<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.4 20241031//EN"
        "https://jats.nlm.nih.gov/publishing/1.4/JATS-journalpublishing1-4.dtd">
<article         dtd-version="1.4">
            <front>

                <journal-meta>
                                    <journal-id></journal-id>
            <journal-title-group>
                                                                                    <journal-title>Konuralp Medical Journal</journal-title>
            </journal-title-group>
                                        <issn pub-type="epub">1309-3878</issn>
                                                                                            <publisher>
                    <publisher-name>Duzce University</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id/>
                                                                                                                                                                                            <title-group>
                                                                                                                                                            <article-title>Doğum Sonrası Kilo Kaybında Emzirmenin Rolü; Anne Plazma Ghrelin, Serum Leptin ve Lipid Düzeylerinin Anne Sütüyle İlişkisi</article-title>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                <name>
                                    <surname>Z</surname>
                                    <given-names>Karataş</given-names>
                                </name>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20121201">
                    <day>12</day>
                    <month>01</month>
                    <year>2012</year>
                </pub-date>
                                        <volume>4</volume>
                                        <issue>3</issue>
                                        <fpage>12</fpage>
                                        <lpage>18</lpage>
                        
                        <history>
                                    <date date-type="received" iso-8601-date="20150810">
                        <day>08</day>
                        <month>10</month>
                        <year>2015</year>
                    </date>
                                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 2009, Konuralp Medical Journal</copyright-statement>
                    <copyright-year>2009</copyright-year>
                    <copyright-holder>Konuralp Medical Journal</copyright-holder>
                </permissions>
            
                                                                                                                        <abstract><p>Amaç: Bebeklerin beslenme şekline göre anne sütü (AS) ghrelin, leptin ve lipid düzeylerinin anne kan düzeyleri ve annenin antropometrisi ile ilişkisini araştırmak. Gereç ve Yöntem: Çalışma grubunu oluşturan 62 anne bebeklerin beslenme şekillerine göre Anne Sütü (AS), AS + formül mama (AS+FM), formül mama (FM) olarak üç gruba ayrıldı. Tüm anneler laktasyonun ortalama ikinci ve beşinci ayında iki kez değerlendirildi. Bulgular: İlk değerlendirmede AS grubunda formül mama (FM) grubu annelerine göre plazma total / aktif ghrelin oranı ve serum leptin düzeylerinin düşük olduğu saptandı (p</p></abstract>
                                                            
            
                                                                                        <kwd-group>
                                                    <kwd>Laktasyon</kwd>
                                                    <kwd>   Anne Sütü</kwd>
                                                    <kwd>   Ghrelin</kwd>
                                                    <kwd>   Leptin</kwd>
                                                    <kwd>   Lipid</kwd>
                                            </kwd-group>
                            
                                                                                                                                                    </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">Rooney BL, Schauberger CW. Excess pregnancy weight gain and long-term obesity: one decade later. Obstet Gynecol 2002;100(2):245-52.</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">Linne Y, Neovius M. Identification of women at risk of adverse weight development following pregnancy. Int J Obesity 2006;30(8):1234-9.</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">Brawarsky P, Stotland NE, Jackson RA, et al. Pre-pregnancy and pregnancy-related factors and the risk of excessive or inadequate gestational weight gain. Int J Gynecol Obstet 2005;91(2):125-31.</mixed-citation>
                    </ref>
                                    <ref id="ref4">
                        <label>4</label>
                        <mixed-citation publication-type="journal">Gunderson EP, Quesenberry CP, Lewis CE, et al. Development of overweight associated with childbearing depends on smoking habit: the Coronary Artery Risk Development in Young Adults (CARDIA) study. Obes Res 2004;12(12):2041-53.</mixed-citation>
                    </ref>
                                    <ref id="ref5">
                        <label>5</label>
                        <mixed-citation publication-type="journal">Stuebe AM, Oken E, Gillman MW. Associations of diet and physical activity during pregnancy with risk for excessive gestational weight gain. Am J Obstet Gynecol 2009;201(1):58.</mixed-citation>
                    </ref>
                                    <ref id="ref6">
                        <label>6</label>
                        <mixed-citation publication-type="journal">Oken E, Taveras EM, Popoola FA, et al. Television, walking, and diet: associations with postpartum weight retention. Am J Prev Med 2007;32(4):305-11.</mixed-citation>
                    </ref>
                                    <ref id="ref7">
                        <label>7</label>
                        <mixed-citation publication-type="journal">Rutishauser IHE, Carlin JB. Body mass index and duration of breast feeding: a survival analysis during the first six months of life. J Epidemiol Community Health 1992;46(6):559-65.</mixed-citation>
                    </ref>
                                    <ref id="ref8">
                        <label>8</label>
                        <mixed-citation publication-type="journal">Oddy WH, Li J, Landsborough L, et al. The association of maternal overweight and obesity with breastfeeding duration. J Pediatr 2006;149(2):185-91.</mixed-citation>
                    </ref>
                                    <ref id="ref9">
                        <label>9</label>
                        <mixed-citation publication-type="journal">Donath SM, Amir LH. Maternal obesity and initiation and duration of breastfeeding: data from the longitudinal study of Australian children. Matern Child Nutr 2008;4(3):163-70.</mixed-citation>
                    </ref>
                                    <ref id="ref10">
                        <label>10</label>
                        <mixed-citation publication-type="journal">Li R, Fein SB, Grummer-Strawn LM. Do Infants Fed From Bottles Lack Self-regulation of Milk Intake Compared With Directly Breastfed Infants? Pediatrics 2010;125(6):1386-93.</mixed-citation>
                    </ref>
                                    <ref id="ref11">
                        <label>11</label>
                        <mixed-citation publication-type="journal">Savino F, Fissore MF, Liguori SA, et al. Can hormones contained in mothers&#039; milk account for the beneficial effect of breast-feeding on obesity in children? Clin Endocrinol 2009;71(6):757-65.</mixed-citation>
                    </ref>
                                    <ref id="ref12">
                        <label>12</label>
                        <mixed-citation publication-type="journal">Petruchke T, Rotrig K, Hauner H. Transforming growth factor beta inhibits the differentiation of human adipocyte precursor cells in primary culture. Int J Obes Metab Disord 1994;18(8):532-6.</mixed-citation>
                    </ref>
                                    <ref id="ref13">
                        <label>13</label>
                        <mixed-citation publication-type="journal">Hamosh M. Bioactive factors in human milk. Pediatr Clin North Am 2001;48(1):69-86.</mixed-citation>
                    </ref>
                                    <ref id="ref14">
                        <label>14</label>
                        <mixed-citation publication-type="journal">Claud EC, Savidge T, Walker WA. Modulation of human intestinal epithelial cell IL-8 secretion by human milk factors. Pediatr Res 2003;53(3):419-25.</mixed-citation>
                    </ref>
                                    <ref id="ref15">
                        <label>15</label>
                        <mixed-citation publication-type="journal">Van der Lely AJ, Tschöp M, Heiman ML, et al. Biological, Physiological, Pathophysiological, and Pharmacological Aspects of Ghrelin. Endocrine Reviews 2004;25(3):426-57.</mixed-citation>
                    </ref>
                                    <ref id="ref16">
                        <label>16</label>
                        <mixed-citation publication-type="journal">Kojima M, Kangawa K. Ghrelin: structure and function. Physiol Rev 2005;85(2):495-522.</mixed-citation>
                    </ref>
                                    <ref id="ref17">
                        <label>17</label>
                        <mixed-citation publication-type="journal">Hosoda H, Kojima M, Kangawa K. Biological, physiological, and pharmacological aspects of ghrelin. J Pharmacol Sci 2006;100(5):398-410.</mixed-citation>
                    </ref>
                                    <ref id="ref18">
                        <label>18</label>
                        <mixed-citation publication-type="journal">Davenport AP, Bonner TI, Foord SM, et al. International Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution and function. Pharmacol Rev 2005;57(4):541-6.</mixed-citation>
                    </ref>
                                    <ref id="ref19">
                        <label>19</label>
                        <mixed-citation publication-type="journal">Bedendi I, Alloatti G, Marcantoni A, et al. Cardiac effects of ghrelin and its endogenous derivates desoctanoyl ghrelin and des-Gln14-ghrelin. Eur J Pharmacol 2003;476(1-2):87-95.</mixed-citation>
                    </ref>
                                    <ref id="ref20">
                        <label>20</label>
                        <mixed-citation publication-type="journal">Broglio F, Gottero C, Prodam F, et al. Non-acylated ghrelin counteracts the metabolic but not the endocrine response to acylated ghrelin in humans. J Clin Endocrinol Metab 2004;89(6):3062-5.</mixed-citation>
                    </ref>
                                    <ref id="ref21">
                        <label>21</label>
                        <mixed-citation publication-type="journal">Bluher S, Mantzoros CS. The role of leptin in regulating neuroendocrine function in humans. J Nutr 2004;134(9):2469-74.</mixed-citation>
                    </ref>
                                    <ref id="ref22">
                        <label>22</label>
                        <mixed-citation publication-type="journal">Hosoda H, Doi K, Nagaya N, et al. Optimum collection and storage conditions for ghrelin measurements: octanoyl modification of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples. Clin Chem 2004;50(6):1077-80.</mixed-citation>
                    </ref>
                                    <ref id="ref23">
                        <label>23</label>
                        <mixed-citation publication-type="journal">Aydin S, Aydin S, Ozkan Y, et al. Ghrelin is present in human colostrum, transitional and mature milk. Peptides 2006;27(4):878-82.</mixed-citation>
                    </ref>
                                    <ref id="ref24">
                        <label>24</label>
                        <mixed-citation publication-type="journal">Kierson JA, Dimatteo DM, Locke RG, et al. Ghrelin and cholecystokinin in term and preterm human breast milk. Acta Paediatr 2006;95(8):991-5.</mixed-citation>
                    </ref>
                                    <ref id="ref25">
                        <label>25</label>
                        <mixed-citation publication-type="journal">Ilcol YO, Hizli B. Active and total ghrelin concentrations increase in breast milk during lactation. Acta Paediatr 2007;96(11):1632-9.</mixed-citation>
                    </ref>
                                    <ref id="ref26">
                        <label>26</label>
                        <mixed-citation publication-type="journal">Dundar NO, Dundar B, Cesur G, et al. Ghrelin and Adiponectin Levels in Colostrum, Cord Blood and Maternal Serum. Pediatr Int 2010;52(4):622-5.</mixed-citation>
                    </ref>
                                    <ref id="ref27">
                        <label>27</label>
                        <mixed-citation publication-type="journal">Savino F, Liguori SA, Oggero R, et al. Maternal BMI and serum leptin concentration of infants in the first year of life. Acta Paediatr 2006;95(4):414-8.</mixed-citation>
                    </ref>
                                    <ref id="ref28">
                        <label>28</label>
                        <mixed-citation publication-type="journal">Pelleymounter MA, Cullen MJ, Baker MB, et al. Effects of the obese gene product on body weight regülation in ob/ob mice, Science 1995;269(5223):540-3.</mixed-citation>
                    </ref>
                                    <ref id="ref29">
                        <label>29</label>
                        <mixed-citation publication-type="journal">Smith-Kirwin SM, O&#039;Connor DM, De Johnston J, et al. Leptin expression in human mammary epithelial cells and breast milk. J Clin Endocrinol Metab 1998;83(5):1810-3.</mixed-citation>
                    </ref>
                                    <ref id="ref30">
                        <label>30</label>
                        <mixed-citation publication-type="journal">Houseknecht KL, McGuire MK, Portocarrero CP, et al. Leptin is present in human milk and is related to maternal plasma leptin concentrations and adiposity. Biochem Biophys Res Commun 1997;240(3):742-7.</mixed-citation>
                    </ref>
                                    <ref id="ref31">
                        <label>31</label>
                        <mixed-citation publication-type="journal">Ucar B, Kirel B, Bor O, et al. Breast milk leptin concentrations in initial and terminal milk samples: relationships to maternal and infant plasma leptin concentrations, adiposity, serum glucose, insulin, lipid and lipoprotein levels. J Pediatr Endocrinol Metab 2000;13(2):149-56.</mixed-citation>
                    </ref>
                                    <ref id="ref32">
                        <label>32</label>
                        <mixed-citation publication-type="journal">Aydin S, Ozkan Y, Erman F, et al. Presence of obestatin in breast milk: relationship among obestatin, ghrelin, and leptin in lactating women. Nutrition 2008;24(7-8):689-93.</mixed-citation>
                    </ref>
                                    <ref id="ref33">
                        <label>33</label>
                        <mixed-citation publication-type="journal">Maffei M, Halaas J, Ravussin E, et al. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995;1(11):1155-61.</mixed-citation>
                    </ref>
                                    <ref id="ref34">
                        <label>34</label>
                        <mixed-citation publication-type="journal">Wang J, Obici S, Morgan K, et al. Overfeeding rapidly induces leptin and insulin resistance. Diabetes 2001;50(12):2786-91.</mixed-citation>
                    </ref>
                                    <ref id="ref35">
                        <label>35</label>
                        <mixed-citation publication-type="journal">Petridou E, Mantzoros CS, Belechri M, et al. Neonatal leptin levels are strongly associated with female gender, birth length, IGF-I levels and formula feeding. Clin Endocrinol (Oxf) 2005;62(3):366-71.</mixed-citation>
                    </ref>
                                    <ref id="ref36">
                        <label>36</label>
                        <mixed-citation publication-type="journal">Savino F, Costamagna M, Prino A, et al. Leptin levels in breast-fed and formula-fed infants. Acta Paediatr 2002;91(9):897-902.</mixed-citation>
                    </ref>
                                    <ref id="ref37">
                        <label>37</label>
                        <mixed-citation publication-type="journal">Bielicki J, Huch R, von Mandach U. Time-course of leptin levels in term and preterm human milk. Eur J Endocrinol 2004;151(2):271-6.</mixed-citation>
                    </ref>
                                    <ref id="ref38">
                        <label>38</label>
                        <mixed-citation publication-type="journal">Denis RG, Williams G, Vernon RG. Regulation of serum leptin and its role in the hyperphagia of lactation in the rat. J Endocrinol 2003;176(2):193-203.</mixed-citation>
                    </ref>
                                    <ref id="ref39">
                        <label>39</label>
                        <mixed-citation publication-type="journal">Johnstone LE, Higuchi T. Food intake and leptin during pregnancy and lactation. Prog Brain Res 2001;133(1):215-27.</mixed-citation>
                    </ref>
                                    <ref id="ref40">
                        <label>40</label>
                        <mixed-citation publication-type="journal">Yu WH, Kimura M, Walczewska A, et al. Role of leptin in hypothalamic-pituitary function. Proc Natl ACad Sci USA 1997;94(3):1023-8.</mixed-citation>
                    </ref>
                                    <ref id="ref41">
                        <label>41</label>
                        <mixed-citation publication-type="journal">Butte NF, Hopkinson JM, Nicolson MA. Leptin in human reproduction: Serum leptin levels in pregnant and lactating women. J Clin Endocrinol Metab 1997;82(2):585-9.</mixed-citation>
                    </ref>
                                    <ref id="ref42">
                        <label>42</label>
                        <mixed-citation publication-type="journal">Korbonits M, Goldstone AP, Gueorguiev M, et al. Ghrelin-a hormone with multiple functions. Front Neuroendocrinol 2004;25(1):27-68.</mixed-citation>
                    </ref>
                                    <ref id="ref43">
                        <label>43</label>
                        <mixed-citation publication-type="journal">Ikezaki A, Hosoda H, Ito K, et al. Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents. Diabetes 2002;51(12):3408-11.</mixed-citation>
                    </ref>
                                    <ref id="ref44">
                        <label>44</label>
                        <mixed-citation publication-type="journal">Ng PC, Lee CH, Lam CW, et al. Ghrelin in preterm and term newborns: relation to anthropometry, leptin and insulin. Clin Endocrinol (Oxf) 2005;63(2):217-22.</mixed-citation>
                    </ref>
                                    <ref id="ref45">
                        <label>45</label>
                        <mixed-citation publication-type="journal">Shiotani A, Miyanishi T, Uedo N, et al. Helicobacter pylori infection is associated with reduced circulating ghrelin levels independent of body mass index. Helicobacter 2005;10(5):373-8.</mixed-citation>
                    </ref>
                                    <ref id="ref46">
                        <label>46</label>
                        <mixed-citation publication-type="journal">Beaumont NJ, Skinner VO, Tan TM, et al. Ghrelin can bind to a species of high density lipoprotein associated with paraoxonase. J Biol Chem 2003;278(11):8877-80.</mixed-citation>
                    </ref>
                                    <ref id="ref47">
                        <label>47</label>
                        <mixed-citation publication-type="journal">Choi KM, Lee J, Lee KW, et al. The associations between plasma adiponectin, ghrelin levels and cardiovascular risk factors. Eur J Endocrinol 2004;150(5):715-8.</mixed-citation>
                    </ref>
                                    <ref id="ref48">
                        <label>48</label>
                        <mixed-citation publication-type="journal">Park HS, Lee KU, Kim YS, et al. Relationships between fasting plasma ghrelin levels and metabolic parameters in children and adolescents. Metabolism 2005;54(7):925-9.</mixed-citation>
                    </ref>
                                    <ref id="ref49">
                        <label>49</label>
                        <mixed-citation publication-type="journal">Kirel B, Tekin N, Tekin B, et al. Cord blood leptin levels: relationship to body weight, body mass index, sex and insulin and cortisol levels of maternal-newborn pairs at delivery. J Pediatr Endocrinol Metab 2000;13(1):71-7.</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
