Year 2019, Volume 9 , Issue 2, Pages 323 - 334 2019-12-15

Bazı Yeni Antipirin Karbo (tiyo) amid ve 1,2,4-Triazol Türevlerinin Sentezi ve Anti-tuberküler Aktivitelerinin Karşılaştırılması
Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities

Hacer BAYRAK [1] , Yıldız UYGUN CEBECİ [2]


Bu çalışmada antipirin (4-Aminoantipirin) başlangıç maddesi olarak seçilerek karbotiyoamit ve 1,2,4-triazoltürevi bileşikler gerçekleştirilerek anti-tuberküler aktiviteleri karşılaştırılmıştır. 4-aminoantipirin sırasıyla etilbromoasetat, hidrazinhidrat ve çeşitli izo(tiyo)siyanatlar ile muamelesi sonucu bazik ortamda reaksiyonu ile halkalaşma reaksiyonu gerçekleşmesi ile yapıya ikinci bir halka olan 1,2,4-triazol halkasının ilavesi gerçekleştirildi. Sentezlenen yeni antipirin türevi bileşiklerin yapıları IR, NMR ve kütle spektrofotometresi gibi spektroskopik yöntemlerle aydınlatıldı. Sentezlenen yeni bileşikler, Gram olmayan bakteriye karşı aktivite çalışmaları gerçekleştirilmiştir. 

In this study, antipyrine (4-aminoantipyrine) was selected as the starting material and anti-tubercular activities were compared by carrying out the antipyrine nucleated carbothioamide and 1,2,4-triazole derivatives. The treatment of 4-aminoantipyrine with ethylbromoacetate, hydrazinhydrate and various iso (thio) cyanates, respectively, followed by cyclic reaction by basic reaction resulted in the addition of a second ring of 1,2,4-triazole to the structure. The structures of the synthesized new antipyrine derivatives were determined by spectroscopic methods such as IR, NMR and mass spectrophotometry. For the new compounds synthesized, activity studies were performed against non-Gram bacteria.
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Primary Language en
Subjects Basic Sciences
Journal Section Articles
Authors

Orcid: 0000-0001-5843-8716
Author: Hacer BAYRAK (Primary Author)
Institution: KARADENİZ TEKNİK ÜNİVERSİTESİ, MAÇKA MESLEK YÜKSEKOKULU
Country: Turkey


Orcid: 0000-0001-7949-0329
Author: Yıldız UYGUN CEBECİ
Institution: KARADENİZ TEKNİK ÜNİVERSİTESİ
Country: Turkey


Supporting Institution Karadeniz Teknik Üniversitesi Bilimsel Araştırma Projesi (KTÜ-BAP)
Project Number 5289
Thanks This work was supported by the Scientific research project of Karadeniz Technical University (KTU-BAP) [grant numbers 5289]. The author also thanks to Prof. Şengül Alpay Karaoğlu for the antitubercular activity studies.
Dates

Publication Date : December 15, 2019

Bibtex @research article { kfbd620635, journal = {Karadeniz Fen Bilimleri Dergisi}, issn = {1309-4726}, eissn = {2564-7377}, address = {Giresun Üniversitesi Fen Bilimleri Enstitüsü Güre Yerleşkesi 28200 / Giresun}, publisher = {Giresun University}, year = {2019}, volume = {9}, pages = {323 - 334}, doi = {10.31466/kfbd.620635}, title = {Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities}, key = {cite}, author = {BAYRAK, Hacer and UYGUN CEBECİ, Yıldız} }
APA BAYRAK, H , UYGUN CEBECİ, Y . (2019). Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities. Karadeniz Fen Bilimleri Dergisi , 9 (2) , 323-334 . DOI: 10.31466/kfbd.620635
MLA BAYRAK, H , UYGUN CEBECİ, Y . "Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities". Karadeniz Fen Bilimleri Dergisi 9 (2019 ): 323-334 <https://dergipark.org.tr/en/pub/kfbd/issue/50311/620635>
Chicago BAYRAK, H , UYGUN CEBECİ, Y . "Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities". Karadeniz Fen Bilimleri Dergisi 9 (2019 ): 323-334
RIS TY - JOUR T1 - Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities AU - Hacer BAYRAK , Yıldız UYGUN CEBECİ Y1 - 2019 PY - 2019 N1 - doi: 10.31466/kfbd.620635 DO - 10.31466/kfbd.620635 T2 - Karadeniz Fen Bilimleri Dergisi JF - Journal JO - JOR SP - 323 EP - 334 VL - 9 IS - 2 SN - 1309-4726-2564-7377 M3 - doi: 10.31466/kfbd.620635 UR - https://doi.org/10.31466/kfbd.620635 Y2 - 2019 ER -
EndNote %0 Karadeniz Fen Bilimleri Dergisi Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities %A Hacer BAYRAK , Yıldız UYGUN CEBECİ %T Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities %D 2019 %J Karadeniz Fen Bilimleri Dergisi %P 1309-4726-2564-7377 %V 9 %N 2 %R doi: 10.31466/kfbd.620635 %U 10.31466/kfbd.620635
ISNAD BAYRAK, Hacer , UYGUN CEBECİ, Yıldız . "Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities". Karadeniz Fen Bilimleri Dergisi 9 / 2 (December 2019): 323-334 . https://doi.org/10.31466/kfbd.620635
AMA BAYRAK H , UYGUN CEBECİ Y . Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities. KFBD. 2019; 9(2): 323-334.
Vancouver BAYRAK H , UYGUN CEBECİ Y . Synthesis of Some New Kind of Antipyrine Carbo(thio)amide and 1,2,4-Triazole Derivatives and Comparing Their Anti-tubercular Activities. Karadeniz Fen Bilimleri Dergisi. 2019; 9(2): 334-323.