Kahramanmaraş Bölgesine Ait Serum Örneklerinde Ölçülen Tümör Belirteçlerinin Referans Değerlerinin Belirlenmesi

Yıl 2019, Cilt: 14 Sayı: 3, 124 - 134, 15.11.2019

Muhammed Mehdi Üremiş , Nuray Üremiş

https://doi.org/10.17517/ksutfd.561639

Öz

Amaç: Referans aralıkları hastalığın teşhisi, izlenmesi ve tedavisi için oldukça önemlidir. Bununla birlikte, referans aralıkları yaşa, cinsiyete, coğrafi bölgeye, diyet durumuna ve diğer faktörlere göre değişebilir. Bu çalışmanın amacı, Kahramanmaraş Bölgesine ait Alfa-fetoprotein (AFP), Karbonhidrat Antijen 15-3 (CA 15.3), Karbonhidrat Antijen 19.9 (CA 19.9), Karbonhidrat Antijen 125 (CA 125), Karsinoembriyonik Antijen (CEA), Prostat Spesifik Antijen (PSA), serbest PSA (fPSA) ve tiroglobulin (TG) için referans aralıklarını belirlemektir. Gereç ve Yöntem: Toplamda 64,687 kişilik veriden 21,190 kişinin seçilmesiyle Klinik Biyokimya Laboratuvarından türetilen veriler kullanılmıştır. Tüm parametreler için referans aralıkları hesaplanırken indirect ve parametrik olmayan yüzde tahmin yöntemi kullanılmıştır. Bulgular: Çalışılan parametreler için aşağıdaki gibi alt ve üst sınırlar belirlenmiştir - AFP: 0.52, 3.76 IU/ml; CA 15.3: 5.0, 37.60 IU/ml; CA 19.9: 2.46, 29.5 IU/ml; CA 125: 2.89, 22.7 IU/ml; CEA: 0.11, 3.67 ng/ml; fPSA: 0.02, 0.75 ng/ml; PSA: 0.14, 2.31 ng/ml; and TG: 0.34, 30.13 ng/ml.Sonuç: Bu çalışma, üretici firmalar tarafından incelenen parametreler için alıntı yapılan referans aralıklarının, popülasyonumuza özgü referans aralıklarıyla tam olarak örtüşmediğini göstermektedir. Bölgesel referans aralıkları belirlenerek tarama testlerinin verimliliğini artırabilir. 

Anahtar Kelimeler

referans aralık, tümör belirteçleri, kahramanmaraş

Determination of Reference Interval of Tumour Markers in Kahramanmaraş Region, Turkey

Öz

Objectives:  Reference intervals are important for disease diagnosis, monitoring and treatment. However, reference intervals may vary by age, gender, geographical location, dietary status and other factors.The aim of this study is to determine the reference intervals for alpha-fetoprotein
(AFP), CarbohydrateAntigen 15-3 (CA 15.3), Carbohydrate Antigen 19.9 (CA 19.9),
Carbohydrate Antigen 125 (CA 125), Carcinoembryonic
Antigen (CEA), Prostate Specific Antigen (PSA), free PSA (fPSA), and
thyroglobulin (TG) in Kahramanmaraş Region, Turkey.

Material and Methods: Data derived from 21,190 individuals in 64,687 were
obtained from the Clinical Biochemistry Laboratory. The reference intervals for
the parameters were determined using indirect and non-parametric percentile
estimation method.

Results: In
the study, the following respective lower and upper limits for the studied
parameters were determined- AFP: 0.52, 3.76 IU/ml; CA 15.3: 5.0, 37.60 IU/ml;
CA 19.9: 2.46, 29.5 IU/ml; CA 125: 2.89, 22.7 IU/ml; CEA: 0.11, 3.67 ng/ml;
fPSA: 0.02, 0.75 ng/ml; PSA: 0.14, 2.31 ng/ml; and TG: 0.34, 30.13 ng/ml.

Conclusion: This study
demonstrates that the reference intervals quoted by the manufacturers for the
parameters examined do not perfectly coincide with the reference intervals that
are specific to our population. Establishing local reference intervals
increases the utility of screening tests. 

Anahtar Kelimeler

Tumour markers, reference intervals, Kahramanmaraş region

Kaynakça

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