Distribution of lymphoid neoplasms in Northeast Turkey: A retrospective analysis of 1136 cases according to the World Health Organization classification

Year 2020, Issue: 2, 208 - 215, 04.06.2020

Zeynep Sağnak Yılmaz Ümit Çobanoğlu

https://doi.org/10.18521/ktd.568680

Cited By: 1

Abstract

Objective: Malignant lymphoma is one of the
most common cancer type around the world. In this study, the
distribution and demographic characteristics of the histologic subgroups of
mature lymphoid neoplasms in Northeast Turkey were investigated.

Methods: The study consists of 1136
patients diagnosed as mature lymphoid neoplasm between 2008 and 2014. The
demographic data of the patients were analysed and histological subgrouping was
performed according to the World Health Organization classification.

Results: Mature B-cell neoplasms
accounted for 79.2% (n=900) of all lymphoid neoplasms, Hodgkin lymphoma (HL)
for 10.9% (n=124), mature T/natural killer-cell neoplasms for 9% (n=102), and
histiocytic and dendritic cell neoplasms for 0.9% (n=10). In our study, the
most common subtypes of lymphoid neoplasms were as follows: diffuse large
B-cell lymphoma (n=261; 23%), plasma cell myeloma (n=252; 22.2%), chronic
lymphocytic leukemia/small lymphocytic lymphoma (n=230; 20.2%), mycosis fungoides (MF) (n=66; 5.8%) and nodular
sclerosing type classical HL (n=63; 5.5%). Only 2.9% of the cases of
non-Hodgkin lymphoma (NHL) were follicular lymphoma. All patients with HL were
diagnosed by a lymph node biopsy. However, 48.1% of the patients with NHL arose
from extranodal sites.

Conclusion: This is the first study investigating the
distribution of lymphoid neoplasms in Northeast Anatolia region with the review
of the literature. The present study showed that the epidemiologic features
similar to those reported in Western and Asian countries, whereas some subtypes
showed distinct features. The high frequency of MF and
the low frequency of
follicular lymphoma are
interesting findings of this study.

Keywords

lymphoma, lymphoid neoplasms, WHO classification, subtype, distribution

Türkiye’nin Kuzeydoğusundaki Lenfoid Neoplazm Vakalarının Dağılımı:1136 Vakanın Dünya Sağlık Örgütü Sınıflamasına Göre Retrospektif İncelenmesi

Abstract

Amaç:Malign lenfoma dünyada en sık görülen kanser tiplerinden biridir. Bu çalışmada, Türkiye’ ninkuzeydoğusundaki matür lenfoid neoplazm vakalarının histolojik alt gruplarının dağılımları ve demografik özellikleri incelenmiştir.Gereç ve Yöntem: Bu çalışmada 2008 ve 2014 yılları arasında matür lenfoid neoplazm tanısı almış 1136 hasta yer almaktadır. Hastaların demografik verileri araştırılıp Dünya Sağlık Örgütü sınıflamasına göre histolojik alt grupları tespit edilmiştir.Bulgular: Tüm lenfoid neoplazilerin %79.2’ si (n=900) matür B hücreli neoplaziler, %10.9’ u (n=124) Hodgkin lenfoma (HL), %9’ u (n=102) matür T/natural killer hücreli neoplaziler, %0.9’ u (n=10) histiyositik ve dendritik hücreli neoplazilerden oluşmaktadır. Çalışmamızda lenfoid neoplazilerin en sık görülen alt tipleri şöyledir: diffüz büyük B hücreli lenfoma (n=261; %23), plazma hücreli miyelom (n=252; %22.2), kronik lenfositik lösemi/ küçük lenfositik lenfoma (n=230; %20.2), mikozis fungoides (MF) (n=66; %5.8) ve nodular sklerozan tip HL (n=63; %5.5). Non-Hodgkin lymphoma (NHL) tanılı vakaların yalnızca %2.9’ u folliküler lenfoma tanılıdır. HL hastalarının tümü lenf nodu biyopsisinden tanı almıştır. Bununla birlikte NHL vakalarının %48.1’ i ekstranodal bölge yerleşimlidir.Sonuç: Bu çalışma Kuzeydoğu Anadolu’ daki lenfoid neoplazilerin dağılımını literatürverileriyle karşılaştırarak inceleyen ilk çalışma niteliğindedir. Çalışmamızda batı ve Asya ülkeleri ile benzer epidemiyolojik veriler elde edilmesine rağmen bazı alt gruplarda farklılıklar dikkati çekmektedir. MF’ in sıklıkla görülmesi ve folliküler lenfomanın nadir izlenmesi bu çalışmanın çarpıcı bulgularıdır

Keywords

Lenfoma, Lenfoid neoplaziler, WHO sınıflaması, Alt tip, Dağılım

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