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Gebelik Anemisinin Perinatal Sonuçlara Etkisinin Değerlendirilmesi

Year 2020, Volume: 10 Issue: 2, 131 - 135, 01.08.2020

Abstract

Amaç: Çalışmada anemisi olan gebelerde, gebelik anemisinin perinatal sonuçlara etkisini araştırmak amaçlanmıştır.
Materyal ve Metot: Bu retrospektif çalışmada, 1 Ocak 2017–31 Aralık 2018 tarihleri arasında bir Eğitim ve Araştırma Hastanesi Kadın Hastalıkları ve Doğum Kliniğinde doğumu gerçekleştirilen 933 hastadan elde edilen veriler kullanıldı. Çalışmaya hemoglobin (Hb) değeri 11 g/dL’nin altında 305 gebe kadın (anemik grup) ve Hb değeri 11 g/dL’nin üzerinde 628 gebe (kontrol grup) dâhil edildi. Dosyalardan hastaların yaşları, gebelik öyküleri, gravida, parite, doğum haftası, yenidoğanın kilosu, bebek cinsiyetleri, doğum şekli, annenin hemoglobin, 1. ve 5. dakika Apgar skorları, oligohidroamnioz, intrauterin gelişme kısıtlılığı sıklığı (IUGR) ve preterm doğum, intra uterin ölü doğum olup olmadığı gibi veriler elde edildi. Anemik olan ve normal hemoglobin seviyelerine sahip gebelerin gebelik seyri ve perinatal sonuçları karşılaştırıldı.
Bulgular: Gruplar arasında parite, gravida, yaş, doğum haftası, intrauterin ölü fetüs doğum oranı, ortalama bebek doğum ağırlığı, normal spontan vajinal doğum, sezaryen doğum, bebek cinsiyetleri, 1. ve 5. dakika Apgar skorları açısından istatistiksel olarak anlamlı bir fark saptanmadı (p>0,05). İki grup arasında oligohidroamnioz, intrauterin gelişme kısıtlılığı sıklığı (IUGR) ve preterm doğum oranı açısından istatistiksel olarak anlamlı fark bulundu (p<0,05). Anemik grupta preterm eylem, IUGR, oligohidroamnioz oranları (sırasıyla %11,8; %9,5; %13,1) kontrol grubu oranlarından (%3,3; %2,8; %5,5) daha yüksek bulunmuştur.
Sonuç: Anemi özellikle düşük sosyoekonomik düzeydeki ülkelerde gebelik sürecini etkileyen yaygın bir durum olmakla beraber gebelik anemisinin antenatal takipler sırasında belirlenmesi ve tedavisi perinatal komplikasyonların azaltılması bakımından önemlidir. Anemisi olan gebelere demir desteği verilmeli ve anemiyi etkileyen beslenmeyle ilişkili faktörler konusunda üzere ilgili sağlık personeli tarafından bilgilendirilmelidir.

References

  • 1. De Benoist B, Cogswell M, Egli I, McLean E. Anemia. In: De Benoist B, Cogswell M, Egli I, McLean E, editors. Worldwide prevalence of anaemia 1993–2005. WHO Global Database of anaemia. Switzerland; 2008. p.1.
  • 2. Balarajan Y, Ramakrishnan U, Özaltin E, Shankar AH, Subramanian SV. Anaemia in low-income and middle-income countries. The Lancet 2011;378(9809):2123–35.
  • 3. Cunningham FG, Leveno KJ, Bloom SL, Dashe JS, Hoffman BL, Casey BM, et al. Williams Obstetrics Hot Edition. US: The McGraw-Hill Companies 2001;47:1308–10.
  • 4. WHO, Unicef. Unu. Iron deficiency anaemia: assessment, prevention and control, a guide for programme managers. Switzerland, Geneva: World Health Organization, 2001:1–114.
  • 5. Scholl TO. Iron status during pregnancy: setting the stage for mother and infant. Am J Clin Nutr 2005;81(5):1218–22.
  • 6. Breymann C. Iron Deficiency Anemia in Pregnancy. Semin Hematol 2015;52:339–47.
  • 7. Gebelerde demir destek programı uygulaması genelgesi 2007/6. Ana Çocuk Sağlığı ve Aile Planlaması Genel Müdürlüğü, T. C. Sağlık Bakanlığı. https://www.saglik.gov. tr/TR,11100/gebelerde-demir-destek-programi-uygulumasigenelgesi-2007--6.html. 2007 [accessed 13 07 20]
  • 8. Brabin BJ, Hakimi M, Pelletier D. An analysis of anemia and pregnancy-related maternal mortality. J Nutrition 2001;131(2):604–15.
  • 9. Rasmussen KM. Is there a causal relationship between iron deficiency or iron-deficiency anemia and weight at birth, length of gestation and perinatal mortality? J Nutrition 2001;131(2):590–603.
  • 10. Anderson MA, Dewey KG, Frongillo E, Garza C, Haschke F, Kramer M, et al. An evaluation of infant growth: the use and interpretation of anthropometry in infants. Bull World Health Organization 1995;73(2):165–74.
  • 11. Getnet G. Adherence to Iron/Folic Acid Supplementation and Associated Factors among Pregnant Women Attending Antenatal Care in Fogera District, North-West Ethiopia:Community Based Cross Sectional Study (Doctoral dissertation); 2019.
  • 12. Chaparro CM, Suchdev PS. Anemia epidemiology, pathophysiology, and etiology in low-and middle-income countries. Ann N Y Acad Sci 2019;1450(1):15.
  • 13. Allen LH. Biological mechanisms that might underlie iron’s effects on fetal growth and preterm birth. J Nutrition 2001;131(2):581–9.
  • 14. Nsereko E, Uwase A, Mukabutera A, Muvunyi CM, Rulisa S, Ntirushwa D, et al. Maternal genitourinary infections and poor nutritional status increase risk of preterm birth in Gasabo District, Rwanda: a prospective, longitudinal, cohort study. BMC Pregnancy Childbirth 2020;20:1–3.
  • 15. Suryanarayana R, Chandrappa M, Santhuram AN, Prathima S, Sheela SR. Prospective study on prevalence of anemia of pregnant women and its outcome: A community based study. J Fam Med Primary Care 2017;6(4):739.
  • 16. Ardic C, Usta O, Omar E, Yıldız C, Memis E, Zeren Öztürk G. Relationship between anaemia during pregnancy and preterm delivery. J Obstet Gynaecol 019;39(7):903–6.
  • 17. Kant S, Kaur R, Goel AD, Malhotra S, Haldar P, Kumar R. Anemia at the time of delivery and its association with pregnancy outcomes: A study from a secondary care hospital in Haryana, India. Indian J Pub Health 2018;62(4):315.
  • 18. Beckert RH, Baer RJ, Anderson JG, Jelliffe-Pawlowski LL, Rogers EE. Maternal anemia and pregnancy outcomes: a population-based study. J Perinatology 2019;39(7):911–19.
  • 19. Sovizi B, Kermani Mokhar H, Eftekhari Yazdi M. The Relationship between Maternal Haemoglobin and Haematocrit with Low Birth Weight and Preterm Labour. J Midwifery Reprod Health 2019;7(1):1577–83.
  • 20. Chu FC, Shao SS, Lo LM, Hung TH. Association between maternal anemia at admission for delivery and adverse perinatal outcomes. J Chinese Med Assoc 2020;83(4):402–7.
  • 21. Anand P, Gupta R, Sudan JK. Prevalence of Low Birth Weight and Associated Maternal Risk Factors among the Term Neonates during Normal Deliveries in Jammu, J&K. Int J Health Sci Res 2019;9(8):376–83.
  • 22. Prajapati R, Shrestha S, Bhandari N. Prevalence and Associated Factors of Low Birth Weight among Newborns in a Tertiary Level Hospital in Nepal. Kathmandu Univ Med J 2018;61(1):49–52.
  • 23. Endalamaw A, Engeda EH, Ekubagewargies DT, Belay GM, Tefera MA. Low birth weight and its associated factors in Ethiopia: a systematic review and meta-analysis. Italian J Pediatrics 2018;44(1):141.
  • 24. Rahmati S, Delpishe A, Azami M, Ahmadi MRH, Sayehmiri K. Maternal Anemia during pregnancy and infant low birth weight: A systematic review and Meta-analysis. Int J Reprod BioMed 2017;15(3):125.
  • 25. Moos T, Skjørringe T, Thomsen LL. Iron deficiency and iron treatment in the fetal developing brain-a pilot study introducing an experimental rat model. Reprod Health 2018;15(1):93.
  • 26. Drukker L, Hants Y, Farkash R, Ruchlemer R, Samueloff A, Grisaru-Granovsky S. Iron deficiency anemia at admission for labor and delivery is associated with an increased risk for Cesarean section and adverse maternal and neonatal outcomes. Transfusion 2015;55(12):2799–806.
  • 27. Smith C, Teng F, Branch E, Chu S, Joseph KS. Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy. Obstet Gynecol 2019;134(6):1234–44.
  • 28. Cantürk FK, Dağlı SS. Maternal Aneminin Perinatal Sonuçlara Etkisi. Jinekoloji-Obstetrik ve Neonatoloji Tıp Derg 2019;16(1):22–6.
  • 29. Lumbanraja SN, Yaznil MR, Siregar DIS, Sakina A. The Correlation between Hemoglobin Concentration during Pregnancy with the Maternal and Neonatal Outcome. Open Access Macedonian J Med Sci 2019;7(4):594.
  • 30. Patel A, Prakash AA, Das PK, Gupta S, Pusdekar YV, Hibberd PL. Gebelik sonuçlarının belirleyicileri olarak maternal anemi ve düşük kilo: Hindistan’ın doğusundaki Maharashtra kırsalında kohort çalışması. BMJ 2018;8(8):e021623.
  • 31. Parks S, Hoffman MK, Goudar SS, Patel A, Saleem S, Ali SA, et al. Maternal anaemia and maternal, fetal, and neonatal outcomes in a prospective cohort study in India and Pakistan. BJOG. An Int J Obstet Gynaecol 2019;126(6):737–43.
  • 32. Abraha I, Bonacini MI, Montedori A, Di Renzo GC, Angelozzi P, Micheli M, et al. Oral iron-based interventions for prevention of critical outcomes in pregnancy and postnatal care: An overview and update of systematic reviews. J Evidence-BasedMed 2019;12(2):155–66.
Year 2020, Volume: 10 Issue: 2, 131 - 135, 01.08.2020

Abstract

References

  • 1. De Benoist B, Cogswell M, Egli I, McLean E. Anemia. In: De Benoist B, Cogswell M, Egli I, McLean E, editors. Worldwide prevalence of anaemia 1993–2005. WHO Global Database of anaemia. Switzerland; 2008. p.1.
  • 2. Balarajan Y, Ramakrishnan U, Özaltin E, Shankar AH, Subramanian SV. Anaemia in low-income and middle-income countries. The Lancet 2011;378(9809):2123–35.
  • 3. Cunningham FG, Leveno KJ, Bloom SL, Dashe JS, Hoffman BL, Casey BM, et al. Williams Obstetrics Hot Edition. US: The McGraw-Hill Companies 2001;47:1308–10.
  • 4. WHO, Unicef. Unu. Iron deficiency anaemia: assessment, prevention and control, a guide for programme managers. Switzerland, Geneva: World Health Organization, 2001:1–114.
  • 5. Scholl TO. Iron status during pregnancy: setting the stage for mother and infant. Am J Clin Nutr 2005;81(5):1218–22.
  • 6. Breymann C. Iron Deficiency Anemia in Pregnancy. Semin Hematol 2015;52:339–47.
  • 7. Gebelerde demir destek programı uygulaması genelgesi 2007/6. Ana Çocuk Sağlığı ve Aile Planlaması Genel Müdürlüğü, T. C. Sağlık Bakanlığı. https://www.saglik.gov. tr/TR,11100/gebelerde-demir-destek-programi-uygulumasigenelgesi-2007--6.html. 2007 [accessed 13 07 20]
  • 8. Brabin BJ, Hakimi M, Pelletier D. An analysis of anemia and pregnancy-related maternal mortality. J Nutrition 2001;131(2):604–15.
  • 9. Rasmussen KM. Is there a causal relationship between iron deficiency or iron-deficiency anemia and weight at birth, length of gestation and perinatal mortality? J Nutrition 2001;131(2):590–603.
  • 10. Anderson MA, Dewey KG, Frongillo E, Garza C, Haschke F, Kramer M, et al. An evaluation of infant growth: the use and interpretation of anthropometry in infants. Bull World Health Organization 1995;73(2):165–74.
  • 11. Getnet G. Adherence to Iron/Folic Acid Supplementation and Associated Factors among Pregnant Women Attending Antenatal Care in Fogera District, North-West Ethiopia:Community Based Cross Sectional Study (Doctoral dissertation); 2019.
  • 12. Chaparro CM, Suchdev PS. Anemia epidemiology, pathophysiology, and etiology in low-and middle-income countries. Ann N Y Acad Sci 2019;1450(1):15.
  • 13. Allen LH. Biological mechanisms that might underlie iron’s effects on fetal growth and preterm birth. J Nutrition 2001;131(2):581–9.
  • 14. Nsereko E, Uwase A, Mukabutera A, Muvunyi CM, Rulisa S, Ntirushwa D, et al. Maternal genitourinary infections and poor nutritional status increase risk of preterm birth in Gasabo District, Rwanda: a prospective, longitudinal, cohort study. BMC Pregnancy Childbirth 2020;20:1–3.
  • 15. Suryanarayana R, Chandrappa M, Santhuram AN, Prathima S, Sheela SR. Prospective study on prevalence of anemia of pregnant women and its outcome: A community based study. J Fam Med Primary Care 2017;6(4):739.
  • 16. Ardic C, Usta O, Omar E, Yıldız C, Memis E, Zeren Öztürk G. Relationship between anaemia during pregnancy and preterm delivery. J Obstet Gynaecol 019;39(7):903–6.
  • 17. Kant S, Kaur R, Goel AD, Malhotra S, Haldar P, Kumar R. Anemia at the time of delivery and its association with pregnancy outcomes: A study from a secondary care hospital in Haryana, India. Indian J Pub Health 2018;62(4):315.
  • 18. Beckert RH, Baer RJ, Anderson JG, Jelliffe-Pawlowski LL, Rogers EE. Maternal anemia and pregnancy outcomes: a population-based study. J Perinatology 2019;39(7):911–19.
  • 19. Sovizi B, Kermani Mokhar H, Eftekhari Yazdi M. The Relationship between Maternal Haemoglobin and Haematocrit with Low Birth Weight and Preterm Labour. J Midwifery Reprod Health 2019;7(1):1577–83.
  • 20. Chu FC, Shao SS, Lo LM, Hung TH. Association between maternal anemia at admission for delivery and adverse perinatal outcomes. J Chinese Med Assoc 2020;83(4):402–7.
  • 21. Anand P, Gupta R, Sudan JK. Prevalence of Low Birth Weight and Associated Maternal Risk Factors among the Term Neonates during Normal Deliveries in Jammu, J&K. Int J Health Sci Res 2019;9(8):376–83.
  • 22. Prajapati R, Shrestha S, Bhandari N. Prevalence and Associated Factors of Low Birth Weight among Newborns in a Tertiary Level Hospital in Nepal. Kathmandu Univ Med J 2018;61(1):49–52.
  • 23. Endalamaw A, Engeda EH, Ekubagewargies DT, Belay GM, Tefera MA. Low birth weight and its associated factors in Ethiopia: a systematic review and meta-analysis. Italian J Pediatrics 2018;44(1):141.
  • 24. Rahmati S, Delpishe A, Azami M, Ahmadi MRH, Sayehmiri K. Maternal Anemia during pregnancy and infant low birth weight: A systematic review and Meta-analysis. Int J Reprod BioMed 2017;15(3):125.
  • 25. Moos T, Skjørringe T, Thomsen LL. Iron deficiency and iron treatment in the fetal developing brain-a pilot study introducing an experimental rat model. Reprod Health 2018;15(1):93.
  • 26. Drukker L, Hants Y, Farkash R, Ruchlemer R, Samueloff A, Grisaru-Granovsky S. Iron deficiency anemia at admission for labor and delivery is associated with an increased risk for Cesarean section and adverse maternal and neonatal outcomes. Transfusion 2015;55(12):2799–806.
  • 27. Smith C, Teng F, Branch E, Chu S, Joseph KS. Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy. Obstet Gynecol 2019;134(6):1234–44.
  • 28. Cantürk FK, Dağlı SS. Maternal Aneminin Perinatal Sonuçlara Etkisi. Jinekoloji-Obstetrik ve Neonatoloji Tıp Derg 2019;16(1):22–6.
  • 29. Lumbanraja SN, Yaznil MR, Siregar DIS, Sakina A. The Correlation between Hemoglobin Concentration during Pregnancy with the Maternal and Neonatal Outcome. Open Access Macedonian J Med Sci 2019;7(4):594.
  • 30. Patel A, Prakash AA, Das PK, Gupta S, Pusdekar YV, Hibberd PL. Gebelik sonuçlarının belirleyicileri olarak maternal anemi ve düşük kilo: Hindistan’ın doğusundaki Maharashtra kırsalında kohort çalışması. BMJ 2018;8(8):e021623.
  • 31. Parks S, Hoffman MK, Goudar SS, Patel A, Saleem S, Ali SA, et al. Maternal anaemia and maternal, fetal, and neonatal outcomes in a prospective cohort study in India and Pakistan. BJOG. An Int J Obstet Gynaecol 2019;126(6):737–43.
  • 32. Abraha I, Bonacini MI, Montedori A, Di Renzo GC, Angelozzi P, Micheli M, et al. Oral iron-based interventions for prevention of critical outcomes in pregnancy and postnatal care: An overview and update of systematic reviews. J Evidence-BasedMed 2019;12(2):155–66.
There are 32 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Research Article
Authors

Kazım Uçkan This is me

İzzet Çeleğen This is me

Taner Uçkan This is me

Publication Date August 1, 2020
Published in Issue Year 2020 Volume: 10 Issue: 2

Cite

APA Uçkan, K., Çeleğen, İ., & Uçkan, T. (2020). Gebelik Anemisinin Perinatal Sonuçlara Etkisinin Değerlendirilmesi. Kafkas Journal of Medical Sciences, 10(2), 131-135.
AMA Uçkan K, Çeleğen İ, Uçkan T. Gebelik Anemisinin Perinatal Sonuçlara Etkisinin Değerlendirilmesi. KAFKAS TIP BİL DERG. August 2020;10(2):131-135.
Chicago Uçkan, Kazım, İzzet Çeleğen, and Taner Uçkan. “Gebelik Anemisinin Perinatal Sonuçlara Etkisinin Değerlendirilmesi”. Kafkas Journal of Medical Sciences 10, no. 2 (August 2020): 131-35.
EndNote Uçkan K, Çeleğen İ, Uçkan T (August 1, 2020) Gebelik Anemisinin Perinatal Sonuçlara Etkisinin Değerlendirilmesi. Kafkas Journal of Medical Sciences 10 2 131–135.
IEEE K. Uçkan, İ. Çeleğen, and T. Uçkan, “Gebelik Anemisinin Perinatal Sonuçlara Etkisinin Değerlendirilmesi”, KAFKAS TIP BİL DERG, vol. 10, no. 2, pp. 131–135, 2020.
ISNAD Uçkan, Kazım et al. “Gebelik Anemisinin Perinatal Sonuçlara Etkisinin Değerlendirilmesi”. Kafkas Journal of Medical Sciences 10/2 (August 2020), 131-135.
JAMA Uçkan K, Çeleğen İ, Uçkan T. Gebelik Anemisinin Perinatal Sonuçlara Etkisinin Değerlendirilmesi. KAFKAS TIP BİL DERG. 2020;10:131–135.
MLA Uçkan, Kazım et al. “Gebelik Anemisinin Perinatal Sonuçlara Etkisinin Değerlendirilmesi”. Kafkas Journal of Medical Sciences, vol. 10, no. 2, 2020, pp. 131-5.
Vancouver Uçkan K, Çeleğen İ, Uçkan T. Gebelik Anemisinin Perinatal Sonuçlara Etkisinin Değerlendirilmesi. KAFKAS TIP BİL DERG. 2020;10(2):131-5.