Habituel Abortus Olan Gebelerde Homosistein Folik Asid ve Vit B12 Seviyelerinin Değerlendirilmesi

Year 2021, Volume: 16 Issue: 3, 417 - 420, 01.11.2021

Gürkan Çıkım Abdullah Tok

https://doi.org/10.17517/ksutfd.895874

Cited By: 1

Abstract

Tekrarlayan gebelik kaybı iki veya daha fazla başarısız klinik gebelik veya intrauterin olması gerekmeyen ardışık üç gebelik kaybı olarak tanımlanır(3). Tekrarlayan gebelik kayıplarında homosistein düzeylerinin arttığını yada değişmediğini gösteren çalışmalar mevcuttur. Bu çalışmada, tekrarlayan gebelik kayıplarında serbest radikal benzeri etki gösteren homosistein ve homosisitein’in atılımında önemli fonksiyonlara sahip olan B12 ve folik asit düzeylerinde değişim olup olmadığı amaçlandı.

Gereç ve Yöntem: Bu çalışma, Kahramanmaraş Necip Fazıl Şehir Hastanesi Kadın Doğum ve Çocuk Hastalıkları ek binasında, retrospektif olarak ocak ve aralık 2020 tarihleri arasında 1. trimester tekrarlayan gebelik kaybı nedeniyle başvuran, 30 tekrarlayan gebelik kaybı olan hasta (Grup I) ve 1. trimesterde bulunan herhangi bir şikayeti olmayan 30 sağlıklı gebede (Grup II) plazma homosistein, serum folik asit ve vitamin B12 düzeyleri değerlendirildi.

Bulgular: Homosistein düzeyleri (µmol/L), Grup I: 17,6 ± 9,5, Grup II: 11,8 ± 4,6, Vitamin B12 düzeyleri (ng/L): Grup I: 233,4 ± 69,5, Grup II: 262,4 ± 76,7, folik asit düzeyleri (µg/L): Grup I: 7,7 ± 3,3, Grup II: 11,3 ± 3,7 olarak saptandı. Homosistein düzeylerinde; tekrarlayan gebelik kaybı olan grupta (Grup I) istatistiksel olarak anlamlı yükseklik saptandı (p<0.05). Folik asit düzeylerinde; tekrarlayan gebelik kaybı olan grupta (Grup I) istatistiksel olarak anlamlı düşüklük bulundu (p<0.05). Vitamin B12 düzeylerinde gruplar arasında istatistiksel olarak anlamlı bir fark görülmedi (p=.0.186). Yaşlar arasında istatistiksel olarak anlamlı bir fark saptanmadı (p=0.210).
Sonuç: Tekrarlayan gebelik kaybı olan hastalarda, homosistein, vitamin B12, folik asit düzeylerinin ethiolojide önemli bir etken olduğunu düşünmekteyiz

Keywords

tekrarlayan gebelik kaybı, folik asit, homosistein

HOMOCYSTEIN PHOLIC ACID AND VIT B12 LEVELS IN RECURRENT PREGNANCY LOSSES

Abstract

HOMOCYSTEIN PHOLIC ACID AND VIT B12 LEVELS IN RECURRENT PREGNANCY LOSSES
Summary;
Recurrent pregnancy loss is defined as two or more unsuccessful clinical pregnancies or three consecutive pregnancies that are not necessarily intrauterine (3). There are studies showing that homocysteine levels increase or do not change in recurrent pregnancy losses. In this study, it was aimed whether there was a change in B12 and folic acid levels, which have important functions in the excretion of free radical-like homocysteine and homocysteine in recurrent pregnancy losses.

Materials and Methods: This study included 30 patients with recurrent pregnancy loss (Group I) and 1. Plasma homocysteine, serum folic acid and vitamin B12 levels were evaluated in 30 healthy pregnant women (Group II) in the trimester without any complaints.

Results: Homocysteine levels (µmol / L), Group I: 17.6 ± 9.5, Group II: 11.8 ± 4.6, Vitamin B12 levels (ng / L): Group I: 233.4 ± 69, 5, Group II: 262.4 ± 76.7, folic acid levels (µg / L): Group I: 7.7 ± 3.3, Group II: 11.3 ± 3.7. At homocysteine levels; A statistically significant increase was found in the group with recurrent pregnancy loss (Group I) (p <0.05). At folic acid levels; A statistically significant decrease was found in the group with recurrent pregnancy loss (Group I) (p <0.05). There was no statistically significant difference in vitamin B12 levels between the groups (p = .0.186). There was no statistically significant difference between ages (p = 0.210).
Conclusion: We think that homocysteine, vitamin B12 and folic acid levels are important factors in ethiology in patients with recurrent pregnancy loss.

Keywords

recurrent pregnancy loss,, homocysteine, folic acid

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