BEHÇET SENDROMU BULGULARI İLE MEVSİMLER ARASINDAKİ İLİŞKİ

Year 2021, Volume: 23 Issue: 2, 378 - 384, 31.08.2021

Melih Pamukcu , Rabia Aydogan Baykara , Tuğba İzci Duran

https://doi.org/10.24938/kutfd.923931

Abstract

Amaç: Behçet sendromu ülkemizde yaygın olarak görülmekte olan bir hastalıktır ve bu hastalığın tüm komplikasyonlarının ve belirtilerinin şiddetlenmesinin mevsimsel ilişki gösterebileceği düşünülmektedir. Bu çalışmanın amacı Behçet sendromuna bağlı sistemik tutulumlar ile bu tutulumların mevsimsel ilişkisini incelemektir.

Gereç ve Yöntemler: Onsekiz yaşından büyük ve sistemik tutulumu olan 77 hasta bu retrospektif çalışmaya dahil edildi. Hastaların yaşı, cinsiyeti, Behçet sendromu ve sistem tutulumu tarihi bilgileri, C-reaktif protein değeri, eritrosit sedimantasyon hızı, hemoglobin, lökosit, trombosit, nötrofil, lenfosit, albümin, kreatinin değerleri kaydedildi. Behçet sendromuna bağlı sistemik tutulum kaydına ulaşılan hastaların tutulum paternleri, artrit, üveit, derin ven trombozu, üveit + derin ven trombozu, nörobehçet ve enterobehçet olarak gruplara ayrıldı.

Bulgular: Hastaların ortalama yaşı 41.6±9.8 yıl iken, 31 (%40) hasta kadındı. Paterji testi pozitifliği 38 (%49) hastada saptandı. Behçet sendromu sistem tutulumlarının dağılımı incelendiğinde 7 hastada artrit, 36 hastada üveit, 8 hastada derin ven trombozu, 14 hastada üveit ve derin ven trombozu birlikte mevcutken, 10 hastada nörobehçet ve 2 hastada enterobehçet mevcuttu. Behçet sendromu tutulumlarının tanı tarihlerinin mevsimlere göre dağılımı incelendiğinde üveit, derin ven trombozu ve bu iki tutulumun birlikte görüldüğü hastaların ilkbahar ve yaz mevsimlerinde sonbahar ve kış mevsimlerine göre daha yüksek oranda tanı aldığı görüldü (p<0.05).

Sonuç: Behçet sendromunın sistemik etkilerinin tanı alma dönemlerinin, diğer bir deyişle aktivasyon dönemlerinin mevsimlerle anlamlı şekilde ilişkili olduğu saptandı. Bu ilişkinin diğer otoimmün inflamatuar hastalıklarda olduğu gibi Behçet sendromunun da etiyolojisinde yer alan genetik yatkınlığa eşlik eden çevresel faktör etkisi nedeniyle olduğunu düşündürmektedir ve hastaların takibinde bu ilişki göz önünde bulundurulmalıdır.

Keywords

Behçet Sendromu, Mevsimler *, Üveit, Venöz Tromboz

The Relationship Between Behçet's Syndrome Findings and Seasons

Abstract

Objective: Behçet's syndrome is a common disease in our country and it is thought that there may be a seasonal relationship with the exacerbation of all complications and symptoms of this disease. The aim of this study is to examine the seasonal relationship of systemic involvement in Behçet's syndrome.

Material and Methods: Seventy-seven patients older than 18 years old with systemic involvement were included in this retrospective study. Age, gender, history of Behçet's syndrome and system involvement, C-reactive protein value, erythrocyte sedimentation rate, hemoglobin, leukocyte, thrombocyte, neutrophil, lymphocyte, albumin, and creatinine values were recorded. The involvement patterns of patients with systemic involvement record due to Behçet's disease were divided into groups as arthritis, uveitis, deep vein thrombosis, uveitis+ deep vein thrombosis, neurobehçet and enterobehçet.

Results: While the mean age of the patients was 41.6±9.8 years, 31 (40%) of them were female. Pathergy test positivity was found in 38 (49%) patients. When the distribution of Behçet's syndrome system involvement was examined, 7 patients had arthritis, 36 patients had uveitis, 8 patients had deep vein thrombosis, 14 patients had uveitis and deep vein thrombosis, 10 patients had neurobehçet and 2 patients had enterobehçet. When the distribution of diagnosis dates of Behçet's syndrome involvement by seasons was examined, it was seen that patients with uveitis, deep vein thrombosis and with both involvements were diagnosed at a higher rate in spring and summer than in autumn and winter (p<0.05).

Conclusion: It was determined that the diagnosis periods of the systemic effects of Behçet's syndrome, in other words, the activation periods were related to the seasons. This relationship is thought to be due to the environmental factor effect accompanying the genetic predisposition in Behçet's syndrome etiology as in other autoimmune inflammatory diseases, and this relationship should be considered in the follow-up of patients.

Keywords

Behcet Syndrome, Seasons*, Uveitis, Venous Thrombosis

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