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Neurotrophins

Year 2014, Volume: 7 Issue: 1, 47 - 57, 23.07.2014
https://doi.org/10.5578/kvj.7239

Abstract

Neurotrophins Neurotrophins are the family of growth factors polypeptides which regulate the survival and functions of neurons, synaptic plasticity and synaptic function. Members of the neurotrophin family are nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5, neurotrophin-6 and neurotrophin-7. Neurotrophins are synthesized by neurons of central and peripheral nervous system and many cell types of peripheral tissues and are known to have biological effects on the nervous system as well as in numerous tissues apart from of the nervous system. It is postulated that lack in synthesis of neurotrophins are related to increase susceptibility of neurodegenerative diseases. The therapeutic effects of neurotrophins for neurodegenerative disorders are being explored. The aim of this review is to present information about the structures, synthesizing cells, effect mechanisms and functions of neurotrophins.

References

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Nörotrofinler

Year 2014, Volume: 7 Issue: 1, 47 - 57, 23.07.2014
https://doi.org/10.5578/kvj.7239

Abstract

Nörotrofinler, nöronların sağkalımını ve fonksiyonlarını etkileyen, sinaptik fonksiyonu ve sinaptik plastisiteyi kontrol eden polipeptid yapılı büyüme faktör ailesidir. Nörotrofin ailesi üyeleri, sinir büyüme faktörü, beyin kaynaklı nörotrofik faktör, nörotrofin-3, nörotrofin-4/5, nörotrofin-6, ve nörotrofin7’dir. Nörotrofinler, merkezi sinir sistemi, periferal sinir sistemi nöronları ve periferal dokulardaki birçok hücre tipinden sentezlenmektedir ve hem sinir sisteminde hem de sinir sistemi dışındaki pek çok dokuda biyolojik etkiye sahip oldukları bilinmektedir. Nörotrofin sentezindeki yetersizliğin nörodejeneratif hastalıklara duyarlılığın artışı ile ilgili olduğu kabul edilmektedir. Son yıllarda, nörotrofinlerin nörodejeneratif hastalıklarda tedavi edici etkisi araştırılmaktadır. Bu derlemenin amacı nörotrofinlerin yapıları, sentezlendiği hücreler, etki mekanizmaları ve fonksiyonları hakkında bilgi sunmaktır. ●●●

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  • Barres BA, Raff MC, Gaesse F, Bartke I, Dechant G, Barde YA. A crucial role for neurotrophin-3 in oligodendrocyte development. Nature. 1994; 367:371-375.
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  • Brodski C, Schnürch H, Dechant G. Neurotrophin-3 promotes the cholinergic differentiation of sympathetic neurons. PNAS. 2000; 97(17):9683-9688. Chalazonitis A. Neurotrophin-3 in the development of the enteric nervous system. Progress in Brain Research 146:243-263.
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  • Cohen RI, Marmur R, Norton WT, Mehler MF, Kessler JA. Nerve Growth Factor and Neurotrophin-3 Differentially Regulate the Proliferation and Survival of Developing Rat Brain Oligodendrocytes. J Neurosci. 1996; 16(20):6433-6442.
  • Cristofaro B, Stone OA, Caporali A, Dawbarn D, Ieronimakis N, Reyes M, Madeddu P, Bates DO, Emanueli C. Neurotrophin-3 is a novel angiogenic factor capable of therapeutic neovascularization in a mouse model of limb ischemia. Arterioscler Thromb Vasc Biol. 2010; 30:1143-1150.
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  • Dechant G, Barde YA. The neurotrophin receptor p75(NTR): novel functions and implications for diseases of the nervous system. Nat Neurosci. 2002; 5:1131-1136.
  • Defazio RA, Pong K, Knusel B, Walsh JP. Neurotrophin-4/5 Promotes Dendritic Outgrowth and Calcium Currents in Cultured Mesencephalic Dopamine Neurons. J Neurosci. 2000; 99(2):297-304.
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Details

Primary Language Turkish
Journal Section Articles
Authors

Filiz Kazak This is me

Gül Fatma Yarım This is me

Publication Date July 23, 2014
Published in Issue Year 2014 Volume: 7 Issue: 1

Cite

APA Kazak, F., & Yarım, G. F. (2014). Nörotrofinler. Kocatepe Veterinary Journal, 7(1), 47-57. https://doi.org/10.5578/kvj.7239
AMA Kazak F, Yarım GF. Nörotrofinler. kvj. March 2014;7(1):47-57. doi:10.5578/kvj.7239
Chicago Kazak, Filiz, and Gül Fatma Yarım. “Nörotrofinler”. Kocatepe Veterinary Journal 7, no. 1 (March 2014): 47-57. https://doi.org/10.5578/kvj.7239.
EndNote Kazak F, Yarım GF (March 1, 2014) Nörotrofinler. Kocatepe Veterinary Journal 7 1 47–57.
IEEE F. Kazak and G. F. Yarım, “Nörotrofinler”, kvj, vol. 7, no. 1, pp. 47–57, 2014, doi: 10.5578/kvj.7239.
ISNAD Kazak, Filiz - Yarım, Gül Fatma. “Nörotrofinler”. Kocatepe Veterinary Journal 7/1 (March 2014), 47-57. https://doi.org/10.5578/kvj.7239.
JAMA Kazak F, Yarım GF. Nörotrofinler. kvj. 2014;7:47–57.
MLA Kazak, Filiz and Gül Fatma Yarım. “Nörotrofinler”. Kocatepe Veterinary Journal, vol. 7, no. 1, 2014, pp. 47-57, doi:10.5578/kvj.7239.
Vancouver Kazak F, Yarım GF. Nörotrofinler. kvj. 2014;7(1):47-5.

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