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Nonfonksiyonel Hipofiz Adenomlarının Cerrahi Endikasyonları ve Yönetimi

Year 2018, Volume: 10 Issue: 1, 19 - 22, 30.01.2018

Abstract

Aktif hormon sekresyonu yapmayan hipofiz tümörleri nonfonksiyonel adenom olarak

adlandırılmaktadır. Tüm hipofiz adenomları içerisindeki oranları %30-35’dir. Bunların

ekseriside (%80-90) gonodotropik adenomlar tarafından oluşturulmaktadır. Hastalar

genellikle nörolojik semptomlar ya da hipofizer yetmezlik şeklinde klinik gösterirler.

Nonfonksyonel adenomu bulunan hastaların tedavisindeki amaçlar; nörolojik semptomların

düzeltilmesi, nükse müsaade etmeyecek şekilde mümkünse makroadenom dokusunun

tamamen çıkartılması ve normal hipofiz dokusunun basısı sonucu gelişen hormonal

yetmezliğin yönetimidir.

References

  • 1. Dekkers OM, Hammer S, de Keizer RJ, Roelfsema F, Schutte PJ, Smit JW et al. The natural course of non-functioning pituitary macroadenomas.Eur J Endocrinol. 2007 Feb;156(2):217-24. 2. Molitch ME. Nonfunctioning pituitary tumors and pituitary incidenta- lomas.EndocrinolMetabClin North Am. 2008 Mar;37(1):151-71, xi. 3. Nawar RN, AbdelMannan D, Selman WR, Arafah BM.Pituitary tumor apoplexy: a review. J IntensiveCareMed. 2008 Mar;23(2):75-90. 4. Dekkers OM, Pereira AM, Romijn JA. Treatment and follow-up of clinicallynon-functioning pituitary macroadenomas.J Clin Endocrinol Metab. 2008 Oct;93(10) 3717-26. Epub 2008 Aug 5. 5. Ceylan S, Anik I, Koc K, Ciftci E, Cabuk B. Endoscopic approach to cavernous sinus aneurysm.Turk Neurosurg. 2013;23(3):404-6. 6. Inder WJ, Hunt PJ. Glucocorticoid replacement in pituitary surgery: guidelines for perioperative assessment and management. J Clin Endocrinol Metab. 2002 Jun;87(6):2745-50. 7. Ausiello JC, Bruce JN, Freda PUPostoperative assessment of the patient after transsphenoidal pituitary surgery.Pituitary. 2008;11(4):391 8. Adams JR, Blevins LS Jr, Allen GS, Verity DK, Devin JK. Disorders of water me-tabolism following transsphenoidal pituitary surgery: a single institution's experi-ence.Pituitary. 2006;9(2):93-9. 9. Murad MH, Fernández-Balsells MM, Barwise A, Gallegos- Orozco JF, Paul A, Lane MA, et all. Outcomes of surgical treatment for nonfunctioning pituitary adenomas: a systematic review and meta-analysis.ClinEndocrinol (Oxf). 2010 Dec;73(6):777-91. 10. Woollons AC, Hunn MK, Rajapakse YR, Toomath R, Hamilton DA, Conaglen JV, et all. Non-functioning pituitary adenomas: indications for postoperative radiother-apy.Clin Endocrinol (Oxf). 2000 Dec;53(6):713-7. 11. Tsang RW, Brierley JD, Panzarella T, Gospodarowicz MK, Sutcliffe SB, Simpson WJ Radiation therapy for pituitary adenoma: treatment outcome and prognostic fac-tors.Int J RadiatOncolBiolPhys. 1994;30(3):557. 12. McCord MW, Buatti JM, Fennell EM, Mendenhall WM, Marcus RB Jr, Rhoton AL et all. Radiotherapy for pituitary adenoma: long-term outcome and sequelae.Int J RadiatOncolBiolPhys. 1997;39(2):437. 13. van den Bergh AC, van den Berg G, Schoorl MA, Sluiter WJ, van der Vliet AM, Hoving EW et all. Immediate postoperative radiotherapy in residual nonfunctioning pituitary adenoma: beneficial effect on local control without additional negative im-pact on pituitary function and life expectancy.Int J RadiatOncolBiolPhys. 2007;67(3):863. 14. Dekkers OM, Pereira AM, Romijn JA. Treatment and follow-up of clinically non-functioning pituitary macroadenomas. J ClinEndocrinolMetab. 2008 Oct;93(10):3717-26. Epub 2008 Aug 5. 15. Karavitaki N, Thanabalasingham G, Shore HC, Trifanescu R, Ansorge O, Meston N, et all. Do the limits of serum prolactin in disconnection hyperprolactinaemia need re-definition? A study of 226 patients with histologically verified non-functioning pituitary macroadenoma.Clin Endocrinol (Oxf). 2006 Oct;65(4):524-9.
Year 2018, Volume: 10 Issue: 1, 19 - 22, 30.01.2018

Abstract

References

  • 1. Dekkers OM, Hammer S, de Keizer RJ, Roelfsema F, Schutte PJ, Smit JW et al. The natural course of non-functioning pituitary macroadenomas.Eur J Endocrinol. 2007 Feb;156(2):217-24. 2. Molitch ME. Nonfunctioning pituitary tumors and pituitary incidenta- lomas.EndocrinolMetabClin North Am. 2008 Mar;37(1):151-71, xi. 3. Nawar RN, AbdelMannan D, Selman WR, Arafah BM.Pituitary tumor apoplexy: a review. J IntensiveCareMed. 2008 Mar;23(2):75-90. 4. Dekkers OM, Pereira AM, Romijn JA. Treatment and follow-up of clinicallynon-functioning pituitary macroadenomas.J Clin Endocrinol Metab. 2008 Oct;93(10) 3717-26. Epub 2008 Aug 5. 5. Ceylan S, Anik I, Koc K, Ciftci E, Cabuk B. Endoscopic approach to cavernous sinus aneurysm.Turk Neurosurg. 2013;23(3):404-6. 6. Inder WJ, Hunt PJ. Glucocorticoid replacement in pituitary surgery: guidelines for perioperative assessment and management. J Clin Endocrinol Metab. 2002 Jun;87(6):2745-50. 7. Ausiello JC, Bruce JN, Freda PUPostoperative assessment of the patient after transsphenoidal pituitary surgery.Pituitary. 2008;11(4):391 8. Adams JR, Blevins LS Jr, Allen GS, Verity DK, Devin JK. Disorders of water me-tabolism following transsphenoidal pituitary surgery: a single institution's experi-ence.Pituitary. 2006;9(2):93-9. 9. Murad MH, Fernández-Balsells MM, Barwise A, Gallegos- Orozco JF, Paul A, Lane MA, et all. Outcomes of surgical treatment for nonfunctioning pituitary adenomas: a systematic review and meta-analysis.ClinEndocrinol (Oxf). 2010 Dec;73(6):777-91. 10. Woollons AC, Hunn MK, Rajapakse YR, Toomath R, Hamilton DA, Conaglen JV, et all. Non-functioning pituitary adenomas: indications for postoperative radiother-apy.Clin Endocrinol (Oxf). 2000 Dec;53(6):713-7. 11. Tsang RW, Brierley JD, Panzarella T, Gospodarowicz MK, Sutcliffe SB, Simpson WJ Radiation therapy for pituitary adenoma: treatment outcome and prognostic fac-tors.Int J RadiatOncolBiolPhys. 1994;30(3):557. 12. McCord MW, Buatti JM, Fennell EM, Mendenhall WM, Marcus RB Jr, Rhoton AL et all. Radiotherapy for pituitary adenoma: long-term outcome and sequelae.Int J RadiatOncolBiolPhys. 1997;39(2):437. 13. van den Bergh AC, van den Berg G, Schoorl MA, Sluiter WJ, van der Vliet AM, Hoving EW et all. Immediate postoperative radiotherapy in residual nonfunctioning pituitary adenoma: beneficial effect on local control without additional negative im-pact on pituitary function and life expectancy.Int J RadiatOncolBiolPhys. 2007;67(3):863. 14. Dekkers OM, Pereira AM, Romijn JA. Treatment and follow-up of clinically non-functioning pituitary macroadenomas. J ClinEndocrinolMetab. 2008 Oct;93(10):3717-26. Epub 2008 Aug 5. 15. Karavitaki N, Thanabalasingham G, Shore HC, Trifanescu R, Ansorge O, Meston N, et all. Do the limits of serum prolactin in disconnection hyperprolactinaemia need re-definition? A study of 226 patients with histologically verified non-functioning pituitary macroadenoma.Clin Endocrinol (Oxf). 2006 Oct;65(4):524-9.
There are 1 citations in total.

Details

Primary Language Turkish
Subjects ​Internal Diseases
Journal Section makaleler
Authors

Bilgehan Solmaz

Publication Date January 30, 2018
Published in Issue Year 2018 Volume: 10 Issue: 1

Cite

APA Solmaz, B. (2018). Nonfonksiyonel Hipofiz Adenomlarının Cerrahi Endikasyonları ve Yönetimi. Klinik Tıp Aile Hekimliği, 10(1), 19-22.
AMA Solmaz B. Nonfonksiyonel Hipofiz Adenomlarının Cerrahi Endikasyonları ve Yönetimi. Aile Hekimliği. January 2018;10(1):19-22.
Chicago Solmaz, Bilgehan. “Nonfonksiyonel Hipofiz Adenomlarının Cerrahi Endikasyonları Ve Yönetimi”. Klinik Tıp Aile Hekimliği 10, no. 1 (January 2018): 19-22.
EndNote Solmaz B (January 1, 2018) Nonfonksiyonel Hipofiz Adenomlarının Cerrahi Endikasyonları ve Yönetimi. Klinik Tıp Aile Hekimliği 10 1 19–22.
IEEE B. Solmaz, “Nonfonksiyonel Hipofiz Adenomlarının Cerrahi Endikasyonları ve Yönetimi”, Aile Hekimliği, vol. 10, no. 1, pp. 19–22, 2018.
ISNAD Solmaz, Bilgehan. “Nonfonksiyonel Hipofiz Adenomlarının Cerrahi Endikasyonları Ve Yönetimi”. Klinik Tıp Aile Hekimliği 10/1 (January 2018), 19-22.
JAMA Solmaz B. Nonfonksiyonel Hipofiz Adenomlarının Cerrahi Endikasyonları ve Yönetimi. Aile Hekimliği. 2018;10:19–22.
MLA Solmaz, Bilgehan. “Nonfonksiyonel Hipofiz Adenomlarının Cerrahi Endikasyonları Ve Yönetimi”. Klinik Tıp Aile Hekimliği, vol. 10, no. 1, 2018, pp. 19-22.
Vancouver Solmaz B. Nonfonksiyonel Hipofiz Adenomlarının Cerrahi Endikasyonları ve Yönetimi. Aile Hekimliği. 2018;10(1):19-22.