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Venlafaxin Zehirlenmesinde Serotonin Sendromu, Rabdomyoliz ve Kardiyak Toksisite:Olgu Sunumu

Year 2012, Volume: 13 Issue: 3, 173 - 175, 01.12.2012

Elif DOĞAN Bakı

Abstract

Keywords

-

References

  • Holliday SM, Benfield P. Venlafaxine. A review of its pharmacology and therapeutic potential in depres- sion. Drugs 1995;4:280—82.
  • Johnson EM, Whyte E, Mulsant BH, Pollock BG, Weber E, Begley AE, Reynolds CF. Cardiovascular changes associated with venlafaxine in the treatment of late-life depression. Am J Geriatr Psychiatry 2006;14:796—802.
  • Buckley NA, McManus PR. Fatal toxicity of seroto- ninergic and other antidepressant drugs: analysis of United Kingdom mortality data. BMJ 2002;325:1332— 3.
  • Whyte IM, Dawson AH, Buckley NA. Relative toxici- ty of venlafaxine and selective serotonin reuptake inhibitors in overdose compared to tricyclic antide- pressants. QJM 2003;96:369—74.
  • Hojer J, Hulting J, Salmonson H. Fatal cardiotoxicity induced by venlafaxine overdosage. Clin Toxicol (Phi- la) 2008;46:336—7.
  • Kelly CA, Dhaun N, Laing WJ, et al. Comparative toxicity of citalopram and the newer antidepressants after overdose. J Toxicol Clin Toxico. 2004;42(1):67- 71.
  • White CM, Gailey RA, Levin GM, et al. Seizure re- sulting from a venlafaxine overdose. Ann Pharma- cother 1997;31(2):178-80.
  • Boyer EW, Shannon MPH: The Serotonin Syn- drome. N EnglJ Med 2005;352:1112-20.
  • Sternbach H. The serotonin syndrome. Am J Psy- chiatry 1991;148:705-13.
  • Wi|son AD, Howell C, Waring WS. Venlafaxine ingestions is associated with rhabdomyolosis in- adults.TheJ of Toxicol Sci 2007;32(1):97-101.
  • Howell C , Wilson AD, Waring WS. Cardiovasculer toxicity due to venlafaxine poisoning in adults: a re- view of 235 cobsecutive cases. Br J Clin Pharmocol 2007;64:192-7.
  • Mazur JE, doty JD Kyrygiel AS. Pharmocotherapy 2003;23(12):1668-72.
  • Combes A, Peytavin G, Theron D. Conduction disturbances associated with venlafaxine. Ann Intern Med. 2001;134:166—7.
  • Kocatepe Tıp Dergisi, Cilt 13 No:3, Eylül 2012

Venlafaxin Zehirlenmesinde Serotonin Sendromu, Rabdomyoliz ve Kardiyak Toksisite: Olgu Sunumu

Year 2012, Volume: 13 Issue: 3, 173 - 175, 01.12.2012

Elif DOĞAN Bakı

Abstract

Selektif antidepresan ajanların birinci sıra tedavi kullanımları giderek artmaktadır. Biz rabdomyoliz, patolojik Q’lar içeren kardiyak toksisite ve seratonin sendromlu 6gr venlafaxine zehirlenmesini sunuyoruz.Hasta yoğun bakım ünitemize geldiğinde hemodinamik olarak stabildi fakat kas rijiditesi, hiperrefleksisi, pupil genişlemesi ve yükselmiş kreatinin kinaz (CK) seviyesi mevcuttu. Literatürde yüksek doz aşımlarında venlafaksinin kardiyak toksisite ve ölüme neden olduğu görülmektedir. Doktorlar venlafaxine zehirlenmelerinde rabdomyoliz ve kardiyak toksisite açısından dikkatli olmalıdırlar

Keywords

rabdomyoliz serotonin sendromu venlafaxin

References

  • Holliday SM, Benfield P. Venlafaxine. A review of its pharmacology and therapeutic potential in depres- sion. Drugs 1995;4:280—82.
  • Johnson EM, Whyte E, Mulsant BH, Pollock BG, Weber E, Begley AE, Reynolds CF. Cardiovascular changes associated with venlafaxine in the treatment of late-life depression. Am J Geriatr Psychiatry 2006;14:796—802.
  • Buckley NA, McManus PR. Fatal toxicity of seroto- ninergic and other antidepressant drugs: analysis of United Kingdom mortality data. BMJ 2002;325:1332— 3.
  • Whyte IM, Dawson AH, Buckley NA. Relative toxici- ty of venlafaxine and selective serotonin reuptake inhibitors in overdose compared to tricyclic antide- pressants. QJM 2003;96:369—74.
  • Hojer J, Hulting J, Salmonson H. Fatal cardiotoxicity induced by venlafaxine overdosage. Clin Toxicol (Phi- la) 2008;46:336—7.
  • Kelly CA, Dhaun N, Laing WJ, et al. Comparative toxicity of citalopram and the newer antidepressants after overdose. J Toxicol Clin Toxico. 2004;42(1):67- 71.
  • White CM, Gailey RA, Levin GM, et al. Seizure re- sulting from a venlafaxine overdose. Ann Pharma- cother 1997;31(2):178-80.
  • Boyer EW, Shannon MPH: The Serotonin Syn- drome. N EnglJ Med 2005;352:1112-20.
  • Sternbach H. The serotonin syndrome. Am J Psy- chiatry 1991;148:705-13.
  • Wi|son AD, Howell C, Waring WS. Venlafaxine ingestions is associated with rhabdomyolosis in- adults.TheJ of Toxicol Sci 2007;32(1):97-101.
  • Howell C , Wilson AD, Waring WS. Cardiovasculer toxicity due to venlafaxine poisoning in adults: a re- view of 235 cobsecutive cases. Br J Clin Pharmocol 2007;64:192-7.
  • Mazur JE, doty JD Kyrygiel AS. Pharmocotherapy 2003;23(12):1668-72.
  • Combes A, Peytavin G, Theron D. Conduction disturbances associated with venlafaxine. Ann Intern Med. 2001;134:166—7.
  • Kocatepe Tıp Dergisi, Cilt 13 No:3, Eylül 2012
There are 14 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Elif DOĞAN Bakı This is me

Publication Date December 1, 2012
Published in Issue Year 2012 Volume: 13 Issue: 3

Cite

APA Bakı, E. D. (2012). Venlafaxin Zehirlenmesinde Serotonin Sendromu, Rabdomyoliz ve Kardiyak Toksisite: Olgu Sunumu. Kocatepe Tıp Dergisi, 13(3), 173-175. https://doi.org/10.18229/ktd.89854
AMA Bakı ED. Venlafaxin Zehirlenmesinde Serotonin Sendromu, Rabdomyoliz ve Kardiyak Toksisite: Olgu Sunumu. KTD. December 2012;13(3):173-175. doi:10.18229/ktd.89854
Chicago Bakı, Elif DOĞAN. “Venlafaxin Zehirlenmesinde Serotonin Sendromu, Rabdomyoliz Ve Kardiyak Toksisite: Olgu Sunumu”. Kocatepe Tıp Dergisi 13, no. 3 (December 2012): 173-75. https://doi.org/10.18229/ktd.89854.
EndNote Bakı ED (December 1, 2012) Venlafaxin Zehirlenmesinde Serotonin Sendromu, Rabdomyoliz ve Kardiyak Toksisite: Olgu Sunumu. Kocatepe Tıp Dergisi 13 3 173–175.
IEEE E. D. Bakı, “Venlafaxin Zehirlenmesinde Serotonin Sendromu, Rabdomyoliz ve Kardiyak Toksisite: Olgu Sunumu”, KTD, vol. 13, no. 3, pp. 173–175, 2012, doi: 10.18229/ktd.89854.
ISNAD Bakı, Elif DOĞAN. “Venlafaxin Zehirlenmesinde Serotonin Sendromu, Rabdomyoliz Ve Kardiyak Toksisite: Olgu Sunumu”. Kocatepe Tıp Dergisi 13/3 (December 2012), 173-175. https://doi.org/10.18229/ktd.89854.
JAMA Bakı ED. Venlafaxin Zehirlenmesinde Serotonin Sendromu, Rabdomyoliz ve Kardiyak Toksisite: Olgu Sunumu. KTD. 2012;13:173–175.
MLA Bakı, Elif DOĞAN. “Venlafaxin Zehirlenmesinde Serotonin Sendromu, Rabdomyoliz Ve Kardiyak Toksisite: Olgu Sunumu”. Kocatepe Tıp Dergisi, vol. 13, no. 3, 2012, pp. 173-5, doi:10.18229/ktd.89854.
Vancouver Bakı ED. Venlafaxin Zehirlenmesinde Serotonin Sendromu, Rabdomyoliz ve Kardiyak Toksisite: Olgu Sunumu. KTD. 2012;13(3):173-5.

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