg 2014; 30(1): 30-3.
  • 10- Douglas SA, Nelson N, Ashman H. Clinical features of nasopharyngeal carcinoma in Jamaica. Journal of the National Medical Assosication 2003;95:77-81.
  • 11- Başak S, Metin K, Erpek G, Nar H. Erişkin yaş grubunda görülen sekretuar otitis mediada nazal kavite ve nazofarenks patolojileri. KBB ve Baş Boyun Cerrahisi Dergisi 1999;7:1-5.
  • 12- Glynn F, Keogh IJ, Ali TA, Timon CI, Donnelly M. Routine nasopharyngeal biopsy in adults presenting with isolated serous otitis media: is it justified. The Journal of Laryngology and Otology 2006;120:439-41.
  • 13- Pfister DG, Ang KK, Brizel DM, Burtness BA, Busse PM, Caudell JJ, et al. Head and neck cancers, version 2.2013. Featured updates to the NCCN guidelines. J Natl Compr Canc Netw 2013; 11: 917-23.
  • 14- Dang PT, Gubbels SP. Is nasopharyngoscopy necessary in adult-onset otitis media with effusion? Laryngoscope 2013; 123: 2081-2.
  • 15- King AD, Vlantis AC, Bhatia KSS, Zee BC, Woo JK, Tse GM, et al. Primary nasopharyngeal carcinoma: diagnostic accuracy of MR imaging versus that of endoscopy and endoscopic biopsy. Radiology 2011; 258: 531-7.
  • 16- Bercin S, Yalciner G, Muderris T, Gul F, Deger HM, Kiris M. Pathologic Evaluation of Routine Nasopharynx Punch Biopsy in the Adult Population: Is It Really Necessary?. Clin Exp Otorhinolaryngol 2017;10(3):283-7.
  • 17- Özbay İ, Kucur C, Aksoy S, Oğhan F, Külekçi S, Yıldırım N. Nazofarenks Patolojilerinde Punch Biyopsi Sonuçları. J Clin Exp Invest 2016; 7 (1): 83-6.
  • 18- Abu-Ghanem S, Carmel NN, Horowitz G, Yehuda M, Leshno M, Abu-Ghanem Y, et al. Nasopharyngeal biopsy in adults: a large-scale study in a non endemic area. Rhinology 2015;53(2):142-8.
There are 18 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

Selçuk Güneş This is me

Mustafa Çelik

Burak Olgun This is me

İrem Özen This is me

Hüseyin Avni Ulusoy This is me

Publication Date December 1, 2018
Published in Issue Year 2018 Volume: 8 Issue: 3

Cite

APA Güneş, S., Çelik, M., Olgun, B., Özen, İ., et al. (2018). Nazofarenks Punch Biyopsi Sonuçlarının Retrospektif Analizi. Kafkas Journal of Medical Sciences, 8(3), 203-206.
AMA Güneş S, Çelik M, Olgun B, Özen İ, Ulusoy HA. Nazofarenks Punch Biyopsi Sonuçlarının Retrospektif Analizi. KAFKAS TIP BİL DERG. December 2018;8(3):203-206.
Chicago Güneş, Selçuk, Mustafa Çelik, Burak Olgun, İrem Özen, and Hüseyin Avni Ulusoy. “Nazofarenks Punch Biyopsi Sonuçlarının Retrospektif Analizi”. Kafkas Journal of Medical Sciences 8, no. 3 (December 2018): 203-6.
EndNote Güneş S, Çelik M, Olgun B, Özen İ, Ulusoy HA (December 1, 2018) Nazofarenks Punch Biyopsi Sonuçlarının Retrospektif Analizi. Kafkas Journal of Medical Sciences 8 3 203–206.
IEEE S. Güneş, M. Çelik, B. Olgun, İ. Özen, and H. A. Ulusoy, “Nazofarenks Punch Biyopsi Sonuçlarının Retrospektif Analizi”, KAFKAS TIP BİL DERG, vol. 8, no. 3, pp. 203–206, 2018.
ISNAD Güneş, Selçuk et al. “Nazofarenks Punch Biyopsi Sonuçlarının Retrospektif Analizi”. Kafkas Journal of Medical Sciences 8/3 (December 2018), 203-206.
JAMA Güneş S, Çelik M, Olgun B, Özen İ, Ulusoy HA. Nazofarenks Punch Biyopsi Sonuçlarının Retrospektif Analizi. KAFKAS TIP BİL DERG. 2018;8:203–206.
MLA Güneş, Selçuk et al. “Nazofarenks Punch Biyopsi Sonuçlarının Retrospektif Analizi”. Kafkas Journal of Medical Sciences, vol. 8, no. 3, 2018, pp. 203-6.
Vancouver Güneş S, Çelik M, Olgun B, Özen İ, Ulusoy HA. Nazofarenks Punch Biyopsi Sonuçlarının Retrospektif Analizi. KAFKAS TIP BİL DERG. 2018;8(3):203-6.