Enerjilendirilmiş Oksijen Molekülleri İçeren Bitkisel İçerikli Ürünün Yara İyileşmesi Üzerindeki Etkinliğinin Değerlendirilmesi

Year 2023, Volume: 16 Issue: 2, 195 - 208, 30.06.2023

Nurullah Okumuş , Sevim Feyza Erdoğmuş , Özlem Erdal Altıntaş , Hasan Hüseyin Demirel , Sefa Çelik

Abstract

Son yıllarda, tıbbi ve aromatik bitkilerin kullanımıyla ilgili ileri formülasyon teknolojilerinin gelişmesi ile birlikte bitkisel içerikli medikal ürünlere olan ilgi giderek artmaktadır. Geliştirilen bu ürünler, yara ve yanıkların tedavisini hızlı ve etkili bir şekilde gerçekleştirebilmektedir. Bu çalışmada, ilk kez enerjilendirilmiş oksijen molekülü içeren bitkisel içerikli ürünün yara iyileşme üzerindeki etkinliği in vitro ve in vivo çalışmalar ile değerlendirilmiştir. Çalışma kapsamında, Hypericum perforatum L. tıbbi yağı ve enerjilendirilmiş oksijen molekülü içeren bazın biyolojik etkinliği belirlenmiştir. Bu çalışma sonuçları, enerjilendirilmiş oksijen molekülleri içeren bazın ve Hypericum perforatum L. tıbbi yağının patojen test mikroorganizmaları üzerinde antimikrobiyal etkinliğinin bulunduğunu ve insan dermal fibroblast hücreleri üzerinde toksik bir etkisinin bulunmadığını göstermiştir. Enerjilendirilmiş oksijen molekülü içeren bitkisel içerikli ürünün ikinci derece derin yanıklarda etkili olduğu belirlenmiştir. Ürünün yara iyileştirici etkinliğinin antimikrobiyal, antifungal, antioksidan ve hücre proliferasyonunu artırıcı etkisi sayesinde gerçekleştiği düşünülmektedir. İleride yapılacak klinik çalışmalar doğrultusunda ürün ikinci derece yanıkların tadavisinde kullanılabilme potansiyeline sahiptir.

Keywords

Enerjilendirilmiş oksijen molekülleri, Hypericum perforatum L., Yara iyileşme

Supporting Institution

Afyonkarahisar Sağlık Bilimleri Üniversitesi Bilimsel Araştırma Projeleri Komisyonu

Project Number

19. TEMATİK.002

Evaluation of Effectiveness of the Containing Energized Oxygen Molecules Herbal Product on the Wound Healing

Abstract

In recent years, the interest in herbal medicinal products has been increasing with the development of advanced formulation technologies related to the use of the medicinal and aromatic plants. These developed products are used to treat wounds and burns quickly and effectively. In this study, the effectiveness of containing energized oxygen molecules herbal product on wound healing was evaluated by in vitro and in vivo studies for the first time. Within the scope of the study, the biological activities of Hypericum perforatum L. medicinal oil, energized oxygen molecules base were determined. Results of this study showed that the base containing energized oxygen molecules and the medicinal oil of Hypericum perforatum L. had antimicrobial activity on pathogen test microorganisms and did not have a toxic effect on human dermal fibroblast cells. It has been determined that the herbal product containing energized oxygen molecule is effective in second degree deep burns. It is thought that the wound-healing effect of the product is realized thanks to its antimicrobial, antifungal, antioxidant and cell proliferation-increasing effect. In line with future clinical studies, the product has the potential to be used in the treatment of second-degree burns.

Keywords

Energized oxygen molecules, Hypericum perforatum L., Wound healing

Project Number

19. TEMATİK.002

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