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TESTİS TÜMÖRÜNDE GAMA GLUTAMİL TRANSPEPTİDAZ ETKİSİ; YENİ BİR BİYOBELİRTEÇ Mİ DOĞUYOR?

Year 2021, Volume: 23 Issue: 2, 309 - 317, 31.08.2021
https://doi.org/10.24938/kutfd.900045

Abstract

Amaç: Bu çalışmanın amacı testis tümörü hastalarında serum gama-glutamil transpeptidaz düzeyinin özellikle seminomatöz alt tipteki hastalıkta bir biyobelirteç olarak kullanılabilirliğinin, mevcut kullanımda olan biyobelirteçlere üstünlüğünün araştırılması ile sisplatin temelli kemoterapi alan hastalarda serum gama-glutamil transpeptidaz seviyelerinin kemoterapi yanıtı, devamı ve nefrotoksisitedeki rollerini incelemektir.
Gereç ve Yöntemler: Bu çalışma testis tümörü tanısı alıp radikal inguinal orşiektomi uygulanan hastaların verilerinin retrospektif olarak taranması şeklinde gerçekleştirildi. Yaş, tümör histolojisi, alt tipi ve evresi, tümör tarafı ve boyutu, mikrolithiazis ve testiküler intraepitelyal neoplazi varlığı, seminomlu hastalarda tümör boyutu ve rete testis invazyonu, non-seminomatöz hastalarda lenfovasküler invazyon varlığı ve embriyonel kanser yüzdesi, preoperatif ve postoperatif gama-glutamil transpeptidaz, alfa feto protein, laktat dehidrojenaz ve beta human chorionic gonadotropinin seviyeleri, postoperatif verilen tedavi (kemoterapi ve retroperitoneal lenf nodu diseksiyonu), sisplatin alma durumu ile sonrasında serum kreatinin seviyeleri ve kemoterapi cevabı gibi değişkenler çalışmada incelendi.
Bulgular: Çalışmamız, hariç tutma kriterleri sonrası toplam 96 hasta ile gerçekleştirildi. Serum gama-glutamil transpeptidaz değerinin preoperatif ve postoperatif seviyelerinin alfa feto protein, laktat dehidrojenaz ve beta human chorionic gonadotropinin ile hem seminom, hem de nonseminomatöz testis kanserlerinde korelasyonunun olmadığı izlenmiştir. Gama-glutamil transpeptidaz seviyesini predikte edebilecek faktörler olarak yaş, tümör histolojisi, seminom alt tipi, seminomda rete testis invazyonu ve seminomdaki tümör boyutunun anlamlı derecede ilişkili olduğu bulunmuştur.
Sonuç: Serum gama-glutamil transpeptidaz enzimi seminom hastalarında şu anki biyobelirteçlerden bağımsız olarak yeni bir biyobelirteç gibi görünmektedir. Daha ileri yaşı olan, klasik alt tipli seminom hastalarında kötü risk faktörleri olarak bilinen rete testis invazyonunu ve tümörün 4 cm’den büyük oluşunu destekleyen bir biyobelirteç olduğu sonucuna ulaşılmıştır.

Supporting Institution

Yok

Project Number

Yok

References

  • 1. Vaitukaitis JL, Braunstein GD, Ross GT. A radioimmunoassay which specifically measures human chorionic gonadotropin in the presence of human luteinizing hormone. Am J Obstet Gynecol. 1972;113:751.
  • 2. Waldmann TA, Mclntire KR. The use of a radioimmunoassay for alphafetoprotein in the diagnosis of malignancy. Cancer. 1974;34:1510.
  • 3. Javadpour N, Mclntire KR, Waldmann TA. Immunochemical determination of human chorionic gonadotropin (HCG) and alphafetoprotein (AFP) in sera and tumors of patients with testicular cancer. Null Cancer Inst Monogr. 1978;49:209-13.
  • 4. Rosen SW, Javadpour N, Calvert I, Kaminska J. Pregnancy-specific B glycoprotein (SP) is increased in certain non-seminomatous germ cell tumors. J Natl Cancer Inst. 1979;62:1439.
  • 5. Kohn J, Orr AH, McElwain TJ, Bentall M, Peckham MJ. Serum alpha-feto-protein in patients with testicular tumors. Lancet. 1976;2:433-6.
  • 6. Lange PH, Fraley EE. Serum alpha-fetoprotein and human chorionic gonadotropin in the treatment of patients with testicular tumors. Urol Clin Norrh Am. 1977;4:393.
  • 7. Wıllemse P, Sleıjfer D, Schraffordt K, De Bruijn HW, Oosterhuis JW, Brouwers TM et al. Tumor markers in patients with non-seminomatous germ cell tumors of the testis. Oncodeu Biol Med. 1981;2:117-28.
  • 8. Bosl JG, Geller İN, Cirrincione MS, Nisselbaum J, Vugrin D, Whitmore Jr WF et al. Serum tumor markers in patients with metastatic germ cell tumors of the testis. Am J Med. 1983;75:29-35.
  • 9. Perrin P, Ardiet C, Pommatau F. Tumor markers in germinal testis tumors. Acta Urologica Belgica. 1982;53:212-22.
  • 10. Scardino P, Cox H, Waldmann T, Mcintire KR, Mittemeyer B, Javadpour N. The value of serum tumor markers in the staging and prognosis of germ cell tumors of the testis. J Ural. 1977;118:994-9.
  • 11. Fraley E, Lange P, Kennedy B. Germ cell testicular cancer in adults. N Engl J Med. 1979;301:1370-7.
  • 12. Fishman WH, lnglis NR, Stolbach CC, Krant MJ. A serum alkaline phosphatase isoenzyme of human neoplastic cell origin. Cancer Res. 1968;28:150.
  • 13. Wahren B, Holmgren PA, Stigbrand T. Placental alkaline phosphatase, alphafetoprotein and carcinoembryonic antigen in testicular tumors: Tissue typing by means ofcytologic smear. Intl J Cuncer. 1979;24:749.
  • 14. Laishes BA, Ogawa K, Roberts E, Farber E. Gamma-glutamyl transpetidase: A positive marker for cultured rat liver cells derived from putative premalignant and malignant lesions. J Nafl Cancer Inst. 1978;60:1009.
  • 15. Krishnaswamy PR, Tate S, Meister A. Gamma, glutamyl transpeptidase of human seminal fluid. Liye Science. 1977;20:681.
  • 16. Galanski M. Recent developments in the field of anticancer platinum complexes. Recent Patents Anticancer Drug Discov. 2006;1:285-95.
  • 17. Kostova I. Platinum complexes as anticancer agents. Recent Patents Anticancer Drug Discov. 2006;1:1-22.
  • 18. Einhorn LH. Treatment of testicular cancer: a new and improved model. J Clin Oncol. 1990;8:1777-81.
  • 19. Segelov E, Campbell J, Ng M, Tattersall M, Rome R, Free K et al. Cisplatin-based chemotherapy for ovarian germ cell malignancies: the Australian experience. J Clin Oncol. 1994;12:378-84. 20. Chu G. Cellular responses to cisplatin. J Biol Chem. 1994;269:787-90.
  • 21. Yao X, Panichpisal K, Kirtzman N, Nugent K. Cisplatin nephrotoxicity: a review. Am J Med Sci. 2007;334:115-24.
  • 22. Hanigan MH, Lykissa ED, Townsend DM, Ou CN, Barrios R, Lieberman MW. Gama glutamyl transpeptidase-deficient mice are resistant to the nephrotoxic effects of cisplatin. Am J Pathol. 2001;159:1889-94.
  • 23. Hanigan MH, Gallagher BC, Taylor PT Jr, Large MK. Inhibition of gamma-glutamyl transpeptidase activity by acivicin in vivo protects the kidney from cisplatin-induced toxicity. Cancer Res. 1994;54:5925-9.
  • 24. Hanigan MH, Frierson HF Jr. Immunohistochemical detection of g-glutamyl transpeptidase in normal human tissue. J Histochem Cytochem. 1996;44:1101-8.
  • 25. Javadpour N. Multiple biochemical tumor markers in seminoma. Cancer. 1983;52:887-9.
  • 26. Bedük Y, Yurdakul T, Adsan Ö, Yaman LS, Renda N. Testis tümörlerinde multipl serum tümör belirleyicileri (ön rapor). T Klin Araştırma. 1991;9:217-20.
  • 27. Satoh M, Aoki Y, Tohyama C. Protective role of metallothionein in renal toxicity of cisplatinum. Cancer Chemother Pharmacol. 1997;40:358-62.
  • 28. Wainford RD, Weaver RJ, Stewart KN, Brown P, Hawksworth GM. Cisplatin nephrotoxicity is mediated by gamma glutamyltranspeptidase, not via a C-S lyase governed biotransformation pathway. Toxicology. 2008;249:184-93.

Gamma Glutamyl Transpeptidase Effect in Testicular Tumor; Is a New Biomarker Born?

Year 2021, Volume: 23 Issue: 2, 309 - 317, 31.08.2021
https://doi.org/10.24938/kutfd.900045

Abstract

Objective: The aim of this study is to investigate the use of serum gamma-glutamyl transpeptidase level as a biomarker especially in seminomatous subtype disease in testicular tumor patients and to investigate the superiority of biomarkers currently in use, and to examine the role of serum gamma-glutamyl transpeptidase levels in chemotherapy response, maintenance and nephrotoxicity in patients receiving cisplatin-based chemotherapy.
Material and Methods: This study was carried out by retrospectively scanning the data of patients diagnosed with testicular tumor and underwent radical inguinal orchiectomy. Age, tumor histology, subtype and stage, tumor side and size, presence of microlithiasis and testicular intraepithelial neoplasia, tumor size and rete testis invasion in patients with seminoma, presence of lymphovascular invasion and percentage of embryonal cancer in non-seminomatous patients, preoperative and postoperative gamma-glutamyl transpeptidase, alpha feto protein, lactate dehydrogenase and beta human chorionic gonadotropin levels, postoperative treatment (chemotherapy and retroperitoneal lymph node dissection), cisplatin therapy status, and post-therapy serum creatinine levels and chemotherapy response were examined in the study.
Results: Our study was carried out with a total of 96 patients after exclusion criteria were applied. It was observed that the preoperative and postoperative levels of serum gamma-glutamyl transpeptidase value were not correlated with alpha feto protein, lactate dehydrogenase and beta human chorionic gonadotropin in both seminoma and nonseminomatous testicular cancers. Age, tumor histology, seminoma subtype, rete testis invasion in seminoma and tumor size in seminoma were found to be significantly correlated as factors that could predict the level of gamma-glutamyl transpeptidase.
Conclusion: The serum gamma-glutamyl transpeptidase enzyme appears to be a new biomarker independent of current biomarkers in seminoma patients. It has been concluded that it is a biomarker that supports rete testis invasion and tumor being larger than 4 cm which are known as bad risk factors in patients with classical subtype seminoma with advanced age.

Project Number

Yok

References

  • 1. Vaitukaitis JL, Braunstein GD, Ross GT. A radioimmunoassay which specifically measures human chorionic gonadotropin in the presence of human luteinizing hormone. Am J Obstet Gynecol. 1972;113:751.
  • 2. Waldmann TA, Mclntire KR. The use of a radioimmunoassay for alphafetoprotein in the diagnosis of malignancy. Cancer. 1974;34:1510.
  • 3. Javadpour N, Mclntire KR, Waldmann TA. Immunochemical determination of human chorionic gonadotropin (HCG) and alphafetoprotein (AFP) in sera and tumors of patients with testicular cancer. Null Cancer Inst Monogr. 1978;49:209-13.
  • 4. Rosen SW, Javadpour N, Calvert I, Kaminska J. Pregnancy-specific B glycoprotein (SP) is increased in certain non-seminomatous germ cell tumors. J Natl Cancer Inst. 1979;62:1439.
  • 5. Kohn J, Orr AH, McElwain TJ, Bentall M, Peckham MJ. Serum alpha-feto-protein in patients with testicular tumors. Lancet. 1976;2:433-6.
  • 6. Lange PH, Fraley EE. Serum alpha-fetoprotein and human chorionic gonadotropin in the treatment of patients with testicular tumors. Urol Clin Norrh Am. 1977;4:393.
  • 7. Wıllemse P, Sleıjfer D, Schraffordt K, De Bruijn HW, Oosterhuis JW, Brouwers TM et al. Tumor markers in patients with non-seminomatous germ cell tumors of the testis. Oncodeu Biol Med. 1981;2:117-28.
  • 8. Bosl JG, Geller İN, Cirrincione MS, Nisselbaum J, Vugrin D, Whitmore Jr WF et al. Serum tumor markers in patients with metastatic germ cell tumors of the testis. Am J Med. 1983;75:29-35.
  • 9. Perrin P, Ardiet C, Pommatau F. Tumor markers in germinal testis tumors. Acta Urologica Belgica. 1982;53:212-22.
  • 10. Scardino P, Cox H, Waldmann T, Mcintire KR, Mittemeyer B, Javadpour N. The value of serum tumor markers in the staging and prognosis of germ cell tumors of the testis. J Ural. 1977;118:994-9.
  • 11. Fraley E, Lange P, Kennedy B. Germ cell testicular cancer in adults. N Engl J Med. 1979;301:1370-7.
  • 12. Fishman WH, lnglis NR, Stolbach CC, Krant MJ. A serum alkaline phosphatase isoenzyme of human neoplastic cell origin. Cancer Res. 1968;28:150.
  • 13. Wahren B, Holmgren PA, Stigbrand T. Placental alkaline phosphatase, alphafetoprotein and carcinoembryonic antigen in testicular tumors: Tissue typing by means ofcytologic smear. Intl J Cuncer. 1979;24:749.
  • 14. Laishes BA, Ogawa K, Roberts E, Farber E. Gamma-glutamyl transpetidase: A positive marker for cultured rat liver cells derived from putative premalignant and malignant lesions. J Nafl Cancer Inst. 1978;60:1009.
  • 15. Krishnaswamy PR, Tate S, Meister A. Gamma, glutamyl transpeptidase of human seminal fluid. Liye Science. 1977;20:681.
  • 16. Galanski M. Recent developments in the field of anticancer platinum complexes. Recent Patents Anticancer Drug Discov. 2006;1:285-95.
  • 17. Kostova I. Platinum complexes as anticancer agents. Recent Patents Anticancer Drug Discov. 2006;1:1-22.
  • 18. Einhorn LH. Treatment of testicular cancer: a new and improved model. J Clin Oncol. 1990;8:1777-81.
  • 19. Segelov E, Campbell J, Ng M, Tattersall M, Rome R, Free K et al. Cisplatin-based chemotherapy for ovarian germ cell malignancies: the Australian experience. J Clin Oncol. 1994;12:378-84. 20. Chu G. Cellular responses to cisplatin. J Biol Chem. 1994;269:787-90.
  • 21. Yao X, Panichpisal K, Kirtzman N, Nugent K. Cisplatin nephrotoxicity: a review. Am J Med Sci. 2007;334:115-24.
  • 22. Hanigan MH, Lykissa ED, Townsend DM, Ou CN, Barrios R, Lieberman MW. Gama glutamyl transpeptidase-deficient mice are resistant to the nephrotoxic effects of cisplatin. Am J Pathol. 2001;159:1889-94.
  • 23. Hanigan MH, Gallagher BC, Taylor PT Jr, Large MK. Inhibition of gamma-glutamyl transpeptidase activity by acivicin in vivo protects the kidney from cisplatin-induced toxicity. Cancer Res. 1994;54:5925-9.
  • 24. Hanigan MH, Frierson HF Jr. Immunohistochemical detection of g-glutamyl transpeptidase in normal human tissue. J Histochem Cytochem. 1996;44:1101-8.
  • 25. Javadpour N. Multiple biochemical tumor markers in seminoma. Cancer. 1983;52:887-9.
  • 26. Bedük Y, Yurdakul T, Adsan Ö, Yaman LS, Renda N. Testis tümörlerinde multipl serum tümör belirleyicileri (ön rapor). T Klin Araştırma. 1991;9:217-20.
  • 27. Satoh M, Aoki Y, Tohyama C. Protective role of metallothionein in renal toxicity of cisplatinum. Cancer Chemother Pharmacol. 1997;40:358-62.
  • 28. Wainford RD, Weaver RJ, Stewart KN, Brown P, Hawksworth GM. Cisplatin nephrotoxicity is mediated by gamma glutamyltranspeptidase, not via a C-S lyase governed biotransformation pathway. Toxicology. 2008;249:184-93.
There are 27 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Batuhan Ergani 0000-0002-4667-855X

Mehmet Yalçın 0000-0001-9943-7453

Mert Hamza Özbilen 0000-0002-5733-6790

Çağdaş Bildirici 0000-0002-4220-8147

Erkin Karaca 0000-0002-9123-4069

Erkan Aravacık This is me 0000-0002-6791-4566

Hayal Boyacıoğlu 0000-0002-2990-4383

Yusuf Özlem İlbey 0000-0002-1483-9160

Project Number Yok
Publication Date August 31, 2021
Submission Date March 19, 2021
Published in Issue Year 2021 Volume: 23 Issue: 2

Cite

APA Ergani, B., Yalçın, M., Özbilen, M. H., Bildirici, Ç., et al. (2021). TESTİS TÜMÖRÜNDE GAMA GLUTAMİL TRANSPEPTİDAZ ETKİSİ; YENİ BİR BİYOBELİRTEÇ Mİ DOĞUYOR?. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi, 23(2), 309-317. https://doi.org/10.24938/kutfd.900045
AMA Ergani B, Yalçın M, Özbilen MH, Bildirici Ç, Karaca E, Aravacık E, Boyacıoğlu H, İlbey YÖ. TESTİS TÜMÖRÜNDE GAMA GLUTAMİL TRANSPEPTİDAZ ETKİSİ; YENİ BİR BİYOBELİRTEÇ Mİ DOĞUYOR?. Kırıkkale Uni Med J. August 2021;23(2):309-317. doi:10.24938/kutfd.900045
Chicago Ergani, Batuhan, Mehmet Yalçın, Mert Hamza Özbilen, Çağdaş Bildirici, Erkin Karaca, Erkan Aravacık, Hayal Boyacıoğlu, and Yusuf Özlem İlbey. “TESTİS TÜMÖRÜNDE GAMA GLUTAMİL TRANSPEPTİDAZ ETKİSİ; YENİ BİR BİYOBELİRTEÇ Mİ DOĞUYOR?”. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi 23, no. 2 (August 2021): 309-17. https://doi.org/10.24938/kutfd.900045.
EndNote Ergani B, Yalçın M, Özbilen MH, Bildirici Ç, Karaca E, Aravacık E, Boyacıoğlu H, İlbey YÖ (August 1, 2021) TESTİS TÜMÖRÜNDE GAMA GLUTAMİL TRANSPEPTİDAZ ETKİSİ; YENİ BİR BİYOBELİRTEÇ Mİ DOĞUYOR?. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi 23 2 309–317.
IEEE B. Ergani, “TESTİS TÜMÖRÜNDE GAMA GLUTAMİL TRANSPEPTİDAZ ETKİSİ; YENİ BİR BİYOBELİRTEÇ Mİ DOĞUYOR?”, Kırıkkale Uni Med J, vol. 23, no. 2, pp. 309–317, 2021, doi: 10.24938/kutfd.900045.
ISNAD Ergani, Batuhan et al. “TESTİS TÜMÖRÜNDE GAMA GLUTAMİL TRANSPEPTİDAZ ETKİSİ; YENİ BİR BİYOBELİRTEÇ Mİ DOĞUYOR?”. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi 23/2 (August 2021), 309-317. https://doi.org/10.24938/kutfd.900045.
JAMA Ergani B, Yalçın M, Özbilen MH, Bildirici Ç, Karaca E, Aravacık E, Boyacıoğlu H, İlbey YÖ. TESTİS TÜMÖRÜNDE GAMA GLUTAMİL TRANSPEPTİDAZ ETKİSİ; YENİ BİR BİYOBELİRTEÇ Mİ DOĞUYOR?. Kırıkkale Uni Med J. 2021;23:309–317.
MLA Ergani, Batuhan et al. “TESTİS TÜMÖRÜNDE GAMA GLUTAMİL TRANSPEPTİDAZ ETKİSİ; YENİ BİR BİYOBELİRTEÇ Mİ DOĞUYOR?”. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi, vol. 23, no. 2, 2021, pp. 309-17, doi:10.24938/kutfd.900045.
Vancouver Ergani B, Yalçın M, Özbilen MH, Bildirici Ç, Karaca E, Aravacık E, Boyacıoğlu H, İlbey YÖ. TESTİS TÜMÖRÜNDE GAMA GLUTAMİL TRANSPEPTİDAZ ETKİSİ; YENİ BİR BİYOBELİRTEÇ Mİ DOĞUYOR?. Kırıkkale Uni Med J. 2021;23(2):309-17.

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