Use of Vanoxerine Consta In Cocaine Addiction: A Case Report

Year 2019, , 69 - 71, 28.11.2019

Sümeyye Demirbay Neslihan Cansel Hatice Birgül Cumurcu Zehra Algan

https://doi.org/10.35365/ctjpp.19.special1.20

Abstract

Cocaine abuse is a serious health problem in many regions of the world, however, there are no proven effective drugs for the treatment of cocaine addiction. In this presentation,diagnosis, treatment and monitoring processes of a 33-year-old male patient, using vanoxerine constants in the treatment of cocaine addiction, will be shared. In the story taken, it was learned that the patient started to use cocaine 7-8 months ago.After the patient was applied a intramuscular treatment, 394,2 mg of vanoxerine consta, three times with three months intervals, it was observed that withdrawal symptoms and cocaine desire decreased.In addition, one-year follow-up of the patient revealed that his well-being continued and the urine substance panels were negative.Vanoxerin limits cocaine-induced increase in extracellular dopamine by competing with cocaine in the dopamine transporter region.Cocaine abuse is a harmful habit spreading to the world, causing socioeconomic problems.

Keywords

addiction, cocaine, vanoxerine

References

• Andersen, P. H. (1989). The dopamine uptake inhibitor GBR 12909: selectivity and molecular mechanism of action.European Journal of Pharmacology, 166, 493-509.
• Andersen, P. H. (1989). The dopamine uptake inhibitor GBR 12909: selectivity and molecular mechanism of action. European journal of pharmacology, 166(3), 493-504
• Castells, X., Casas, M., Pérez‐Mañá, C., Roncero, C., Vidal, X., & Capella, D. (2010). Efficacy of psychostimulant drugs for cocaine dependence. Cochrane Database of Systematic Reviews, (2).
• Fensbo, C., Montgomery, S. A., Andersen, J., Hallstrom, C., Schonbeck, G., Zwaan, M., M0oler Nielsen, E. M., Olafsson, K., Ingwersen, S. H. & Skrumsager, B. K. (1990). GBR 12909: A dose response relationship of the selective dopamine uptake inhibitor in major depression. XVIIth Congress of Collegium Internationale Neuro-Psychopharmacologicum, Kyoto. Abstract 0-11-9-3.
• Glowa, J.R., Wojnicki, F.H.E., Matecka, D., Rice, K.C., Rothman, R.B. (1995b) Effects of dopamine reuptake inhibitors on food and cocaine maintained responding II: comparison with other drugs and repeated administration .Experimental and Clinical Psychopharmacology 3:232–239.
• Hanzlick, R., Gowitt, G.T., (1991). Cocaine metabolite detection in homicide victims. The Journal of the American Medical Association 265:760–761.
• Holman, R.B. (1994). Biological effects of central nervous system stimulants. Addiction, 89(11), 1435-1441.
• Hyman, S.E. (1996) Addiction to cocaine and amphetamine. Neuron, 16(5), 901-904.
• Kalivas, P.W.; Duffy, P. (1990) Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens. Synapse, 5(1), 48-58.
• Koob, G.F. Nestler, E.J. (1997). The neurobiology of drug addiction. The Journal of Neuropsychiatry and Clinical Neurosciences, 9(3), 482-497.
• Luoh, H.F. Kuo, T.B. Chan, S.H. Pan, W.H. (1994). Power spectral analysis of electroencephalographic desynchronization induced by cocaine in rats: correlation with microdialysis evaluation of dopaminergic neurotransmission at the medial prefrontal cortex. Synapse, 16(1), 29-35.
• Matsumoto, N., Khrestian, C. M., Ryu, K., Lacerda, A. E., Brown, A. M., & Waldo, A. L. (2010). Vanoxerine, a new drug for terminating atrial fibrillation and flutter. Journal of cardiovascular electrophysiology, 21(3), 311-319.
• Rothman, R.B., Mele, A., Reid, A.A., Akunne, H.C., Greig, N., Thurkauf, A. (1991). GBR 12909 antagonizes the ability of cocaine to elevate extracellular levels of dopamine. Pharmacology Biochemistry and Behavior, 40:387–397.
• Volkow, N.D., Wang, G.J., Fowler, J.S., Logan, J., Gatley, S.J., Wong, C. (1999). Reinforcing effects of psychostimulants in humans areassociated with increases in brain dopamine and occupancyof D2 receptors.Journal of Pharmacology and Experimental Therapeutics 291:409–415.
• Volkow, N. D., Wang, G. J., Fowler, J. S., Logan, J., Franceschi, D., Maynard, L., ... & Swanson, J. M. (2002). Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: therapeutic implications. Synapse, 43(3), 181-187.