Purpose of the descriptive-cross sectional epidemiological research is to determine the health literacy level of textile factory employees and to determine the related factors. The sample size was calculated as 360 people, with a mean of 29, a standard deviation of 3, and a type 1 error level of 5%, with a 95% confidence interval. All those who accepted the research were included in the research. The data collection tool of the research was a questionnaire consisting of 70 questions. The health literacy level of the participants was evaluated with the Turkish Health Literacy Scale (TSOY-32). Statistical Package for the Social Sciences (SPSS) version 18.0 was used for statistical analysis of the data. p<0.05 was considered significant. 260 people participated in the research. 21.2% of the participants had inadequate, 35.2% problematic-limited, 28.8% adequate and 14.8% excellent health literacy levels. Having a high school or higher education 1.96 times (CI=1.05-3.63, p=0.033), not having difficulty understanding occupational health and safety instructions 3.10 times (CI=1.35-7.07) , p=0.007) increased the level of adequate-perfect health literacy. Almost half of the employees have insufficient or problematic-limited level of health literacy. Education level is an important determinant of health literacy level. The health literacy level of those who have difficulty in understanding the occupational health and safety instructions is also low.