Covid-19 Enfeksiyonuna Biyofiziksel Genel Bakış

Year 2021, Volume: 11 Issue: 3, 425 - 428, 01.12.2021

Denizhan Karış Damla Anbarlı Metin Feride Fulya Ercan Coşkun Aylin Köseler

Abstract

Şiddetli akut solunum sendromu koronavirüs 2 (SARS-CoV-2) enfeksiyonu, 11 Mart 2020 tarihinde DSÖ tarafından küresel bir pandemi ilan edilmiştir. Koronavirüs hastalığı (COVID-19), SARS-CoV-2’nin neden olduğu bulaşıcı hastalıktır. Damlacık yoluyla kişiden kişiye bulaşan SARS-CoV-2 enfeksiyonu, hastaların %70’inde asemptomatik olarak görülmektedir. Semptomatik hastalarda ise viral üst solunum yolu enfeksiyonundan pnömoni, sepsis, septik şok ve hatta akut solunum sıkıntısı sendromuna (ARDS) kadar değişen ciddi klinik durumlarla seyredebilmektedir. COVID-19’un epidemiyolojik ve klinik özellikleri üzerine yapılan çalışmalarda, bu hastalarının hafif veya şiddetli akut solunum yolu enfeksiyonu semptomları geliştirebileceğini gösterilmiştir. Hafif semptomları olan olgularda ateş, kuru öksürük, yorgunluk gibi üst solunum yolu semptomları gelişebilir ve anormal göğüs BT bulguları da olabilir. Farklı çalışma raporlarına göre, şiddetli semptomları olan vakalarda nefes darlığı, ishal, şiddetli pnömoni, ARDS veya çoklu organ yetmezliği gelişmekte ve ölüm oranları %4,3 ile %15 arasında değişmektedir.

Keywords

COVID-19, hemreoloji, solunum sistemi, vücut sıvıları, oksidatif stres, sedanter yaşam

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