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Giardia duodenalis ile Doğal Enfekte Kuzularda Serum 25 (OH) D3 Seviyeleri

Year 2019, Volume 12, Issue 1, 71 - 74, 31.03.2019
https://doi.org/10.30607/kvj.492805

Abstract

Giardia duodenalis kuşlar, reptiller ve bir çok memeli hayvanı enfekte edebilen binükleuslu flagellalı bir protozoondur. Söz konusu patojen insanlarda ve çiftlik hayvanlarında başta olmak üzere şekillenen ishalin en önemli nedenleri arasında yer almaktadır. Çalışmada Giardia duodenalis ile doğal enfekte kuzularda serum 25-hidroksi vitamin D3 seviyelerindeki değişimlerin belirlenmesi amaçlanmıştır. Araştırmanın hayvan materyalini Aydın bölgesinde bulunan yaşları 15-35 günlük arasında her iki cinsiyetten sakız ırkı Giardia duodenalis ile doğal enfekte (n=30), benzer yaş aralığındaki aynı ırktan (n=15) ve her iki cinsiyetten sağlıklı kuzular oluşturdu. Enfekte ve sağlıklı hayvanlardan dışkı örnekleri rektal tuşe yöntemi ile steril dışkı örnekleri, serum 25-hidroksi vitamin D3 seviyelerinin belirlenmesi amacı ile de tekniğine uygun olarak v.jugularisden toplamda 5 ml olacak şekilde kan örnekleri alındı. Dışkı örneklerinden direkt mikroskobik bakı yöntemi ile giardia taraması yapıldı. Elde edilen serum örneklerinden Savant marka flöresan immunoassay cihazı ile 25-OH-D seviyeleri ölçüldü. İstatistiksel analizde Mann-Whitney U testinden yararlanıldı. Sağlıklı ve doğal enfekte hayvanlara ait 25-hidroksi vitamin D3 seviyeleri arasında istatistiksel (p<0,05) anlamlı değişimlerin olduğu belirlendi.

References

  • Astiazaran-Garcia H, Lopez-Teros V, Valencia ME, Vazquez-Ortiz F, Sotelo-Cruz N, Quihui-Cota L. Giardia lamblia infection and its implications for vitamin A liver stores in school children. Annals of Nutrition and Metabolism. 2010;57(3-4): 228-233.
  • Aytuğ CN, Alaçam E, Özkoç Ü, Yalçın BC. Koyun-Keçi Hastalıkları ve Yetiştiriciliği, İstanbul: Teknografik Matbaası, 1990; 212-213.
  • Baljer G, Wieler L. Ätiologie. Pathogenese und Immunprophylaxe der neonatalen Durchfallerkrankungen der Kälber. Vet 1989; 5: 18-26.
  • Bilal T. Koyun-Keçilerin İç Hastalıkları ve Beslenmesi. İstanbul Üniversitesi Yayın No: 4593, İstanbul: Veteriner Fakültesi Yayın No: 24, 2005.
  • Buret AG. Pathophysiology of enteric infections with Giardia duodenalis. Parasite. 2008 ;15(3):261-265.
  • Cordingley FT, Crawford GPM. Giardia infection causes vitamin B12 deficiency. Australian and New Zealand journal of medicine. 1986; 16(1): 78-79.
  • Dignass AU. Mechanisms and modulation of intestinal epithelial repair. Inflamm Bowel Dis. 2001;7: 68 –77.
  • Gaydos J. Giardia and Wildlife South Coop Wild Dis St Br 1998; 14:2.
  • Geurden T, Pohleb H, Sarrea C, Dreesena L, Vercruyssea J, Claerebouta E. The efficacy of a treatment with fenbendazole against an experimental Giardia duodenalis infection in lambs. Small Rum Res. 2011; 96(2-3):211-215.
  • Geurden T, Vercruysse J, Claerebout E. Is giardia a significant pathogen in production animals?. Exp Parasitol. 2009; 124:98-106. Gökçe E, Ünver A, Erdoğan HM. İshalli neonatal kuzularda enterik patojenlerin belirlenmesi. Kafkas Univ Vet Fak Derg.2010; 16:717-722.
  • Hall GA, Jones PW, Morgan JH. Calf diarrhoea. Bovine Medicine, In: Andrews AH. (Editors). Diseases and Husbuandry of Cattle. Berlin: Blackwell, 1996; 154-180.
  • Hassan V, Hassan S, Seyed-Javad P, Ahmad K, Asieh H, Maryam S, Farid F, Siavash A. Association Between Serum 25 (OH) Vitamin D Concentrations and Inflammatory Bowel Diseases (IBDs) Activity. Medical Journal of Malaysia. 2013; 68(1): 34-38.
  • Kong J, Zhang Z, Musch MW, Ning G, Sun J, Hart J, Bissonnette M, Li YC. Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. Am J Physiol Gastrointest Liver Physiol. 2008; 294(1):208-16.
  • Lim WC, Hanauer SB, Li YC. Mechanisms of Disease: Vitamin D and Inflammatory Bowel Disease. Nature Clinical Practice Gastroenterology and Hepatology.2005; 2(2):103-111.
  • Lim WC, Hanauer SB, Li YC. Mechanisms of disease: vitamin D and inflammatory bowel disease. Nature Clin Pract Gastroenterol Hepatol. 2005;2: 308 –315.
  • Loftus EV Jr. Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology. 2004; 126: 1504 –1517.
  • Lunn B, Northrop A. Symposium on ‘parasitism and protein and energy metabolism and animals’. The impact of gastrointestinal parasites on protein-energy malnutrition in man. Proc Nutr Soc.1992;52:101–111.
  • Nerich V, Jantchou P, Boutron-Ruault MC, Monnet E, Weill A, Vanbockstael V, Auleley GR, Balaire C, Dubost P, Rican S, Allemand H, Carbonnel F. Low Exposure to Sunlight is a Risk Factor for Crohn’a Disease. Alimentary Pharmacology and Therapeutics. 2011; 33(8): 940-945.
  • Nicholson I, Dalzell AM, El-Matary W. Vitamin D as a Therapy for Colitis: A Systematic Review. Journal of Crohn’s and Colitis. 2012; 6(4): 405-411.
  • Olson ME, McAllister TA, Deselliers L, Morck DW, Cheng KJ, Buret AG, Ceri H. Effects of Giardiasis on production in a domestic ruminant (lamb) model. Am J Vet Res. 1995; 56:1470-1474.
  • Radostits OM, Gay CC, Hinchcliff KW, Constable PD. Veterinary Medicine, 10th Edition, Philadelphia, USA: Saunders Elsevier Ltd, 2007.
  • Read C, Walters J, Robertson I, Thompson R. Correlation between genotype of Giardia duodenalis and diarrhoea. Int J Parasitol. 2002;32:229–231.
  • Robertson LJ. Giardia and Cryptosporidium infections in sheep and goats: A review of the potential for transmission to humans via environmental contamination. Epidemiol Infect. 2009; 137:913-921.
  • Ruest N, Couture Y, Faubert GM, Girard C. Morphological changes in the jejunum of calves naturally infected with giardia spp. and Cryptosporidium spp. Vet Parasitol. 1997; 69:177-186.
  • Sweeny JP, Jacobson C, Robertson I, Ryan UM. Carcass productivity consequences of trichostrongylid and protozoan parasites in Merino x Suffolk prime lambs in the South West of Western Australia. Conference proceedings: Melbourne, Australia: The International Congress of parasitology (ICOPA); 2010.
  • Talachian E, Bidari A, Noorbakhsh S, Tabatabaei A, Salari F. Serum levels of vitamins A and D, and zinc in children with acute diarrhea: A cross-sectional study. Medical journal of the Islamic Republic of Iran. 2015; 29:200-207.
  • Ulitsky A, Ananthakrishnan AN, Naik A, Skaros S, Zadvornova Y, Binion DG, Issa M. Vitamin D Deficiency in Patients with Inflammatory Bowel Disease. Journal of Parenteral and Enteral Nutrition. 2011;35(3): 308-316.
  • Ural K, Aysul N, Voyvoda H, Ulutas B, Aldemir OS, Eren H. Single dose of secnidazole treatment against naturally occuring Giardia duodenalis infection in Sakiz lambs. Revista MVZ Córdoba. 2014;19(1):4023-4032.
  • Voloc A. Study on Vitamin D and nutritional status in children and adolescents with helminthiases in central Moldova.Curierul medical. 2015; 58(6):22-29.

Levels of Serum 25 (OH) D3 in Naturally Infected Lambs With Giardia duodenalis

Year 2019, Volume 12, Issue 1, 71 - 74, 31.03.2019
https://doi.org/10.30607/kvj.492805

Abstract

Giardia duodenalis is a binuclear flagellated protozoan that can infect birds, reptiles and many mammals. The pathogen is one of the most important causes of diarrhea in humans and farm animals. The aim of this study was to determine the changes in serum 25-hydroxyvitamin D3 levels in naturally infected lambs with Giardia duodenalis. The animal material of the study was used Sakız sheep which had naturally infected with Giardia duodenalis between 15-35 days of age from the Aydın region (n = 30), healthy lambs in the same age range (n = 15) and both sexes. Sterile stool samples with the method of rectal touching of fecal samples from infected and healthy animals, blood samples were obtained in a total of 5 ml of v.jugularis according to the technique in order to determine serum 25-hydroxyvitamin D3 levels. Giardia screening was performed by direct microscopic examination of stool samples. 25-OH-D levels were measured with Savant brand fluorescent immunoassay device from the obtained serum samples. Mann-Whitney U test was used in statistical analysis. Statistically significant changes were observed in 25-hydroxyvitamin D3 levels of healthy and natural infected animals (p <0.05).

References

  • Astiazaran-Garcia H, Lopez-Teros V, Valencia ME, Vazquez-Ortiz F, Sotelo-Cruz N, Quihui-Cota L. Giardia lamblia infection and its implications for vitamin A liver stores in school children. Annals of Nutrition and Metabolism. 2010;57(3-4): 228-233.
  • Aytuğ CN, Alaçam E, Özkoç Ü, Yalçın BC. Koyun-Keçi Hastalıkları ve Yetiştiriciliği, İstanbul: Teknografik Matbaası, 1990; 212-213.
  • Baljer G, Wieler L. Ätiologie. Pathogenese und Immunprophylaxe der neonatalen Durchfallerkrankungen der Kälber. Vet 1989; 5: 18-26.
  • Bilal T. Koyun-Keçilerin İç Hastalıkları ve Beslenmesi. İstanbul Üniversitesi Yayın No: 4593, İstanbul: Veteriner Fakültesi Yayın No: 24, 2005.
  • Buret AG. Pathophysiology of enteric infections with Giardia duodenalis. Parasite. 2008 ;15(3):261-265.
  • Cordingley FT, Crawford GPM. Giardia infection causes vitamin B12 deficiency. Australian and New Zealand journal of medicine. 1986; 16(1): 78-79.
  • Dignass AU. Mechanisms and modulation of intestinal epithelial repair. Inflamm Bowel Dis. 2001;7: 68 –77.
  • Gaydos J. Giardia and Wildlife South Coop Wild Dis St Br 1998; 14:2.
  • Geurden T, Pohleb H, Sarrea C, Dreesena L, Vercruyssea J, Claerebouta E. The efficacy of a treatment with fenbendazole against an experimental Giardia duodenalis infection in lambs. Small Rum Res. 2011; 96(2-3):211-215.
  • Geurden T, Vercruysse J, Claerebout E. Is giardia a significant pathogen in production animals?. Exp Parasitol. 2009; 124:98-106. Gökçe E, Ünver A, Erdoğan HM. İshalli neonatal kuzularda enterik patojenlerin belirlenmesi. Kafkas Univ Vet Fak Derg.2010; 16:717-722.
  • Hall GA, Jones PW, Morgan JH. Calf diarrhoea. Bovine Medicine, In: Andrews AH. (Editors). Diseases and Husbuandry of Cattle. Berlin: Blackwell, 1996; 154-180.
  • Hassan V, Hassan S, Seyed-Javad P, Ahmad K, Asieh H, Maryam S, Farid F, Siavash A. Association Between Serum 25 (OH) Vitamin D Concentrations and Inflammatory Bowel Diseases (IBDs) Activity. Medical Journal of Malaysia. 2013; 68(1): 34-38.
  • Kong J, Zhang Z, Musch MW, Ning G, Sun J, Hart J, Bissonnette M, Li YC. Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. Am J Physiol Gastrointest Liver Physiol. 2008; 294(1):208-16.
  • Lim WC, Hanauer SB, Li YC. Mechanisms of Disease: Vitamin D and Inflammatory Bowel Disease. Nature Clinical Practice Gastroenterology and Hepatology.2005; 2(2):103-111.
  • Lim WC, Hanauer SB, Li YC. Mechanisms of disease: vitamin D and inflammatory bowel disease. Nature Clin Pract Gastroenterol Hepatol. 2005;2: 308 –315.
  • Loftus EV Jr. Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology. 2004; 126: 1504 –1517.
  • Lunn B, Northrop A. Symposium on ‘parasitism and protein and energy metabolism and animals’. The impact of gastrointestinal parasites on protein-energy malnutrition in man. Proc Nutr Soc.1992;52:101–111.
  • Nerich V, Jantchou P, Boutron-Ruault MC, Monnet E, Weill A, Vanbockstael V, Auleley GR, Balaire C, Dubost P, Rican S, Allemand H, Carbonnel F. Low Exposure to Sunlight is a Risk Factor for Crohn’a Disease. Alimentary Pharmacology and Therapeutics. 2011; 33(8): 940-945.
  • Nicholson I, Dalzell AM, El-Matary W. Vitamin D as a Therapy for Colitis: A Systematic Review. Journal of Crohn’s and Colitis. 2012; 6(4): 405-411.
  • Olson ME, McAllister TA, Deselliers L, Morck DW, Cheng KJ, Buret AG, Ceri H. Effects of Giardiasis on production in a domestic ruminant (lamb) model. Am J Vet Res. 1995; 56:1470-1474.
  • Radostits OM, Gay CC, Hinchcliff KW, Constable PD. Veterinary Medicine, 10th Edition, Philadelphia, USA: Saunders Elsevier Ltd, 2007.
  • Read C, Walters J, Robertson I, Thompson R. Correlation between genotype of Giardia duodenalis and diarrhoea. Int J Parasitol. 2002;32:229–231.
  • Robertson LJ. Giardia and Cryptosporidium infections in sheep and goats: A review of the potential for transmission to humans via environmental contamination. Epidemiol Infect. 2009; 137:913-921.
  • Ruest N, Couture Y, Faubert GM, Girard C. Morphological changes in the jejunum of calves naturally infected with giardia spp. and Cryptosporidium spp. Vet Parasitol. 1997; 69:177-186.
  • Sweeny JP, Jacobson C, Robertson I, Ryan UM. Carcass productivity consequences of trichostrongylid and protozoan parasites in Merino x Suffolk prime lambs in the South West of Western Australia. Conference proceedings: Melbourne, Australia: The International Congress of parasitology (ICOPA); 2010.
  • Talachian E, Bidari A, Noorbakhsh S, Tabatabaei A, Salari F. Serum levels of vitamins A and D, and zinc in children with acute diarrhea: A cross-sectional study. Medical journal of the Islamic Republic of Iran. 2015; 29:200-207.
  • Ulitsky A, Ananthakrishnan AN, Naik A, Skaros S, Zadvornova Y, Binion DG, Issa M. Vitamin D Deficiency in Patients with Inflammatory Bowel Disease. Journal of Parenteral and Enteral Nutrition. 2011;35(3): 308-316.
  • Ural K, Aysul N, Voyvoda H, Ulutas B, Aldemir OS, Eren H. Single dose of secnidazole treatment against naturally occuring Giardia duodenalis infection in Sakiz lambs. Revista MVZ Córdoba. 2014;19(1):4023-4032.
  • Voloc A. Study on Vitamin D and nutritional status in children and adolescents with helminthiases in central Moldova.Curierul medical. 2015; 58(6):22-29.

Details

Primary Language Turkish
Subjects Science
Journal Section RESEARCH ARTICLE
Authors

Güzin CAMKERTEN (Primary Author)
AKSARAY ÜNİVERSİTESİ, AKSARAY TEKNİK BİLİMLER MESLEK YÜKSEKOKULU
0000-0003-2732-9490
Türkiye


Hasan ERDOĞAN
ADNAN MENDERES ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ
0000-0001-5141-5108


Deniz Alıç URAL
AYDIN ADNAN MENDERES ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ


İlker CAMKERTEN
AKSARAY ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ


Songül ERDOĞAN
ADNAN MENDERES ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ
0000-0002-7833-5519


Kerem URAL
ADNAN MENDERES ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ

Publication Date March 31, 2019
Published in Issue Year 2019, Volume 12, Issue 1

Cite

Bibtex @research article { kvj492805, journal = {Kocatepe Veterinary Journal}, issn = {1308-1594}, eissn = {2147-6853}, address = {}, publisher = {Afyon Kocatepe University}, year = {2019}, volume = {12}, number = {1}, pages = {71 - 74}, doi = {10.30607/kvj.492805}, title = {Giardia duodenalis ile Doğal Enfekte Kuzularda Serum 25 (OH) D3 Seviyeleri}, key = {cite}, author = {Camkerten, Güzin and Erdoğan, Hasan and Ural, Deniz Alıç and Camkerten, İlker and Erdoğan, Songül and Ural, Kerem} }
APA Camkerten, G. , Erdoğan, H. , Ural, D. A. , Camkerten, İ. , Erdoğan, S. & Ural, K. (2019). Giardia duodenalis ile Doğal Enfekte Kuzularda Serum 25 (OH) D3 Seviyeleri . Kocatepe Veterinary Journal , 12 (1) , 71-74 . DOI: 10.30607/kvj.492805
MLA Camkerten, G. , Erdoğan, H. , Ural, D. A. , Camkerten, İ. , Erdoğan, S. , Ural, K. "Giardia duodenalis ile Doğal Enfekte Kuzularda Serum 25 (OH) D3 Seviyeleri" . Kocatepe Veterinary Journal 12 (2019 ): 71-74 <https://dergipark.org.tr/en/pub/kvj/issue/41700/492805>
Chicago Camkerten, G. , Erdoğan, H. , Ural, D. A. , Camkerten, İ. , Erdoğan, S. , Ural, K. "Giardia duodenalis ile Doğal Enfekte Kuzularda Serum 25 (OH) D3 Seviyeleri". Kocatepe Veterinary Journal 12 (2019 ): 71-74
RIS TY - JOUR T1 - Giardia duodenalis ile Doğal Enfekte Kuzularda Serum 25 (OH) D3 Seviyeleri AU - Güzin Camkerten , Hasan Erdoğan , Deniz Alıç Ural , İlker Camkerten , Songül Erdoğan , Kerem Ural Y1 - 2019 PY - 2019 N1 - doi: 10.30607/kvj.492805 DO - 10.30607/kvj.492805 T2 - Kocatepe Veterinary Journal JF - Journal JO - JOR SP - 71 EP - 74 VL - 12 IS - 1 SN - 1308-1594-2147-6853 M3 - doi: 10.30607/kvj.492805 UR - https://doi.org/10.30607/kvj.492805 Y2 - 2019 ER -
EndNote %0 Kocatepe Veterinary Journal Giardia duodenalis ile Doğal Enfekte Kuzularda Serum 25 (OH) D3 Seviyeleri %A Güzin Camkerten , Hasan Erdoğan , Deniz Alıç Ural , İlker Camkerten , Songül Erdoğan , Kerem Ural %T Giardia duodenalis ile Doğal Enfekte Kuzularda Serum 25 (OH) D3 Seviyeleri %D 2019 %J Kocatepe Veterinary Journal %P 1308-1594-2147-6853 %V 12 %N 1 %R doi: 10.30607/kvj.492805 %U 10.30607/kvj.492805
ISNAD Camkerten, Güzin , Erdoğan, Hasan , Ural, Deniz Alıç , Camkerten, İlker , Erdoğan, Songül , Ural, Kerem . "Giardia duodenalis ile Doğal Enfekte Kuzularda Serum 25 (OH) D3 Seviyeleri". Kocatepe Veterinary Journal 12 / 1 (March 2019): 71-74 . https://doi.org/10.30607/kvj.492805
AMA Camkerten G. , Erdoğan H. , Ural D. A. , Camkerten İ. , Erdoğan S. , Ural K. Giardia duodenalis ile Doğal Enfekte Kuzularda Serum 25 (OH) D3 Seviyeleri. Kocatepe Veterinary Journal. 2019; 12(1): 71-74.
Vancouver Camkerten G. , Erdoğan H. , Ural D. A. , Camkerten İ. , Erdoğan S. , Ural K. Giardia duodenalis ile Doğal Enfekte Kuzularda Serum 25 (OH) D3 Seviyeleri. Kocatepe Veterinary Journal. 2019; 12(1): 71-74.
IEEE G. Camkerten , H. Erdoğan , D. A. Ural , İ. Camkerten , S. Erdoğan and K. Ural , "Giardia duodenalis ile Doğal Enfekte Kuzularda Serum 25 (OH) D3 Seviyeleri", Kocatepe Veterinary Journal, vol. 12, no. 1, pp. 71-74, Mar. 2019, doi:10.30607/kvj.492805

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