Relation Between Obstructive Sleep Apnea Syndrome and 25-Hydroxyvitamin D Levels in Patients at High Altitude

Year 2022, Volume: 12 Issue: 3, 242 - 246, 15.12.2022

Kağan Tur Eray Atalay

Abstract

Aim: Present study’s objective is to investigate the relationship between serum 25-hydroxyvitamin D and the severity of sleep apnea at altitude. Material and Method: Fifty obstructive sleep apnea syndrome patients and 18 persons without apnea participated in this study. Apnea Hypopnea Index scores were measured with polysomnography during the night and classified as AHI<15: control, 15≥AHI<30 moderate, and AHI≥30 severe obstructive sleep apnea. In addition, the serum 25-hydroxyvitamin D levels of the patients were also measured.
Results: In the logistic regression analysis, it was found that there was an independent correlation between the apnea-hypopnea index and 25-hydroxyvitamin D (AUROC=0.658, p=0.028). We found a significant difference between the control and obstructive sleep apnea groups for 25-hydroxyvitamin D (p<0.05). A significant relationship has been found between moderate and severe obstructive sleep apnea groups for vitamin D deficiency and average vitamin D (p<0.0001).
Conclusion: We found an independent association between 25-hydroxyvitamin D and obstructive sleep apnea severity at high altitudes. An interesting point of our study is that our study has been conducted at a high altitude region with an elevation of more than 1768 meters. Therefore, effective vitamin D management may help prevent obstructive sleep apnea syndrome development, and patients’ medical status can be improved.

Keywords

25-Hydroxyvitamin D, polysomnography, obstructive sleep apnea syndrome, altitude

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