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Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature

Year 2023, Volume: 13 Issue: 1, 78 - 81, 26.04.2023

Suat Şen Fettah Acıbucu Asım Tekın Neşe Bülbül Ekin Yiğit Köroğlu

Abstract

Introduction: Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by hypercalcemia and a high or normal parathyroid hormone (PTH) level inconsistent with calcium. Complications caused by hypercalcemia or excess PTH in patients affect many systems. Therefore, early diagnosis of PHPT can help prevent complications and determine the treatment.
Method: In our study, a total of 154 patients, 122 women and 32 men, who were diagnosed with PHPT in the Endocrinology outpatient clinic were retrospectively reviewed and evaluated in the light of the literature.
Results: The mean age of the patients was 53.83±13.80 years. Detected mean values for calcium were 11.83±1.28 mg/dl, for phosphorus 2.47±0.57 mg/dl, for PTH 357.32±424.08 pg/ml, for vitamin 25OH D₃ 16.58±9.57 ng/ml, for estimated glomerular filtration rate (eGFR) was 99.03±23.84 ml/min/1.7 and for urinary calcium amount was 381.80±204.11 mg/24h. Bone mineral density (BMD) measurements were made in 64.3% (n: 99) of the patients, 38.4 % (n: 38) had osteopenia, and 42.4 % (n: 42) had osteoporosis. A history of urinary stones was found in 35.7% (n: 55) of the patients, and stone findings were found on ultrasonography in 36.1 % (n: 35). In total, 37% (n: 57) of the cases developed nephrolithiasis as a complication. In the localization study, adenoma was detected in 76.8% (n: 116) of the patients by ultrasonography, while 70.7% (n: 106) were found positive by Tc99 sestamibi scan. The lower right part was the most commonly detected adenoma localization in both imaging. In the pathology results of the operated patients, 91.5% (n: 118) were reported as adenomas. In the follow-up of the operated patients, recurrence was detected in 4.6% (n: 6).
Conclusion: Early diagnosis and treatment of PHPT are important to prevent serious complications. The absence of serious complications in the cases in our study shows the importance of early diagnosis.

Keywords

primary hyperparathyroidism hypercalcemia nephrolithiasis osteoporosis

References

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There are 15 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research Article
Authors

Suat Şen This is me

Fettah Acıbucu This is me

Asım Tekın This is me

Neşe Bülbül This is me

Ekin Yiğit Köroğlu This is me

Publication Date April 26, 2023
Published in Issue Year 2023 Volume: 13 Issue: 1

Cite

APA Şen, S., Acıbucu, F., Tekın, A., Bülbül, N., et al. (2023). Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature. Kafkas Journal of Medical Sciences, 13(1), 78-81.
AMA Şen S, Acıbucu F, Tekın A, Bülbül N, Köroğlu EY. Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature. KAFKAS TIP BİL DERG. April 2023;13(1):78-81.
Chicago Şen, Suat, Fettah Acıbucu, Asım Tekın, Neşe Bülbül, and Ekin Yiğit Köroğlu. “Review of Clinical and Laboratory Findings of Patients With Primary Hyperparathyroidism by the Literature”. Kafkas Journal of Medical Sciences 13, no. 1 (April 2023): 78-81.
EndNote Şen S, Acıbucu F, Tekın A, Bülbül N, Köroğlu EY (April 1, 2023) Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature. Kafkas Journal of Medical Sciences 13 1 78–81.
IEEE S. Şen, F. Acıbucu, A. Tekın, N. Bülbül, and E. Y. Köroğlu, “Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature”, KAFKAS TIP BİL DERG, vol. 13, no. 1, pp. 78–81, 2023.
ISNAD Şen, Suat et al. “Review of Clinical and Laboratory Findings of Patients With Primary Hyperparathyroidism by the Literature”. Kafkas Journal of Medical Sciences 13/1 (April 2023), 78-81.
JAMA Şen S, Acıbucu F, Tekın A, Bülbül N, Köroğlu EY. Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature. KAFKAS TIP BİL DERG. 2023;13:78–81.
MLA Şen, Suat et al. “Review of Clinical and Laboratory Findings of Patients With Primary Hyperparathyroidism by the Literature”. Kafkas Journal of Medical Sciences, vol. 13, no. 1, 2023, pp. 78-81.
Vancouver Şen S, Acıbucu F, Tekın A, Bülbül N, Köroğlu EY. Review of Clinical and Laboratory Findings of Patients with Primary Hyperparathyroidism by the Literature. KAFKAS TIP BİL DERG. 2023;13(1):78-81.
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