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Pasif Sigara İçici Bebeklerde Serum Antioksidan Vitamin Düzeyleri ve Beslenme Tipiyle İlişkisi

Year 2021, Volume: 11 Issue: 1, 16 - 22, 01.04.2021

Abstract

Amaç: Sigara ve sigara dumanında birçok toksik madde bulunmaktadır. Bu toksik maddeler sigara içen kişilerin ve çevresindekilerin sağlığını etkilemektedir. Sigara ve pasif sigara içiciliğinin çocuk sağlığı üzerinde birçok olumsuz etkileri bulunmaktadır. Sigaranın, sağlık üzerine olan olumsuz etkilerinden büyüme sürecinde olan çocuklar ve özellikle infantlar etkilenmektedir. Sigara dumanında bulunan serbest radikaller vücudumuzdaki tüm dokulara ve hücresel yapılara zarar verebilir. Serbest radikallerin artmasıyla oluşan oksidatif stres, antioksidan sistemin bir parçası olan vitamin A, C, E düzeylerinde azalmaya neden olmaktadır. Bu çalışmada, pasif sigara içici bebeklerin serum antioksidan vitamin (A, C, E) düzeylerinin değerlendirilmesi amaçlandı.
Materyal ve Metot: Çalışmaya üç aylık olan 78 bebek çalışmaya dâhil edilmiştir. Aynı bebekler altı ayda yeniden değerlendirilmiştir. Annelere bebeklerin beslenmeleri ve evde sigaraya maruziyetleri soruldu. Bebeklerin 3.–6. aydaki serum vitamin A, C, E düzeyleri ve idrarda kotinin/kreatinin oranları ölçüldü. 3. ve 6. aylarda anne sütünde vitamin A, C, E düzeyleri bakıldı.
Bulgular: Annesi sigara içen bebeklerin 3. ve 6. aydaki serum vitamin A, C, E düzeyleri annesi aktif-pasif sigara içmeyen bebeklere göre daha düşüktü. Annesi sigara içen bebeklerin idrar kotinin/ kreatinin oranları, annesi aktif-pasif sigara içmeyen bebeklerin idrar kotinin/kreatinin oranlarına göre daha yüksekti. Bebeklerin sigaraya maruziyetlerine göre 3. ve 6. aydaki beslenmelerinde farklılık yoktu. Annesi sigara içenlerin anne sütündeki vitamin A, C, E düzeyleri, annesi aktif-pasif sigara içmeyenlere göre belirgin düşüktü.
Sonuç: Bebeklerin sigaraya maruziyetleri; antioksidan vitamin düzeylerini etkilemektedir. Sigaraya maruziyetin bir göstergesi olan idrar kotinin/kreatinin oranları pasif sigara içici bebeklerde daha yüksektir. Ayrıca annelerin sigaraya maruziyetleri; anne sütündeki vitamin A, C, E düzeylerini etkilemektedir.

References

  • 1. Erguder, T. Tobacco use and prevention programs (Tütün Kullanımı ve Önleme Programları). Halk Sağlığı İle İlgili Güncel Sorunlar ve Yaklaşımlar, 2009;22-25.
  • 2. Örsel O. Tütün içeriği, farmako-kinetiği ve tütün ürünleri. Ed (Karadağ M, Bilgiç H) Tütün Kontrolü. İstanbul Türk Toraks Derneği, 2010;131-40
  • 3. Bartal M. Health effects of tobacco use and exposure. Monaldi Arch Chest Dis 2001;56(6):545-54
  • 4. Ayçicek A, Koçyiğit A. İncreased oxidative stres in infants exposed to passive smoking. Eur J. Pediatr 2005;164:777-8
  • 5. Kaleli S. Sigaranın sağlık üzerine zararlı etkileri. Fırat Sağlık Hizmetleri Dergisi 2010;5(14):39-56
  • 6. Lim R, Sobey CG. Maternal nicotine exposure and fetal programming of vasculer oxidative stress in adult offspring. British Journal of Pharmacology 2011;164:1397-99
  • 7. Bolisetty S, Naidoo D, Lui K, Koh TH, Watson D, Montgomery R et all. Postnatal changes in maternal and neonatal plasma antioxidant vitamins and the influence of smoking. Arch Dis Child Fetal Neonatal Ed 2002;86:36-40
  • 8. Yilmaz G, Isık Agras P, Hızlı S, Karacan C, Besler HT, Yurdakok K et al. The effect of passive smoking and breast-feding on serum antioxidant vitamin (A, C, E) levels in infants. Acta Paediatr. 2009;98(3):531-6
  • 9. Jendryczko A, Szpyrka G, Gruszczynski J, Kozowicz M. Cigarette smoke exposure of school children: effect of passive smoking and vitamin e supplementation on blood antioxidant status. Neoplasma 1993;40:199-203
  • 10. Harlap S, Davies AM. İnfant admissions to the hospital and maternal smoking. Lancet 1974;1:529-32
  • 11. Becker AB, Manfreda J, Ferguson AC, Dimich-ward H, Watson WT, Chanyeung M. Breast-feeding and environmental tobacco smoke exposure. Arch Pediatr Adolesc Med. 1999;153:689-691
  • 12. Luck W, Nau H. Exposure of the fetus, neonate, and nursed infant to nicotine and cotinine from maternal smoking. New Eng J Med. 1984;311:672
  • 13. Dahlström A, Lundell B, Curvall M, Thapper L. Nicotine and cotinine concentrations in the nursing mother and her infant. Acta Paediatr Scand. 1990;79(2):142-7.
  • 14. Batstra L, Neeleman J, Hadders-Algra M. Can breast feeding modify the adverse effects of smoking during pregnancy on the child's cognitive development?. Journal of Epidemiology & Community Health. 2003;57(6):403-4.
  • 15. Mennella JA, Yourshaw LM, Morgan LK. Breastfeeing and smoking short-term effects on infant feeding and sleep. American Acedemy of Pediatrics 2007;120(3):497-502
  • 16. Bruno RS, Ramakrishnan R, Montine TJ, Bray TM, Traber MG. Alpha-Tocopherol disappearance is faster in cigarette smokers and is inversely related to their ascorbic acid status. Am J Clin Nutr 2005;81:95-103.
  • 17. Tribble DL, Giuliano LJ, Fortmann SP. Reduced plasma ascorbic acid concentrations in non-smokers regularly exposed to environmental tobacco smoke. Am J Clin Nutr 1993;58:88-90
  • 18. Preston AM, Rodriguez C, Rivera CE, Sahai H. Influence of environmental tobacco smoke on vitamin C status in children. Am J Clin Nutr 2003;77:167-72.
  • 19. Strauss RS. Environmental tobacco smoke and serum vitamin C levels in children. Pediatrics 2001;107:540-42.
  • 20. Alberg AJ, Chen JC, Zhao H, Hoffman SC, Comstock GW, Helzlsouer KJ. Household exposure to passive cigarette smoking and serum micronutrient concentrations. Am J Clin Nutr 2000;72:1576-82.
  • 21. Ortega RM, López-Sobaler AM, Quintas ME, Martínez RM, Andrés P. The influence of smoking on vitamin c status during the third trimester of pregnancy and vitamin c levels in maternal milk. Journal of The American Callege of Nutrıtıon 1998;17(4):379-84
  • 22. Ortega RM, López-Sobaler AM, Martínez RM, Andrés P, Quintas ME. Influence of smoking on vitamin E status during the third trimester of pregnancy and on breast-milk tocopherol concentrations in spanish women. Am J Clin Nutr 1998;68:662-67.
  • 23. Boersma ER, Offringa PJ, Muskiet FA, Chase WM, Simmons IJ. Vitamin E, lipid fractions, and fatty acid composition of colostrum, transitional milk, and mature milk: an international comparative study. Am J Clin Nutr 1991;53(5):1197-204.

The Relationship Between Serum Antioxidant Vitamin Levels and Type of Nutrition in Passive Smoker Infants

Year 2021, Volume: 11 Issue: 1, 16 - 22, 01.04.2021

Abstract

Aim: There are many toxic substances in cigarette smoke and cigarette. These toxic substances affect the health of smokers and people around. Smoking and passive smoking exposure adverse effects on the health of many children. One of the adverse effects of smoking on health directly influences children in the growing period and especially on infants. The free radicals found in cigarette smoke can damage all the tissues in our body and cellular structures. Oxidative stress due to the increased free radicals cause a decrease in the levels of A, C, E vitamins which are part of antioxidant system. In this study, we aimed to evaluate serum antioxidant vitamin (A, C, E) levels of passive smokers.
Material and Method: The study includes 78 babies at 3 months. The same infants were re-evaluated in the at 6 months. Feeding of babies’ exposure to the cigarette were asked to the mothers. Serum vitamin A, C and E levels and urinary cotinine/creatinine ratios were measured at third and sixth months. Breastmilk vitamin A, C, E levels were measured at third and sixth months.
Results: Infants with smoking mothers at 3 and 6 months, serum vitamin A, C, E levels were lower than other babies with activepassive non-smoking mothers. Infants with smoking mothers have urinary cotinine/creatinine ratios are higher than that of activepassive non-smoking mothers. There was no difference in terms of nutrition with respect to smoke exposure at 3 and 6 months. Infants with smoking mothers have vitamins A, C, E levels lower than that of active-passive non-smoking mothers.
Conclusion: Smoke exposure of infants affects antioxidant vitamin levels of the babies. Urinary cotinine/creatinine ratio, an indicator of exposure to smoke, are higher in infants of passive smokers. In addition, mothers’ exposure to smoke affects the vitamins A, C, E levels of mother’s milk

References

  • 1. Erguder, T. Tobacco use and prevention programs (Tütün Kullanımı ve Önleme Programları). Halk Sağlığı İle İlgili Güncel Sorunlar ve Yaklaşımlar, 2009;22-25.
  • 2. Örsel O. Tütün içeriği, farmako-kinetiği ve tütün ürünleri. Ed (Karadağ M, Bilgiç H) Tütün Kontrolü. İstanbul Türk Toraks Derneği, 2010;131-40
  • 3. Bartal M. Health effects of tobacco use and exposure. Monaldi Arch Chest Dis 2001;56(6):545-54
  • 4. Ayçicek A, Koçyiğit A. İncreased oxidative stres in infants exposed to passive smoking. Eur J. Pediatr 2005;164:777-8
  • 5. Kaleli S. Sigaranın sağlık üzerine zararlı etkileri. Fırat Sağlık Hizmetleri Dergisi 2010;5(14):39-56
  • 6. Lim R, Sobey CG. Maternal nicotine exposure and fetal programming of vasculer oxidative stress in adult offspring. British Journal of Pharmacology 2011;164:1397-99
  • 7. Bolisetty S, Naidoo D, Lui K, Koh TH, Watson D, Montgomery R et all. Postnatal changes in maternal and neonatal plasma antioxidant vitamins and the influence of smoking. Arch Dis Child Fetal Neonatal Ed 2002;86:36-40
  • 8. Yilmaz G, Isık Agras P, Hızlı S, Karacan C, Besler HT, Yurdakok K et al. The effect of passive smoking and breast-feding on serum antioxidant vitamin (A, C, E) levels in infants. Acta Paediatr. 2009;98(3):531-6
  • 9. Jendryczko A, Szpyrka G, Gruszczynski J, Kozowicz M. Cigarette smoke exposure of school children: effect of passive smoking and vitamin e supplementation on blood antioxidant status. Neoplasma 1993;40:199-203
  • 10. Harlap S, Davies AM. İnfant admissions to the hospital and maternal smoking. Lancet 1974;1:529-32
  • 11. Becker AB, Manfreda J, Ferguson AC, Dimich-ward H, Watson WT, Chanyeung M. Breast-feeding and environmental tobacco smoke exposure. Arch Pediatr Adolesc Med. 1999;153:689-691
  • 12. Luck W, Nau H. Exposure of the fetus, neonate, and nursed infant to nicotine and cotinine from maternal smoking. New Eng J Med. 1984;311:672
  • 13. Dahlström A, Lundell B, Curvall M, Thapper L. Nicotine and cotinine concentrations in the nursing mother and her infant. Acta Paediatr Scand. 1990;79(2):142-7.
  • 14. Batstra L, Neeleman J, Hadders-Algra M. Can breast feeding modify the adverse effects of smoking during pregnancy on the child's cognitive development?. Journal of Epidemiology & Community Health. 2003;57(6):403-4.
  • 15. Mennella JA, Yourshaw LM, Morgan LK. Breastfeeing and smoking short-term effects on infant feeding and sleep. American Acedemy of Pediatrics 2007;120(3):497-502
  • 16. Bruno RS, Ramakrishnan R, Montine TJ, Bray TM, Traber MG. Alpha-Tocopherol disappearance is faster in cigarette smokers and is inversely related to their ascorbic acid status. Am J Clin Nutr 2005;81:95-103.
  • 17. Tribble DL, Giuliano LJ, Fortmann SP. Reduced plasma ascorbic acid concentrations in non-smokers regularly exposed to environmental tobacco smoke. Am J Clin Nutr 1993;58:88-90
  • 18. Preston AM, Rodriguez C, Rivera CE, Sahai H. Influence of environmental tobacco smoke on vitamin C status in children. Am J Clin Nutr 2003;77:167-72.
  • 19. Strauss RS. Environmental tobacco smoke and serum vitamin C levels in children. Pediatrics 2001;107:540-42.
  • 20. Alberg AJ, Chen JC, Zhao H, Hoffman SC, Comstock GW, Helzlsouer KJ. Household exposure to passive cigarette smoking and serum micronutrient concentrations. Am J Clin Nutr 2000;72:1576-82.
  • 21. Ortega RM, López-Sobaler AM, Quintas ME, Martínez RM, Andrés P. The influence of smoking on vitamin c status during the third trimester of pregnancy and vitamin c levels in maternal milk. Journal of The American Callege of Nutrıtıon 1998;17(4):379-84
  • 22. Ortega RM, López-Sobaler AM, Martínez RM, Andrés P, Quintas ME. Influence of smoking on vitamin E status during the third trimester of pregnancy and on breast-milk tocopherol concentrations in spanish women. Am J Clin Nutr 1998;68:662-67.
  • 23. Boersma ER, Offringa PJ, Muskiet FA, Chase WM, Simmons IJ. Vitamin E, lipid fractions, and fatty acid composition of colostrum, transitional milk, and mature milk: an international comparative study. Am J Clin Nutr 1991;53(5):1197-204.
There are 23 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Research Article
Authors

Döndü Ülker Üstebay This is me

Handan Alp This is me

Sefer Üstebay This is me

Publication Date April 1, 2021
Published in Issue Year 2021 Volume: 11 Issue: 1

Cite

APA Üstebay, D. Ü., Alp, H., & Üstebay, S. (2021). Pasif Sigara İçici Bebeklerde Serum Antioksidan Vitamin Düzeyleri ve Beslenme Tipiyle İlişkisi. Kafkas Journal of Medical Sciences, 11(1), 16-22.
AMA Üstebay DÜ, Alp H, Üstebay S. Pasif Sigara İçici Bebeklerde Serum Antioksidan Vitamin Düzeyleri ve Beslenme Tipiyle İlişkisi. KAFKAS TIP BİL DERG. April 2021;11(1):16-22.
Chicago Üstebay, Döndü Ülker, Handan Alp, and Sefer Üstebay. “Pasif Sigara İçici Bebeklerde Serum Antioksidan Vitamin Düzeyleri Ve Beslenme Tipiyle İlişkisi”. Kafkas Journal of Medical Sciences 11, no. 1 (April 2021): 16-22.
EndNote Üstebay DÜ, Alp H, Üstebay S (April 1, 2021) Pasif Sigara İçici Bebeklerde Serum Antioksidan Vitamin Düzeyleri ve Beslenme Tipiyle İlişkisi. Kafkas Journal of Medical Sciences 11 1 16–22.
IEEE D. Ü. Üstebay, H. Alp, and S. Üstebay, “Pasif Sigara İçici Bebeklerde Serum Antioksidan Vitamin Düzeyleri ve Beslenme Tipiyle İlişkisi”, KAFKAS TIP BİL DERG, vol. 11, no. 1, pp. 16–22, 2021.
ISNAD Üstebay, Döndü Ülker et al. “Pasif Sigara İçici Bebeklerde Serum Antioksidan Vitamin Düzeyleri Ve Beslenme Tipiyle İlişkisi”. Kafkas Journal of Medical Sciences 11/1 (April 2021), 16-22.
JAMA Üstebay DÜ, Alp H, Üstebay S. Pasif Sigara İçici Bebeklerde Serum Antioksidan Vitamin Düzeyleri ve Beslenme Tipiyle İlişkisi. KAFKAS TIP BİL DERG. 2021;11:16–22.
MLA Üstebay, Döndü Ülker et al. “Pasif Sigara İçici Bebeklerde Serum Antioksidan Vitamin Düzeyleri Ve Beslenme Tipiyle İlişkisi”. Kafkas Journal of Medical Sciences, vol. 11, no. 1, 2021, pp. 16-22.
Vancouver Üstebay DÜ, Alp H, Üstebay S. Pasif Sigara İçici Bebeklerde Serum Antioksidan Vitamin Düzeyleri ve Beslenme Tipiyle İlişkisi. KAFKAS TIP BİL DERG. 2021;11(1):16-22.