kırıkkale uni med j

The Journal of Kırıkkale University Faculty of Medicine

2148-9645

Kirikkale University

10.24938/kutfd.1851671

Health Care Administration

Sağlık Kurumları Yönetimi

COMPARISON OF CARBAMAZEPINE AND LEVETIRACETAM MONOTHERAPY IN CHILDHOOD ROLANDIC EPILEPSY

Çocukluk Çağı Rolandik Epilepsi Hastalarında Karbamazepin ve Levetirasetam Monoterapilerinin Karşılaştırılması

https://orcid.org/0009-0003-9829-1423

Topçuoğlu

Fatma Hazal

Department of Pediatrics, Faculty of Medicine, Sütçü İmam University, KAHRAMANMARAŞ, TÜRKİYE

https://orcid.org/0000-0003-2680-515X

Turan

Mehmet

Department of Pediatrics, Faculty of Medicine, Sütçü İmam University, KAHRAMANMARAŞ, TÜRKİYE

https://orcid.org/0000-0001-5496-0988

Terzioğlu Öztürk

Sedef

Clinic of Pediatric Neurology, Necip Fazıl City Hospital, KAHRAMANMARAŞ, TÜRKİYE

https://orcid.org/0000-0003-0691-3591

Dilber

Cengiz

Division of Pediatric Neurology, Faculty of Medicine, Sütçü İmam University, Kahramanmaraş, Türkiye

04 27 2026

28 1 107 112 12 29 2025 02 20 2026

1999

The Journal of Kırıkkale University Faculty of Medicine

Objective: Rolandic epilepsy (RE) is the most common benign focal epilepsy of childhood. While carbamazepine (CBZ) has been widely used in treatment, levetiracetam (LEV) has become one of the first-line options in recent years due to its efficacy and good tolerability. The aim of this study was to compare CBZ and LEV monotherapies in the treatment of RE. Material and Methods: Thirty patients with RE (15 treated with CBZ and 15 with LEV) who were followed at Sütçü İmam University during the last three-year period were retrospectively analyzed. Demographic and clinical characteristics, including age, sex, age at seizure onset, seizure type, and seizure frequency, were evaluated. Changes in seizure frequency after treatment, treatment-related adverse effects, and electroencephalographic (EEG) response were systematically assessed. Results: Of the 30 patients, 20 (66.7%) were male and 10 (33.3%) were female. Twelve patients (80%) in the CBZ group and eight patients (53.3%) in the LEV group were male. The median age at diagnosis was 8.1 years (6.8-8.9), and the median age at treatment initiation was 8.1 years (7.0-8.8). There were no significant differences between the groups regarding sex distribution, age at diagnosis, or age at treatment initiation. No significant difference was found between the two treatment groups in terms of reduction in seizure frequency after treatment. EEG normalization during follow-up was observed in 9 patients (31%), with no significant difference between the groups in EEG normalization frequency or time to normalization. Treatment-related adverse effects were observed in 10 patients (33.3%), with no significant difference between the CBZ and LEV groups. Conclusion: Although no statistically significant differences were found between CBZ and LEV in terms of seizure control, adverse effects, and EEG outcomes, our findings support the use of LEV as an effective monotherapy option in the treatment of childhood RE.

Amaç: Rolandik epilepsi (RE), çocukluk çağının en sık görülen benign fokal epilepsisidir. Tedavide karbamazepin (CBZ) yaygın kullanılan bir antiepileptikken, levetirasetam (LEV) da son yıllarda etkinliği ve iyi tolere edilebilirliği sebebiyle ilk tercihlerden biri olarak yer almıştır. Çalışmamızın amacı RE tedavisinde CBZ ve LEV monoterapilerinin karşılaştırılmasıdır. Gereç ve Yöntemler: Son üç yılda Sütçü İman Üniversitesinde takip edilen 30 RE hastası (15 CBZ, 15 LEV) retrospektif olarak analiz edildi. Yaş, cinsiyet, nöbet başlangıç yaşı, nöbet tipi ve nöbet sıklığı gibi demografik ve klinik özellikler değerlendirildi. Tedavi sonrası nöbet sıklığındaki değişimler ve yan etkiler, tedaviye elektroensefalografi (EEG) yanıtı sistematik olarak incelendi. Bulgular: Çalışmamızdaki 30 hastanın 20’si erkek (%66,7), 10’u kızdı (%33,3). CBZ grubunun 12’si (%80) erkek, LEV grubunun 8’i (%53,3) erkekti. Grubun tanı yaşı 8,1 (6,8-8,9) yıl [median (%25-75)], tedavi başlama yaşı 8,1 (7,0-8,8) yıldı. Gruplar arasında cinsiyet, tanı ve tedavi başlanma yaşı açısından fark yoktu (sırayla p=0,245; 0,068; 0,085). Tedavi sonrası nöbet sıklığı azalmasında iki ilaç grubu arasında anlamlı fark bulunmadı. Tüm hastaların 9’unda (%31) tedavi süresinde EEG’de normale dönme olduğu görüldü. Gruplar arasında EEG’de düzelme sıklıkları açısından fark yoktu. EEG’nin normale dönme süresi CBZ grubunda 34 (16-36) ay, LEV grubunda 14 (7-33) aydı. EEG düzelme süresi karşılaştırmasında gruplar arasında anlamlı fark görülmedi. Tüm grupta 10 hastada (%33,3) tedaviye bağlı yan etki geliştiği görüldü. Yan etki sıklığı CBZ grubunda 3 (%20), LEV grubunda 7 (%46,7) idi ve aralarında anlamlı fark yoktu (p=0,245). Sonuç: RE tedavisinde nöbet kontrolü, yan etkiler ve EEG bulguları açısından CBZ ve LEV arasında istatistiksel olarak anlamlı bir fark olmamasına karşın, çalışmamız LEV’in etkili bir monoterapötik ajan olarak kullanımını desteklemektedir.

Rolandic epilepsy carbamazepine levetiracetam

Rolandik epilepsi karbamazepin levetirasetam

The authors received no financial support for the research.

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