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Multipl Sklerozda Oral Tedavi Seçenekleri

Year 2014, Volume: 16 Issue: 3, 28 - 32, 04.01.2016

Murat Alpua

https://doi.org/10.24938/kutfd.124901

Abstract

Relapsing Remitting Multipl Skleroz (RRMS) için tedavi seçenekleri gün geçtikçe artmaktadır. Bazı oral tedavi seçeneklerinin de tedavide fayda sağlayabileceği yakın zamanda yapılan çeşitli araştırmalarla gösterilmiştir. Ancak bu tedavi seçeneklerinin klinik faydalılığı ve güvenilirliği hakkında halen bazı şüpheler devam etmektedir. Bu derlemede oral ajanların etki mekanizmaları, etkinlikleri ve güvenilirlikleri hakkında şimdiye kadar yürütülmüş çalışmaların özetlenmesi amaçlanmıştır.

Keywords

Relapsing remitting multipl skleroz oral tedavi

References

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  • Cohen JA, Chun J. Mechanisms of fingolimod’s efficacy and adverse effects in multiple sclerosis. Ann Neurol. 2011; 69: 759–77.
  • Ingwersen J, Aktas O, Kuery P, Kieseier B, Boyko A, Hartung HP. Fingolimod in multiple sclerosis: mechanisms of action and clinical efficacy. Clin Immunol. 2012; 142(1): 15-24. Doi: 10.1016/j.clim.2011.10.008.
  • Cohen JA, Barkhof F, Comi G, Hartung HP, Khatri BO, Montalban X, Pelletier J, Capra R, Gallo P, Izquierdo G, Tiel-Wilck K, de Vera A, Jin J, Stites T, Wu S, Aradhye S, Kappos L; TRANSFORMS Study Group. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med. 2010; 362(5): 402-15.
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  • Kappos L, Radue EW, O'Connor P, Polman C, Hohlfeld R, Calabresi P, Selmaj K, Agoropoulou C, Leyk M, Zhang-Auberson L, Burtin P; FREEDOMS Study Group. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. NEngl J Med. 2010; 362: 387–401.
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  • Liliemark J. The clinical pharmacokinetics of cladribine. Clin Pharmacokinet. 1997; 32: 120-31.
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  • Fontoura P,Garren H. Multiple sclerosis therapies: molecular mechanisms and future. Results Probl Cell Differ. 2010; 51: 259-85.
  • O'Connor PW, Li D, Freedman MS, Bar-Or A, Rice GP, Confavreux C, Paty DW, Stewart JA, Scheyer R; Teriflunomide Multiple Sclerosis Trial Group; University of British Columbia MS/MRI Research Group. A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses. Neurology. 2006; 66: 894-900.
  • O'Connor P, Wolinsky JS, Confavreux C, Comi G, Kappos L, Olsson TP, Benzerdjeb H, Truffinet P, Wang L, Miller A, Freedman MS; TEMSO Trial Group. “Randomized trial of oral teriflunomide for relapsing multiple slerosis,” New Eng J Med. 2011; 365(14): 1293-1303.
  • Noseworthy JH, Wolinsky JS, Lublin FD, Whitaker JN, Linde A, Gjorstrup P, Sullivan HC. Linomide in relapsing and secondary progressive MS: part I: trial design and clinical results.North American Linomide Investigators. Neurology. 2000; 54: 1726-33.
  • Wolinsky JS, Narayana PA, Noseworthy JH, Lublin FD, Whitaker JN, Linde A, Gjörstrup P, Sullivan HC. Linomide in relapsing and secondary progressive MS: part II: MRI results. MRI Analysis Center of the University of Texas-Houston, Health Science Center, and the North American Linomide Investigators. Neurology. 2000; 54: 1734-41.
  • Brunmark C1, Runström A, Ohlsson L, Sparre B, Brodin T, Aström M, Hedlund G. The new orally active immunoregulator laquinimod (ABR-215062) effectively inhibits development and relapses of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2002; 130: 163-72.
  • Zou LP, Abbas N, Volkmann I, Nennesmo I, Levi M, Wahren B, Winblad B, Hedlund G, Zhu J. Suppression of experimental autoimmune neuritis by ABR-215062 is associated with altered Th1/Th2 balance and inhibited migration of inflammatory cells into the peripheral nevre tissue. Neuropharmacology. 2002; 42: 731-39.
  • Bruck W, Wegner C. Insight into the mechanism of laquinimod action. J Neurol Sci. 2011; 306: 173-79.
  • Kappos L, Gold R, Miller DH, Macmanus DG, Havrdova E, Limmroth V, Polman CH, Schmierer K, Yousry TA, Yang M, Eraksoy M, Meluzinova E, Rektor I, Dawson KT, Sandrock AW, O'Neill GN; BG-12 Phase IIb Study Investigators. Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study. Lancet. 2008; 372: 1463-72.
  • Gold R. Oral therapies for multiple sclerosis: a review of agents in phase III development or recently approved. CNS Drugs. 2011; 25: 37-52.
  • Fontoura P, Garren H. Multiple sclerosis therapies: molecular mechanisms and future. Results Probl Cell Differ. 2010; 51: 259-85.
  • Linker RA1, Lee DH, Ryan S, van Dam AM, Conrad R, Bista P, Zeng W, Hronowsky X, Buko A, Chollate S, Ellrichmann G, Brück W, Dawson K, Goelz S,Wiese S, Scannevin RH, Lukashev M, Gold R. Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 2011; 134:678-92.
  • Gold R, Kappos L, Bar-Or A. “Clinical efficacy of BG-12, an oral therapy, in relapsing-remitting multiple sclerosis:data from the phase 3 DEFINE trial,” in proceedings of the 5th Joint Teriannial Congress of European and Americas Committees for Treatment and Research in Multiple Sclerosis (ECTRIMS/ACTRIMS), Amsterdam, The Netherlands, October 2011.
  • Fox RJ, Miller DH, Phillips JT, Hutchinson M, Havrdova E, Kita M, Yang M, Raghupathi K, Novas M, Sweetser MT, Viglietta V, Dawson KT; CONFIRM Study Investigators. “Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis”. N Engl J Med. 2012; 367(12): 1087-97.
  • Gold R, Kappos L, Arnold DL, Bar-Or A, Giovannoni G, Selmaj K, Tornatore C, Sweetser MT, Yang M, Sheikh SI, Dawson KT; DEFINE Study Investigators. “Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis,” N Engl J Med. 2012; 367(12): 1098-107

Year 2014, Volume: 16 Issue: 3, 28 - 32, 04.01.2016

Murat Alpua

https://doi.org/10.24938/kutfd.124901

Abstract

References

  • Aktas O,Kury P, Kieseier B,Hartung HP. Fingolimod is a potential novel therapy for multiple sclerosis. Nat Rev Neurol. 2010; 6(7): 373-82. Doi: 10.1038/nrneurol.2010.76.
  • Cohen JA, Chun J. Mechanisms of fingolimod’s efficacy and adverse effects in multiple sclerosis. Ann Neurol. 2011; 69: 759–77.
  • Ingwersen J, Aktas O, Kuery P, Kieseier B, Boyko A, Hartung HP. Fingolimod in multiple sclerosis: mechanisms of action and clinical efficacy. Clin Immunol. 2012; 142(1): 15-24. Doi: 10.1016/j.clim.2011.10.008.
  • Cohen JA, Barkhof F, Comi G, Hartung HP, Khatri BO, Montalban X, Pelletier J, Capra R, Gallo P, Izquierdo G, Tiel-Wilck K, de Vera A, Jin J, Stites T, Wu S, Aradhye S, Kappos L; TRANSFORMS Study Group. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med. 2010; 362(5): 402-15.
  • Doi: 10.1056/NEJMoa0907839.
  • Kappos L, Antel J, Comi G, Montalban X, O'Connor P, Polman CH, Haas T, Korn AA, Karlsson G, Radue EW; FTY720 D2201 Study Group. Oral fingolimod (FTY720) for relapsing multiple sclerosis. N Engl J Med. 2006; 355: 1124–40.
  • Kappos L, Radue EW, O'Connor P, Polman C, Hohlfeld R, Calabresi P, Selmaj K, Agoropoulou C, Leyk M, Zhang-Auberson L, Burtin P; FREEDOMS Study Group. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. NEngl J Med. 2010; 362: 387–401.
  • Hartung HP, Aktas O, Kieseier B, Comi GC. Development of oral cladribine for the treatment of multiple sclerosis. J Neurol. 2010; 257: 163-70.
  • Liliemark J. The clinical pharmacokinetics of cladribine. Clin Pharmacokinet. 1997; 32: 120-31.
  • Giovannoni G, Cook S, Rammohan K, Rieckmann P, Sørensen PS, Vermersch P, Hamlett A, Viglietta V, Greenberg S; CLARITY study group. Sustained disease-activity-free status in patients with relapsing-remitting multiple sclerosis treated with cladribine tablets in the CLARITY study: a post-hoc and subgroup analysis. Lancet Neurol2011; 10: 329-37.
  • Fontoura P,Garren H. Multiple sclerosis therapies: molecular mechanisms and future. Results Probl Cell Differ. 2010; 51: 259-85.
  • O'Connor PW, Li D, Freedman MS, Bar-Or A, Rice GP, Confavreux C, Paty DW, Stewart JA, Scheyer R; Teriflunomide Multiple Sclerosis Trial Group; University of British Columbia MS/MRI Research Group. A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses. Neurology. 2006; 66: 894-900.
  • O'Connor P, Wolinsky JS, Confavreux C, Comi G, Kappos L, Olsson TP, Benzerdjeb H, Truffinet P, Wang L, Miller A, Freedman MS; TEMSO Trial Group. “Randomized trial of oral teriflunomide for relapsing multiple slerosis,” New Eng J Med. 2011; 365(14): 1293-1303.
  • Noseworthy JH, Wolinsky JS, Lublin FD, Whitaker JN, Linde A, Gjorstrup P, Sullivan HC. Linomide in relapsing and secondary progressive MS: part I: trial design and clinical results.North American Linomide Investigators. Neurology. 2000; 54: 1726-33.
  • Wolinsky JS, Narayana PA, Noseworthy JH, Lublin FD, Whitaker JN, Linde A, Gjörstrup P, Sullivan HC. Linomide in relapsing and secondary progressive MS: part II: MRI results. MRI Analysis Center of the University of Texas-Houston, Health Science Center, and the North American Linomide Investigators. Neurology. 2000; 54: 1734-41.
  • Brunmark C1, Runström A, Ohlsson L, Sparre B, Brodin T, Aström M, Hedlund G. The new orally active immunoregulator laquinimod (ABR-215062) effectively inhibits development and relapses of experimental autoimmune encephalomyelitis. J Neuroimmunol. 2002; 130: 163-72.
  • Zou LP, Abbas N, Volkmann I, Nennesmo I, Levi M, Wahren B, Winblad B, Hedlund G, Zhu J. Suppression of experimental autoimmune neuritis by ABR-215062 is associated with altered Th1/Th2 balance and inhibited migration of inflammatory cells into the peripheral nevre tissue. Neuropharmacology. 2002; 42: 731-39.
  • Bruck W, Wegner C. Insight into the mechanism of laquinimod action. J Neurol Sci. 2011; 306: 173-79.
  • Kappos L, Gold R, Miller DH, Macmanus DG, Havrdova E, Limmroth V, Polman CH, Schmierer K, Yousry TA, Yang M, Eraksoy M, Meluzinova E, Rektor I, Dawson KT, Sandrock AW, O'Neill GN; BG-12 Phase IIb Study Investigators. Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study. Lancet. 2008; 372: 1463-72.
  • Gold R. Oral therapies for multiple sclerosis: a review of agents in phase III development or recently approved. CNS Drugs. 2011; 25: 37-52.
  • Fontoura P, Garren H. Multiple sclerosis therapies: molecular mechanisms and future. Results Probl Cell Differ. 2010; 51: 259-85.
  • Linker RA1, Lee DH, Ryan S, van Dam AM, Conrad R, Bista P, Zeng W, Hronowsky X, Buko A, Chollate S, Ellrichmann G, Brück W, Dawson K, Goelz S,Wiese S, Scannevin RH, Lukashev M, Gold R. Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 2011; 134:678-92.
  • Gold R, Kappos L, Bar-Or A. “Clinical efficacy of BG-12, an oral therapy, in relapsing-remitting multiple sclerosis:data from the phase 3 DEFINE trial,” in proceedings of the 5th Joint Teriannial Congress of European and Americas Committees for Treatment and Research in Multiple Sclerosis (ECTRIMS/ACTRIMS), Amsterdam, The Netherlands, October 2011.
  • Fox RJ, Miller DH, Phillips JT, Hutchinson M, Havrdova E, Kita M, Yang M, Raghupathi K, Novas M, Sweetser MT, Viglietta V, Dawson KT; CONFIRM Study Investigators. “Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis”. N Engl J Med. 2012; 367(12): 1087-97.
  • Gold R, Kappos L, Arnold DL, Bar-Or A, Giovannoni G, Selmaj K, Tornatore C, Sweetser MT, Yang M, Sheikh SI, Dawson KT; DEFINE Study Investigators. “Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis,” N Engl J Med. 2012; 367(12): 1098-107
There are 25 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Murat Alpua

Publication Date January 4, 2016
Submission Date January 4, 2016
Published in Issue Year 2014 Volume: 16 Issue: 3

Cite

APA Alpua, M. (2016). Multipl Sklerozda Oral Tedavi Seçenekleri. The Journal of Kırıkkale University Faculty of Medicine, 16(3), 28-32. https://doi.org/10.24938/kutfd.124901
AMA Alpua M. Multipl Sklerozda Oral Tedavi Seçenekleri. Kırıkkale Uni Med J. January 2016;16(3):28-32. doi:10.24938/kutfd.124901
Chicago Alpua, Murat. “Multipl Sklerozda Oral Tedavi Seçenekleri”. The Journal of Kırıkkale University Faculty of Medicine 16, no. 3 (January 2016): 28-32. https://doi.org/10.24938/kutfd.124901.
EndNote Alpua M (January 1, 2016) Multipl Sklerozda Oral Tedavi Seçenekleri. The Journal of Kırıkkale University Faculty of Medicine 16 3 28–32.
IEEE M. Alpua, “Multipl Sklerozda Oral Tedavi Seçenekleri”, Kırıkkale Uni Med J, vol. 16, no. 3, pp. 28–32, 2016, doi: 10.24938/kutfd.124901.
ISNAD Alpua, Murat. “Multipl Sklerozda Oral Tedavi Seçenekleri”. The Journal of Kırıkkale University Faculty of Medicine 16/3 (January 2016), 28-32. https://doi.org/10.24938/kutfd.124901.
JAMA Alpua M. Multipl Sklerozda Oral Tedavi Seçenekleri. Kırıkkale Uni Med J. 2016;16:28–32.
MLA Alpua, Murat. “Multipl Sklerozda Oral Tedavi Seçenekleri”. The Journal of Kırıkkale University Faculty of Medicine, vol. 16, no. 3, 2016, pp. 28-32, doi:10.24938/kutfd.124901.
Vancouver Alpua M. Multipl Sklerozda Oral Tedavi Seçenekleri. Kırıkkale Uni Med J. 2016;16(3):28-32.
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