The effects of local climatic conditions are evident in the energy consumption and greenhouse gas emissions calculated by considering the boundary conditions defined according to the climatic regions classified by the degree-day method for Turkey. This study aims to investigate the rate of the cities under specified climate regions achieving energy consumption and greenhouse gas emission values below reference indicator values and evaluate the contradictions among the energy consumption and greenhouse gas emissions of a simulated building with two types of outer wall configurations for different cities classified under the same degree-day region with similar climatic conditions by comparing the variation of the results due to reference indicator values defined in the regulation. The variation due to reference indicator values, non-similar for the cities classified under the same degree-day regions, shows the probable deficiency in the existence of these cities under the inappropriate degree-day regions. The primary energy consumption and greenhouse gas emissions of the same building were calculated using BEP-BUY in 38 provinces, where climatic conditions vary in Turkey. The primary energy consumptions and greenhouse gas emissions calculated for the identical structure under the same climate zone classification were above the reference indicator values the "primary energy consumption" and "greenhouse gas emission" in some provinces of all degree-day regions. The study shows that the outcomes were much lower or higher than the RG value for certain cities in the same categorization. Therefore, this shows that it is necessary to evaluate each RG value specified for the degree-day climatic zones.