Assessment of central corneal thickness, intraocular pressure and retinal nerve fiber layer thickness at women with polycystic ovary syndrome

Year 2017, Volume: 9 Issue: 2, 142 - 145, 06.07.2017

Kuddusi Teberik , Hakan Sağlam Alper Başbuğ , Musa Karaaslan Murat Kaya Mehmet Ali Sungur

https://doi.org/10.18521/ktd.298734

Cited By: 2

Abstract

Objective:
To
compare intraocular pressure, central cornea thickness, anterior chamber depth,
axial length and thickness of retina nerve fiber layer between women with
polycystic ovary syndrome and healthy at the same age segment.

Methods:
Between August 2015-January 2016, 46 with polycystic
ovary syndrome and 53
healthy, were included. After performing refraction measurements, Intraocular
pressure, central cornea thickness, anterior chamber depth, axial length and
retina nerve fiber layer thickness were investigated. In
the statistical analysis of the data, the Independent Samples t test was
utilized in the comparison of groups.

Results:
While
mean age was 23.43±4.52 (16-35) in the group with polycystic ovary syndrome,
mean age level was found as 24.09±6.14 (18-41) among the controls (P=0,549).
Intraocular pressure values were measured and found as 17.73±2.67 mmHg in the
group with polycystic ovary syndrome, while the values were 15.21±2.42 mmHg in
the controls (P <0,001). Although it was
79.41±10.28 µm in the group with
polycystic ovary syndrome, retina nerve fiber layer thickness in the nasal
quadrant was found to be 73.83±10.98 µm among
the controls.

Conclusion: We found that the
increased levels seen in intraocular pressure and retina nerve fiber layer
thickness in the nasal quadrants of the patients with polycystic ovary syndrome
were statistically significance. Hence, we recommend that the patients with
polycystic ovary syndrome should be closely evaluated as to eye assessment.

Keywords

Anterior chamber depth, Axial length, Central cornea thickness, Intraocular pressure, Polycystic ovary syndrome

Polikistik over sendromlu kadınlarda santral kornea kalınlığı, göz içi basıncı ve retinal sinir lifi tabakası kalınlığının değerlendirilmesi

Abstract

Amaç: Aynı yaş segmentinde polikistik over sendromlu ve sağlıklı kadınlar arasındaki göz içi basıncı, santral kornea kalınlığı, ön kamara derinliği, aksiyel uzunluk ve retina sinir lifi tabakası kalınlığını karşılaştırmak.

Gereç ve Yöntem : Ağustos 2015-Ocak 2016 tarihleri arasında polikistik over sendromlu 46  ve 53 sağlıklı  kadın dahil edildi. Refraksiyon ölçümleri alındıktan sonra, göziçi basıncı, santral kornea kalınlığı, ön kamara derinliği, aksiyel uzunluk ve retina sinir lifi tabakası kalınlığı incelendi. Verilerin istatistiksel olarak değerlendirilmesinde grupların karşılaştırılması amacıyla Independent Samples t test kullanılmıştır.

Bulgular: Polikistik over sendromlu grupta yaş ortalaması 23.43 ± 4.52 (16-35) iken, kontroller arasında ortalama yaş düzeyi 24.09 ± 6.14 (18.54) olarak bulundu (p = 0,549). Polikistik over sendromlu grupta göz içi basıncı değerleri 17.73 ± 2.67 mmHg, kontrollerde 15.21 ± 2.42 mmHg bulundu (P <0,001). Nazal kadrandaki retina sinir lifi kalınlığı polikistik over sendromlu grupta 79,41±10,28 mikron iken kontrol grubunda 73,83±10,98 mikron olduğu bulundu (P <0,001).

Sonuç: Polikistik over sendromlu hastaların nazal kadrandaki retina sinir lifi tabakası kalınlığı ve  göz içi basıncında görülen artmış düzeylerin istatistiksel olarak anlamlı olduğu bulduk. Bu nedenle, polikistik over sendromlu hastaların göz muayenesi açısından yakından değerlendirilmesini önerilmekteyiz.

Keywords

Ön kamara derinliği, aksiyel uzunluk, santral kornea kalınlığı, göz içi basıncı, polikistik over sendromu, retina sinir lifi tabakası kalınlığı

References

• 1. Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab 2004;89(6):2745-9.
• 2. Stein IF, Leventhal ML. Amenorrhea associated with bilateral polycystic ovaries. Am J Obstet Gynecol 1935;29(2):181-91.
• 3. Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004;19(1): 41-7.
• 4. Dunaif A, Segal KR, Futterweit W, Dobrjansky A. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 1989;38(9):1165-74.
• 5. Apridonidze T, Essah PA, Iuorno MJ, Nestler JE. Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2005;90(4):1929-35.
• 6. Ehrmann DA, Barnes RB, Rosenfield RL, Cavaghan MK, Imperial J. Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Diabetes Care 1999;22(1):141-6.
• 7. Conway GS, Agrawal R, Betteridge DJ, Jacobs HS. Risk factors for coronary artery disease in lean and obese women with the polycystic ovary syndrome. Clin Endocrinol (Oxf) 1992;37(2):19-25.
• 8. Brent H, Johnstone E, Dorais J, Silver B, Peterson CM, Hotaling J. Female infertility, infertility-associated diagnoses, and comorbidities: a review. J Assist Reprod Genet 2017;34(2):167–77.
• 9. Gilling-Smith C, Willis DS, Beard RW, Franks S. Hypersecretion of androstenedione by isolated thecal cells from polycystic ovaries. J Clin Endocrinol Metab 1994;79(4):1158-65.
• 10. Fuchsjager-Mayrl G, Nepp J, Schneeberger C, et al. Identification of estrogen and progesterone receptor mRNA expression in the conjunctiva of premenopausal women. Invest Ophthalmol Vis Sci 2002;43(9):2841-4.