Evaluation of the Effect of Biomarker Levels Associated with Disease Severity on Mortality in COVID-19 Patients in the Gaziantep Region of Turkey

Year 2023, Volume: 26 Issue: 6, 1239 - 1245, 31.12.2023

Hüseyin Gürbüz Sinem Bayrakçı Onur Bayrakçı Hülya Çiçek

https://doi.org/10.18016/ksutarimdoga.vi.1189752

Abstract

This study aimed to investigate the effect of clinical and some specific laboratory parameters on the prognosis and mortality of critically ill COVID-19 patients who need to be followed in the intensive care unit (ICU). This is a retrospective cohort study. A total of 180 patients treated in the ICU were included in the study. The data of clinical and levels of D-dimer, cardiac troponin I (cTnI), Ferritin, and CK-MB were researched. The multivariate and univariate logistic regression models were employed to investigate the risk factors affiliated with in-hospital death. There was a significant difference in mortality between women and men (p=0.002). Hypertension was the most common comorbid disease, mortality was detected to be significantly greater in patients over 65 years of age. The serum D-dimer, cTnI, CK-MB, and ferritin levels were found to be higher in patients at risk. In the multivariate logistic regression model, we detected that ferritin above 300 μg/l (p=0.05) alongside cancer was associated with mortality. This study showed that advanced age is an important risk factor as well as the mortality of patients with cancer –especially those with a ferritin value above 300 μg/l and patients with a high cTnI value.

Keywords

COVID-19, D-Dimer, CK-MB, Ferritin, Cardiac troponin-I

Türkiye'nin Gaziantep Bölgesinde COVID-19 Hastalarında Hastalık Şiddetiyle İlişkili Biyobelirteç Düzeylerinin Mortalite Üzerine Etkisinin Değerlendirilmesi

Abstract

Bu çalışma, yoğun bakım ünitesinde (YBÜ) takip edilmesi gereken kritik COVID-19 hastalarının prognoz ve mortalitesi üzerine klinik ve bazı özellikli laboratuvar parametrelerinin etkisini araştırmayı amaçlamıştır. Bu retrospektif bir kohort çalışmasıdır. Yoğun bakımda tedavi edilen toplam 180 hasta çalışmaya dahil edildi. D-dimer, kardiyak troponin I (cTnI), Ferritin ve CK-MB klinik verileri ve düzeyleri araştırıldı. Hastane içi ölümle ilişkili risk faktörlerini araştırmak için çok değişkenli ve tek değişkenli lojistik regresyon modelleri kullanıldı. Kadınlar ve erkekler arasında mortalite açısından anlamlı fark vardı (p=0,002). Hipertansiyon en sık görülen komorbid hastalıktı, mortalite 65 yaş üstü hastalarda anlamlı olarak daha yüksek saptandı. Risk altındaki hastalarda serum D-dimer, cTnI, CK-MB ve ferritin düzeyleri daha yüksek bulundu. Çok değişkenli lojistik regresyon modelinde, kanserle birlikte 300 μg/l'nin (p=0.05) üzerindeki ferritinin mortalite ile ilişkili olduğunu saptandı. Bu çalışma kanserli hastalarda, özellikle ferritin değeri 300 μg/l'nin üzerinde olanlarda ve cTnI değeri yüksek olan hastalarda, ileri yaşın mortalitesi kadar önemli bir risk faktörü olduğunu göstermiştir. Serum D-dimer, cTnI, CK-MB ve ferritin düzeyleri yüksek olan hastalarda mortalite anlamlı olarak daha yüksekti.

Keywords

COVID-19, D-Dimer, CK-MB, Ferritin, Kardiyak troponin-I

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