Plateletkrit ve Trombosit Dağılım Genişliği Koroner Arter Ektazisinin Bağımsız Öngördürücüsüdür

Year 2016, Volume: 19 Issue: 3, 173 - 178, 01.12.2016

Hikmet Hamur , Kamuran Kalkan Hakan Duman Murtaza Emre Durakoğlugil Zafer Küçüksu Sinan İnci Erkan Yıldırım

Abstract

Giriş:
Koroner arter ektazisi (KAE), koroner arterlerin
anormal genişlemesi ile karakterize edilir. Ortalama trombosit hacmi (OTH),
trombosit dağılım genişliği (TDG), plateletkrit (PKT) dahil olmak üzere
trombosit hacmi endeksleri ve trombosit sayısı trombosit aktivasyonunun
göstergeleridir. Bu çalışmada KAE’li hastalarda trombosit hacmi endeksleri
incelendi.

Hastalar
ve Yöntem: Çalışmaya, izole KAE’si olan
51 (38 erkek; ortalama yaş: 52 + 9.9 yıl) hasta ve koroner arterleri normal
olan 50 (39 erkek; ortalama yaş: 54 + 11.3 yıl) sağlıklı birey dahil edildi.
Başvuruda trombosit hacmi endeksleri otomatik tam kan sayımı parçası olarak
ölçüldü.

Bulgular:
Trombosit sayımı, OTH, PKT ve TDG, KAE grubunda
kontrol grubuna göre daha yüksekti (p< 0.05). Çok değişkenli lojistik
regresyon analizinde, TDG (Odds oranı: 0.22, %95 güven aralığı: 0.06-0.73, p=
0.013) ve PKT’nin (Odds oranı: 3.41, %95 güven aralığı: 1.66-6.98, p≤ 0.001)
KAE’nin bağımsız öngördürücüleri olduğu gösterildi.

Sonuç:
Bu çalışma, PKT ve TDG’nin KAE’nin bağımsız
belirleyicileri olduğunu göstermektedir.

Keywords

Koroner arter ektazisi, koroner arter hastalığı, ortalama trombosit hacmi, trombosit dağılım genişliği

Plateletcrit and Platelet Distribution Width as Independent Predictors of Coronary Artery Ectasia

Abstract

Introduction:
Coronary artery ectasia (CAE) is characterised by
an abnormal dilatation of the coronary arteries. Platelet volume indices,
including the mean platelet volume (MPV), platelet distribution width (PDW),
plateletcrit (PCT) and platelet count, are indicators of platelet activation.
In this study, we investigated platelet volume indices in patients with CAE.

Patients
and Methods: The study group included 51 patients (38 men;
mean age: 52 ± 9.9 years) with isolated CAE and 50 individuals with normal
coronary arteries (39 men; mean age: 54 ± 11.3 years). Admission platelet
volume indices were measured as part of the automated complete blood count.

Results:
Platelet count, MPV, PCT and PDW were higher in CAE
than in the control group (p< 0.05). Multivariate analysis revealed PDW
(odds ratio: 0.22, 95% confidence interval: 0.06-0.73, p= 0.013) and PCT (odds
ratio: 3.41, 95% confidence interval: 1.66-6.98, p≤ 0.001) as independent
predictors of CAE.

Conclusion:
This study demonstrates that PCT and PDW are
independent predictors of CAE.

Keywords

Coronary artery ectasia, coronary artery disease, mean platelet volume, platelet distribution width

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