Year 2007,
Volume: 8 Issue: 1, - , 01.04.2007
Abstract
Keywords
References
- Chatziantoniou VD. Telomerase: Biological function
- and potential role in cancer management. Patltol On
- col Res. 2001; 7: 161-170.
- Colgin ML. Reddel RR. Telomere maintenance
- mechanisms and cellular immortalization, Curr Opin
- Genet Dev, 1999: 9: 97-103.
- Lingner J. Cech TR. Telomerase and chromosome
- end maintenance. Current Opinion in Genetics & De
- velopment, 1998; 8:226-232.
- Morii K. Tanaka R. Onda K. Tsumanuma [. Yoshi
- mura J. Expression of telomerase RNA. telomerase
- activity. and telomere length in human gliomas. Bio
- chem Biophys Res Commun. 1997; 239: 830-834.
- Shay JW, Wright WE. Telomerase activity in human
- cancer. Curr Opin Oncol. 1997; 8: 66-71.
- Fukushima T. Yoshino A. Katayama Y. Kusama K,
- Moro 1. Prediction of‘clinical course of diffusely inŞl
- trating astrocytomas from telomerase expression and
- quantitated activity level. Cancer Lett. 2002; 187: 191—198.
- Harada K. Kurisi K. Tahara H, Ide T. Tahara E. Te
- lomerase acticity in primary and secondary glioblas
- tomas multiforme as a novel molecular tumor marker.
- J Neurosurg. 2000'. 93: 618—625.
- Huang F. Kanno H. Yamamoton 1. Lin Y. Kuboto Y.
- Correlation ofclinical features and telomerase activ
- ity in human gliomas. J Neuro Oncol. 1999; 43: 137- 142.
- Kleinschmith-demaster BK. Evans LC. Bobak JB.
- Lopez-Uribe D. Hopper D. Shroyer AL. Shroyer KR.
- Quantitative telomerase expression in glioblastomas
- shows regional variation and down-regulation with
- therapy but no correlation with patiant outcome. Hum
- Pathol, 2000: 31: 905-913. . Shervington A. Cruickshanks N, Wright H. Atkinson—
- Dell R. Lea R. Roberts G. Shervington L: Glioma:
- 3-linked glycoprotein sialylation are increased in malignant gliomas. Brain Res. 1997; 755: 175-179.
- Marth E. Flaschka G, Stiegler S. Mose J. Sialic acid
- as a marker for differentiation between benign and
- malignant intracranial tumors. Clin Chem Acta, 1988: 176: 251-257. . Sonmez H. Kokoglu H, Suer S. Ozyurt E. Fibronectin
- and sialic acid levels in human meningiomas and
- gliomas. Cancer Lett. 1995; 90(2): 119-122. . Suzuki M. Suzuki M, Nakayama J. Suziki A. Angata
- K. Chen S. Sakai K. Hagihara K. Yamaguchi Y. Fu—
- The Progression qf'Te/omerrrse Activity Am] Sia/ic Acid Levelx in Rat Glioma Cell Lines /
- Siam Glioma Hücre Dizilerinde Teloıızera: Aktivitesi ve Simli/c A.s'it
- kuda M. Polysialic acid facilitates tumor invasion by
- glioma cells. Glycobiology. 2005: 15: 887-894. . Kim NW. Piatyszek MA. Prowsc KR. Harley CB.
- West MD. Ho PL, Coviello GM. Wright WE.
- Weinrich SL. Shay CW: Specific association of hu—
- man telomerase activity with cell and cancer. Science
- : 2011-2015. 1994. . Shay JW. Bacehetti S. A survey oftelomerase activ—
- ity in human cancer. Eur .1 Cancer. 1997 : 33(5): 787- 791. . Wynford—Thomas D. Cellular senescence and cancer.
- Jl‘athol. 1999: 187: 100-111. . Inoue H. Tsuchida A. Kawasaki Y. Fujimato Y. Ya
- masaki S, Kajiyama G. Preoperative diagnosis of in
- traductal papillary-mucinous tumors ol' the pancreas
- with attention to telomcrase activity. Cancer. 2000: 91: 35-41. . Hiyama E, Saeki T, Hiyama K, Takashima S. Shay
- JW. Matsuura Y. Yokoyama T. Telomcrase activity
- as a marker of breast carcinoma in line-needle aspi
- rated samples. Cancer. 2000; 90: 235-238. . Kyo S. Kanaya T. lshikava 1'1. Ueno H, Inoue M. Te
- lomerase activity in gynecological tumors. Clin Can
- cer Res. 1996: 2: 2023-2028. . Murakami J. Nagai N. Ohama K, Tahara H. Ide T.
- Tclomerase activity in ovarian tumors. Cancer. 1997: 80: 1085-92. . Tomoda R. Seto M. Tsumuki H. lida K. Yamazaki T.
- Sonoda J. Matsumine A, Uchida A. Telomerase activ- ity and human telomerase reverse transcriptase mRNA expression are correlated with clinical aggres— siveness in soft tissue tumors. Cancer. 2002: 95(5): 1 127-1133. . Victor M. Winter 5. Groscurth P. Naumann U. Welter
- M. On the signiŞcance of telomerase activity in hu
- man malignant glioma cells. Eur J Pharmacol. 2000:
- (1): 27-37. . Shen ZY. Xu LY. Chen MH. Shen J. Cai WJ. Zeng
- Y. Progressive transformation of immortalized euso
- phageal epithelial cells. World J Gastroenterol. 2002:
- (6): 976-981. . Canoruc N. Canoruc F. Ozden T. Sen C. Degenekin
- H. Goral V. Ayyildiz O. Gastrointestinal sistem kan—
- serlerinde sialik asit ve alkalen l'osfatazm serum dü
- zeyleri ve tanıdaki önemleri. Gastroenteroloji. 1993:
- (4): 656-660. . ()ktem F, Toprak M. Yazıcılar 0. Öz F. Ada M.
- Larinks kanserlerinde sialik asit değişimleri. Turk
- Otolarengoloji Arsivi. 1999; 37(3—4): 98-104. . Bhatavdekar JM. Patel DD. Vora HH. Balaı' DB.
- Squamous cell carcinoma antigen and protein-bound
- sialic acid in the management of head and neck can
- cer. Int J Biol Markers. 1991: 6 (4): 237-240. . Uslu E. Belee A. Seymen P, Kökoğlu E. Kolorektal
- kanserde metastazın serum total siyalik asit düzeyleri
- üzerine etkisi. Cerrahpasa J Med. 2000: 31(4): 231- 234.
- Kor'atepe Tip Dergiyi, Cilt N Na: I , Out/r 2007.
Year 2007,
Volume: 8 Issue: 1, - , 01.04.2007
Abstract
Amaç: Teloıneraz kanser hücrelerinin ölümsüzlüğünde önemli bir rol oynar. Telomeraz. telomeraz RNA'sı ve tclomeraz revers transkriptazdan oluşur. Siyalik asit. hücresel membranı güçlendirir vc hücreler arası aktivitede büyük rol oynar. Polisiyalik asit zincirleri. nöronal hücre adezyon molekülünün adeziv fonksiyonunu değiştirir. 'l‘clomeraz aktivitesi ve siyalik asit düzeyleri tümör belirleyicisi olarak kullanılabilir. Gereç ve Yöntem: C6 sıçan glioma hücre dizisinden ard arda yapılan 3.. 6.. 9., 12. ve 15. pasajların ekstraktlarında. telomeraz aktivitesi ve siyalik asit düzeyleri incelendi. Telomeraz aktivitesini belirleınek için. TRAP TeloTAGGG Telomerase PCR ELISA plus. siyalik asit düzeylerini belirlemek için. Sialic acid quantiŞcation kiti, kullanıldı. Bulgulur: 'l'elomeraz aktivitesi C6 hücre dizisinin pasajlarmda. dalgalanmalar şeklinde bir artış gösterdi. Telomeraz RNA"sı ve teloıneraz revers transkriptazın ekspresyonları tüm pasajlarda pozitif olarak izlendi. Siyalik asit düzeyleri, ilk pasajdan itibaren son pasaja doğru düzenli bir aıtış gösterdi. Sonuç: C6 hücre dizilerinin ilerleyen pasajlarında siyalik asitin düzenli bir şekilde giderek artması, telomeraz aktivitesindeki artışın ise düzensiz olması. gliomalarm klinik ve biyolojik davranışlarının belirlenmesinde, telomeraz aktivitesinden ziyade. siyalik asitin daha güvenilir biyolojik prognostik Faktör olabileceğini düşündürmektedir
References
- Chatziantoniou VD. Telomerase: Biological function
- and potential role in cancer management. Patltol On
- col Res. 2001; 7: 161-170.
- Colgin ML. Reddel RR. Telomere maintenance
- mechanisms and cellular immortalization, Curr Opin
- Genet Dev, 1999: 9: 97-103.
- Lingner J. Cech TR. Telomerase and chromosome
- end maintenance. Current Opinion in Genetics & De
- velopment, 1998; 8:226-232.
- Morii K. Tanaka R. Onda K. Tsumanuma [. Yoshi
- mura J. Expression of telomerase RNA. telomerase
- activity. and telomere length in human gliomas. Bio
- chem Biophys Res Commun. 1997; 239: 830-834.
- Shay JW, Wright WE. Telomerase activity in human
- cancer. Curr Opin Oncol. 1997; 8: 66-71.
- Fukushima T. Yoshino A. Katayama Y. Kusama K,
- Moro 1. Prediction of‘clinical course of diffusely inŞl
- trating astrocytomas from telomerase expression and
- quantitated activity level. Cancer Lett. 2002; 187: 191—198.
- Harada K. Kurisi K. Tahara H, Ide T. Tahara E. Te
- lomerase acticity in primary and secondary glioblas
- tomas multiforme as a novel molecular tumor marker.
- J Neurosurg. 2000'. 93: 618—625.
- Huang F. Kanno H. Yamamoton 1. Lin Y. Kuboto Y.
- Correlation ofclinical features and telomerase activ
- ity in human gliomas. J Neuro Oncol. 1999; 43: 137- 142.
- Kleinschmith-demaster BK. Evans LC. Bobak JB.
- Lopez-Uribe D. Hopper D. Shroyer AL. Shroyer KR.
- Quantitative telomerase expression in glioblastomas
- shows regional variation and down-regulation with
- therapy but no correlation with patiant outcome. Hum
- Pathol, 2000: 31: 905-913. . Shervington A. Cruickshanks N, Wright H. Atkinson—
- Dell R. Lea R. Roberts G. Shervington L: Glioma:
- 3-linked glycoprotein sialylation are increased in malignant gliomas. Brain Res. 1997; 755: 175-179.
- Marth E. Flaschka G, Stiegler S. Mose J. Sialic acid
- as a marker for differentiation between benign and
- malignant intracranial tumors. Clin Chem Acta, 1988: 176: 251-257. . Sonmez H. Kokoglu H, Suer S. Ozyurt E. Fibronectin
- and sialic acid levels in human meningiomas and
- gliomas. Cancer Lett. 1995; 90(2): 119-122. . Suzuki M. Suzuki M, Nakayama J. Suziki A. Angata
- K. Chen S. Sakai K. Hagihara K. Yamaguchi Y. Fu—
- The Progression qf'Te/omerrrse Activity Am] Sia/ic Acid Levelx in Rat Glioma Cell Lines /
- Siam Glioma Hücre Dizilerinde Teloıızera: Aktivitesi ve Simli/c A.s'it
- kuda M. Polysialic acid facilitates tumor invasion by
- glioma cells. Glycobiology. 2005: 15: 887-894. . Kim NW. Piatyszek MA. Prowsc KR. Harley CB.
- West MD. Ho PL, Coviello GM. Wright WE.
- Weinrich SL. Shay CW: Specific association of hu—
- man telomerase activity with cell and cancer. Science
- : 2011-2015. 1994. . Shay JW. Bacehetti S. A survey oftelomerase activ—
- ity in human cancer. Eur .1 Cancer. 1997 : 33(5): 787- 791. . Wynford—Thomas D. Cellular senescence and cancer.
- Jl‘athol. 1999: 187: 100-111. . Inoue H. Tsuchida A. Kawasaki Y. Fujimato Y. Ya
- masaki S, Kajiyama G. Preoperative diagnosis of in
- traductal papillary-mucinous tumors ol' the pancreas
- with attention to telomcrase activity. Cancer. 2000: 91: 35-41. . Hiyama E, Saeki T, Hiyama K, Takashima S. Shay
- JW. Matsuura Y. Yokoyama T. Telomcrase activity
- as a marker of breast carcinoma in line-needle aspi
- rated samples. Cancer. 2000; 90: 235-238. . Kyo S. Kanaya T. lshikava 1'1. Ueno H, Inoue M. Te
- lomerase activity in gynecological tumors. Clin Can
- cer Res. 1996: 2: 2023-2028. . Murakami J. Nagai N. Ohama K, Tahara H. Ide T.
- Tclomerase activity in ovarian tumors. Cancer. 1997: 80: 1085-92. . Tomoda R. Seto M. Tsumuki H. lida K. Yamazaki T.
- Sonoda J. Matsumine A, Uchida A. Telomerase activ- ity and human telomerase reverse transcriptase mRNA expression are correlated with clinical aggres— siveness in soft tissue tumors. Cancer. 2002: 95(5): 1 127-1133. . Victor M. Winter 5. Groscurth P. Naumann U. Welter
- M. On the signiŞcance of telomerase activity in hu
- man malignant glioma cells. Eur J Pharmacol. 2000:
- (1): 27-37. . Shen ZY. Xu LY. Chen MH. Shen J. Cai WJ. Zeng
- Y. Progressive transformation of immortalized euso
- phageal epithelial cells. World J Gastroenterol. 2002:
- (6): 976-981. . Canoruc N. Canoruc F. Ozden T. Sen C. Degenekin
- H. Goral V. Ayyildiz O. Gastrointestinal sistem kan—
- serlerinde sialik asit ve alkalen l'osfatazm serum dü
- zeyleri ve tanıdaki önemleri. Gastroenteroloji. 1993:
- (4): 656-660. . ()ktem F, Toprak M. Yazıcılar 0. Öz F. Ada M.
- Larinks kanserlerinde sialik asit değişimleri. Turk
- Otolarengoloji Arsivi. 1999; 37(3—4): 98-104. . Bhatavdekar JM. Patel DD. Vora HH. Balaı' DB.
- Squamous cell carcinoma antigen and protein-bound
- sialic acid in the management of head and neck can
- cer. Int J Biol Markers. 1991: 6 (4): 237-240. . Uslu E. Belee A. Seymen P, Kökoğlu E. Kolorektal
- kanserde metastazın serum total siyalik asit düzeyleri
- üzerine etkisi. Cerrahpasa J Med. 2000: 31(4): 231- 234.
- Kor'atepe Tip Dergiyi, Cilt N Na: I , Out/r 2007.
There are 78 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | April 1, 2007 |
| Published in Issue | Year 2007 Volume: 8 Issue: 1 |
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