Kastamonu Medical Journal

2757-9336

Kastamonu University

10.66235/kumj.1906837

Neurology and Neuromuscular Diseases

Nöroloji ve Nöromüsküler Hastalıklar

Systemic inflammatory markers in vestibular neuritis and BPPV: A single-center retrospective study

https://orcid.org/0000-0003-3676-6238

Özen Gökmuharremoğlu

Özge

KASTAMONU UNIVERSITY, SCHOOL OF MEDICINE, MEDICINE PR.

https://orcid.org/0000-0002-0964-0405

Aydin

Yusuf

KASTAMONU UNIVERSITY, SCHOOL OF MEDICINE, MEDICINE PR.

03 12 2026

6 1 91 97 09 22 2025 10 23 2025

Aims: This study aimed to compare systemic inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), derived NLR (dNLR), systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI), in patients with vestibular neuritis (VN) and benign paroxysmal positional vertigo (BPPV) and to evaluate their potential role in differential diagnosis.Methods: In this retrospective study, 109 patients diagnosed with VN (n=52) or BPPV (n=57) at Kastamonu Training and Research Hospital were included between January 2024 and December 2024. Demographic characteristics, clinical data, and laboratory parameters (leukocyte, neutrophil, lymphocyte, monocyte, platelet, CRP, and albumin levels) were recorded. NLR, dNLR, MLR, PLR, SII [(platelet × neutrophil)/lymphocyte], and SIRI [(neutrophil × monocyte)/lymphocyte] were calculated.Results: The two groups were similar regarding age and sex distribution; however, bilateral involvement was significantly more common in the BPPV group (p=0.004). The VN group showed significantly higher leukocyte (p=0.027) and neutrophil (p=0.004) counts and significantly lower albumin levels (p=0.001). Among inflammatory markers, NLR (p=0.012), SII (p=0.023) and SIRI (p=0.035) were found to be significantly higher in VN patients than in BPPV patients.Conclusion: The significant increase in NLR, SII, and SIRI levels in VN patients compared with BPPV patients suggests a more prominent role of inflammatory mechanisms in the pathogenesis of vestibular neuritis. These readily available and inexpensive biomarkers may serve as supportive tools in the differential diagnosis of peripheral vertigo in clinical practice.

Vestibular neuritis benign paroxysmal positional vertigo systemic inflammatory markers neutrophil-to-lymphocyte ratio systemic immune-inflammation index

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