<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.4 20241031//EN"
        "https://jats.nlm.nih.gov/publishing/1.4/JATS-journalpublishing1-4.dtd">
<article  article-type="research-article"        dtd-version="1.4">
            <front>

                <journal-meta>
                                                                <journal-id>kırıkkale uni med j</journal-id>
            <journal-title-group>
                                                                                    <journal-title>The Journal of Kırıkkale University Faculty of Medicine</journal-title>
            </journal-title-group>
                                        <issn pub-type="epub">2148-9645</issn>
                                                                                            <publisher>
                    <publisher-name>Kirikkale University</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id pub-id-type="doi">10.24938/kutfd.1838659</article-id>
                                                                <article-categories>
                                            <subj-group  xml:lang="en">
                                                            <subject>Health Services and Systems (Other)</subject>
                                                    </subj-group>
                                            <subj-group  xml:lang="tr">
                                                            <subject>Sağlık Hizmetleri ve Sistemleri (Diğer)</subject>
                                                    </subj-group>
                                    </article-categories>
                                                                                                                                                        <title-group>
                                                                                                                        <article-title>FUNCTIONAL OUTCOMES OF PATIENTS TREATED WITH MODULAR TUMOR RESECTION PROSTHESIS FOLLOWING PROXIMAL HUMERUS TUMOR</article-title>
                                                                                                                                                                                                <trans-title-group xml:lang="tr">
                                    <trans-title>Proksimal Humerus Tümörü Sonrası Modüler Tümör Rezeksiyon Protezi ile Tedavi Edilen Hastaların Fonksiyonel Sonuçları</trans-title>
                                </trans-title-group>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0001-7034-2522</contrib-id>
                                                                <name>
                                    <surname>Gezer</surname>
                                    <given-names>Mehmet Can</given-names>
                                </name>
                                                                    <aff>Clinic of Orthopedics and Traumatology Mamak State Hospital, ANKARA, TÜRKİYE</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0003-0783-510X</contrib-id>
                                                                <name>
                                    <surname>Karaca</surname>
                                    <given-names>Mustafa Onur</given-names>
                                </name>
                                                                    <aff>Department of Orthopedics and Traumatology, Faculty of Medicine, Ankara University, ANKARA, TÜRKİYE</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0003-0433-0253</contrib-id>
                                                                <name>
                                    <surname>Armangil</surname>
                                    <given-names>Mehmet</given-names>
                                </name>
                                                                    <aff>Department of Orthopedics and Traumatology, Faculty of Medicine, Ankara University, ANKARA, TÜRKİYE</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0002-7669-6206</contrib-id>
                                                                <name>
                                    <surname>Yıldız</surname>
                                    <given-names>Yusuf</given-names>
                                </name>
                                                                    <aff>Department of Orthopedics and Traumatology, Faculty of Medicine, Ankara University, ANKARA, TÜRKİYE</aff>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20260427">
                    <day>04</day>
                    <month>27</month>
                    <year>2026</year>
                </pub-date>
                                        <volume>28</volume>
                                        <issue>1</issue>
                                        <fpage>102</fpage>
                                        <lpage>106</lpage>
                        
                        <history>
                                    <date date-type="received" iso-8601-date="20251226">
                        <day>12</day>
                        <month>26</month>
                        <year>2025</year>
                    </date>
                                                    <date date-type="accepted" iso-8601-date="20260126">
                        <day>01</day>
                        <month>26</month>
                        <year>2026</year>
                    </date>
                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 1999, The Journal of Kırıkkale University Faculty of Medicine</copyright-statement>
                    <copyright-year>1999</copyright-year>
                    <copyright-holder>The Journal of Kırıkkale University Faculty of Medicine</copyright-holder>
                </permissions>
            
                                                                                                <abstract><p>Objectives: This study aims to evaluate the functional outcomes of patients undergoing hemiarthroplasty with modular tumor prostheses for proximal humeral tumors. Material and Methods: A total of 28 patients were included in the study, with an average follow-up of 71.11 months. The mean age of participants was 47.8 years, and the cohort included various tumor types, including osteosarcoma and chondrosarcoma. Functional outcomes were assessed using the Modified Musculoskeletal Tumor Society evaluation system, the American Shoulder and Elbow Surgeons score, and the Visual Analog Scale  for pain.Results: The postoperative results demonstrated an average Modified Musculoskeletal Tumor Society score of 21.68 and an American Shoulder and Elbow Surgeons score of 52.71, reflecting substantial improvements in both shoulder function and pain management. Notably, the Visual Analog Scale scores decreased significantly, from a preoperative average of 6.57 to a postoperative average of 3.79. This reduction in pain intensity indicates that patients experienced a marked alleviation of discomfort following the surgical intervention.Conclusion: Modular tumor prosthesis represents a reliable and effective treatment option for proximal humerus tumors. Although low infection and recurrence rates were noted, further research with larger sample sizes and longer follow-up is necessary to fully understand the long-term durability of the prosthesis and its potential complications, particularly in younger, more active patients.</p></abstract>
                                                                                                                                    <trans-abstract xml:lang="tr">
                            <p>Amaç: Bu çalışmanın amacı, proksimal humerus tümörleri nedeniyle modüler tümör protezi ile hemiartroplasti uygulanan hastaların fonksiyonel sonuçlarını değerlendirmektir.Gereç ve Yöntemler: Çalışmaya ortalama 71,11 aylık takip süresine sahip toplam 28 hasta dâhil edildi. Katılımcıların ortalama yaşı 47,8 yıl olup; osteosarkom ve kondrosarkom başta olmak üzere farklı tümör tipleri mevcuttu. Fonksiyonel sonuçlar Modifiye Muskuloskeletal Tümör Derneği değerlendirme sistemi, American Shoulder and Elbow Surgeons değerlendirme skoru ve ağrı düzeyini belirlemek için Görsel Analog Skala kullanılarak değerlendirildi.Bulgular: Ameliyat sonrası değerlendirmelerde ortalama Modifiye Muskuloskeletal Tümör Derneği skoru 21,68 ve American Shoulder and Elbow Surgeons değerlendirme skoru 52,71 olarak saptandı. Bu bulgular, omuz fonksiyonu ve ağrı kontrolünde belirgin bir iyileşme olduğunu göstermektedir. Özellikle Görsel Analog Skala skorlarının ameliyat öncesi ortalama 6,57’den ameliyat sonrası ortalama 3,79’a anlamlı şekilde düşmesi, cerrahi girişim sonrasında hastaların ağrılarında belirgin bir azalma olduğunu ortaya koymaktadır.Sonuç: Modüler tümör protezi, proksimal humerus tümörlerinin tedavisinde güvenilir ve etkili bir seçenek olarak değerlendirilebilir. Düşük enfeksiyon ve nüks oranları gözlenmiş olsa da, protezin uzun vadeli dayanıklılığını ve olası komplikasyonlarını—özellikle daha genç ve daha aktif hastalarda—tam olarak anlamak için daha büyük örneklem büyüklükleriyle ve daha uzun takip süreleriyle yapılacak ileri araştırmalara ihtiyaç vardır.</p></trans-abstract>
                                                            
            
                                                            <kwd-group>
                                                    <kwd>Modular tumor prosthesis</kwd>
                                                    <kwd>  hemiarthroplasty</kwd>
                                                    <kwd>  proximal humerus tumor</kwd>
                                                    <kwd>  functional outcomes</kwd>
                                            </kwd-group>
                                                        
                                                                            <kwd-group xml:lang="tr">
                                                    <kwd>Modüler tümör protezi</kwd>
                                                    <kwd>  hemiartroplasti</kwd>
                                                    <kwd>  proksimal humerus tümörü</kwd>
                                                    <kwd>  fonksiyonel sonuçlar</kwd>
                                            </kwd-group>
                                                                                                            </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">Cardinale U, Pisanu F, Pes M, Ciatti C, Manunta AF, Doria C. Inverse shoulder tumor megaprosthesis after large bone resection in massive metastasis of the proximal humerus. Acta Biomed. 2023;94(Suppl 2):e2023001.</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">D’Arienzo A, Dey Hazra R, Wang P, et al. Proximal humerus reconstruction after tumor resection: an overview of surgical management. Adv Orthop. 2021;2021:6634572.</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">Pinnamaneni S, Damron TA. Proximal humerus reconstruction in orthopedic oncology. J Cancer Metastasis Treat. 2021;7:35.</mixed-citation>
                    </ref>
                                    <ref id="ref4">
                        <label>4</label>
                        <mixed-citation publication-type="journal">Schneider KN, Wilder R, Velazquez VM, et al. What is the implant survivorship and functional outcome after total humeral replacement in patients with primary bone tumors? Clin Orthop Relat Res. 2021;479(8):1754-1764.</mixed-citation>
                    </ref>
                                    <ref id="ref5">
                        <label>5</label>
                        <mixed-citation publication-type="journal">Trikoupis IG, Giannoudis PV, Tamiolakis D, et al. Prosthetic reconstruction of the shoulder after resection of proximal humerus bone tumor. Orthopedics. 2022;45(6):e335-e341.</mixed-citation>
                    </ref>
                                    <ref id="ref6">
                        <label>6</label>
                        <mixed-citation publication-type="journal">El Motassime A, Bouzid W, Chawla A, et al. Functional outcomes and shoulder instability in reconstruction of proximal humerus metastases. Curr Oncol. 2023;30(4):3571-3579.</mixed-citation>
                    </ref>
                                    <ref id="ref7">
                        <label>7</label>
                        <mixed-citation publication-type="journal">Malawer MM, Wittig JC. Overview of resections around the shoulder girdle: anatomy, surgical considerations and classification. In: Pollock RE, ed. Principles and Practice of Surgical Oncology. 3rd ed. Lippincott Williams &amp; Wilkins; 2019:211-228.</mixed-citation>
                    </ref>
                                    <ref id="ref8">
                        <label>8</label>
                        <mixed-citation publication-type="journal">Teunis T, Nota SPFT, Hornicek FJ, Schwab JH, Lozano-Calderón SA. Outcome after reconstruction of the proximal humerus for tumor resection: a systematic review. Clin Orthop Relat Res. 2014;472(7):2245-2253.</mixed-citation>
                    </ref>
                                    <ref id="ref9">
                        <label>9</label>
                        <mixed-citation publication-type="journal">Guven MF, Aslan L, Botanlıoğlu H, Kaynak G, Kesmezacar H, Babacan M. Functional outcome of reverse shoulder tumor prosthesis in the treatment of proximal humerus tumors. J Shoulder Elbow Surg. 2016;25(1):e1-e6.</mixed-citation>
                    </ref>
                                    <ref id="ref10">
                        <label>10</label>
                        <mixed-citation publication-type="journal">Wang S, Li Z, Zhang X, et al. Early functional and therapeutic effect of reversed tumour shoulder prosthesis reconstruction after proximal humerus tumour resection. Front Surg. 2022;9:911234.</mixed-citation>
                    </ref>
                                    <ref id="ref11">
                        <label>11</label>
                        <mixed-citation publication-type="journal">Trovarelli G, Cappellari A, Angelini A, Pala E, Ruggieri P. What is the survival and function of modular reverse total shoulder prostheses in patients undergoing tumor resections in whom an innervated deltoid muscle can be preserved? Clin Orthop Relat Res. 2019;477(11):2495-2507.</mixed-citation>
                    </ref>
                                    <ref id="ref12">
                        <label>12</label>
                        <mixed-citation publication-type="journal">Holschen M, Siemes MK, Witt KA, Steinbeck J. Five-year outcome after conversion of hemiarthroplasty to reverse total shoulder arthroplasty. Bone Joint J. 2018;100-B(6):761-766.</mixed-citation>
                    </ref>
                                    <ref id="ref13">
                        <label>13</label>
                        <mixed-citation publication-type="journal">Chen CM, Wu PK, Tsai SW, Chen CF, Chen WM. Prognosis-based shoulder hemiarthroplasty after resection of proximal humeral malignancy. Artif Organs. 2017;41(12):1162-1172.</mixed-citation>
                    </ref>
                                    <ref id="ref14">
                        <label>14</label>
                        <mixed-citation publication-type="journal">Denissen JJPM, van der Geest ICM, Schreuder HW, et al. Functional outcomes after reverse shoulder megaprosthesis following resection of malignant bone tumor in the proximal humerus: a systematic review and meta-analysis. JSES Int. 2023;7(4):592-600.</mixed-citation>
                    </ref>
                                    <ref id="ref15">
                        <label>15</label>
                        <mixed-citation publication-type="journal">Grosel TW, Plummer DR, Mayerson JL, Scharschmidt TJ, Barlow JD. Reverse total shoulder arthroplasty provides stability and better function than hemiarthroplasty following resection of proximal humerus tumors. J Shoulder Elbow Surg. 2019;28(11):2147-2152.</mixed-citation>
                    </ref>
                                    <ref id="ref16">
                        <label>16</label>
                        <mixed-citation publication-type="journal">Grosel TW, Plummer DR, Mayerson JL, Scharschmidt TJ, Barlow JD. Oncologic reconstruction of the proximal humerus with a reverse total shoulder arthroplasty megaprosthesis. J Surg Oncol. 2018;118(6):867-872.</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
