Correlation and Assessment of Cost-Effectivity of Simultaneous PCT and CRP Measurements for Patients with Community-Acquired Pneumonia and COPD Inflamation

Year 2019, Volume: 21 Issue: 2, 239 - 248, 31.08.2019

Nermin Dindar Badem , Seydi Ali Peker Sedat Kaygusuz

https://doi.org/10.24938/kutfd.590431

Cited By: 1

Abstract

Objective: Bacterial infections are important
causes of morbidity and mortality. Serum procalcitonin and C-reactive protein
are significant indicators during the diagnosis, treatment and follow-up of
systemic inflammations and bacterial infections. In this study, correlation
between levels of procalcitonin, which has recently become commonly used in
infection cases, and C-reactive protein, the conventional indicator, were
investigated for patients whose final diagnoses were found as pneumonia and/or
COPD inflammation. Additionally, the study aimed to determine which among the two
indicators was cost-effective for the diagnosis and management of lower
respiratory infections.

Material and Methods: Procalcitonin and C-reactive protein
results of 4712 samples, which were gathered from 1948 patients and measured
simultaneously were assessed. Among the samples, 499 (10.6%) were from COPD
inflammation patients (Group I), 1480 (31.4%) were from pneumonia patients
(Group II), and the remaining 2733 (58%) were from COPD inflammation and
pneumonia patients (Group III).

Results: A strong positive correlation was
detected between C-reactive protein and procalcitonin levels (rho=0.512,
p<0.001). As for the assessments within the established groups I, II and
III, again a strong positive correlation was seen (rho=0.539, p<0.001;
rho=0.509, p<0.001; rho=0.511, p<0.001, respectively).

Conclusion: Procalcitonine was found to be
positively correlated to C-reactive protein and it was suggested that
procalcitonine could be used instead of the costly C reactive protein during
long-term infection care.

Keywords

Community-acquired pneumonia, COPD inflammation, procalcitonin, C-reactive protein

EŞ ZAMANLI PCT VE CRP İSTENEN TOPLUM KÖKENLİ PNÖMONİ VE KOAH ALEVLENMESİ OLAN HASTALARDA BU PARAMETRELERİN KORELASYONU VE MALİYET ETKİLİLİK AÇISINDAN DEĞERLENDİRİLMESİ

Abstract

Amaç: Bakteriyel enfeksiyonlar önemli
morbidite ve mortalite nedenidir. Serum prokalsitonin ve C-reaktif protein
sistemik inflamasyon ve bakteriyel enfeksiyonların tanı, tedavi ve takibinde
önemli belirteçlerdir. Bu çalışmada nihai tanıları pnömoni ve/veya KOAH
alevlenmesi olan hastalarda son zamanlarda enfeksiyon takibinde sıklıkla kullanılmaya
başlanan prokalsitonin ile klasik belirteç olarak kullanılan C-reaktif protein
düzeyleri arasındaki korelasyon araştırıldı. Ayrıca alt solunum yolu
enfeksiyonu tanısı ya da yönetimi için C-reaktif proteinin mi, prokalsitoninin
mi maliyet etkililik açısından yararlı olduğunu saptamayı amaçladık.

Gereç ve Yöntemler:
Toplam 1948 hastadan elde
edilmiş 4712 örnekten eş zamanlı çalışılan prokalsitonin ve C-reaktif protein
sonuçları değerlendirildi. Örneklerden 499’u (%10.6) KOAH alevlenmesi (Grup I),
1480’i (%31.4) pnömoni (Grup II) ve 2733 (%58)’i KOAH alevlenmesi ve pnömoni
(Grup III) tanısı almış hastaların örneklerinden oluşuyordu.

Bulgular: C-reaktif protein ve prokalsitonin
düzeyleri arasında pozitif güçlü korelasyon saptandı (rho=0.512, p<0.001).
Yine prokalsitonin ve C-reaktif protein arasındaki grup içi değerlendirmede
Grup I, Grup II ve Grup III’de pozitif güçlü korelasyon tespit edildi
(sırasıyla rho=0.539, p<0.001; rho=0.509, p<0.001; rho=0.511,
p<0.001).

Sonuç: Prokalsitoninin
C-reaktif protein ile korelasyon gösterdiği, enfeksiyonun ileri dönem takibinde
yüksek maliyetli prokalsitonin yerine C-reaktif protein ölçümünün
kullanılmasının uygun olacağı kanaatine varılmıştır.

Keywords

KOAH alevlenmesi, Toplum kökenli pnömoni, prokalsitonin, C-reaktif protein

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