Mehmet Akif Ersoy University Journal of Health Sciences Institute 2148-2837 Burdur Mehmet Akif Ersoy University 10.24998/maeusabed.1892924 Veterinary Medicine Veteriner Hekimlik PARVOVİRAL GASTROENTERİTİSLİ KÖPEKLERDE SERUM D VİTAMİNİ DÜZEYLERİ ARAŞTIRILMASI INVESTIGATION OF SERUM VITAMIN D LEVELS IN DOGS WITH PARVOVIRAL GASTROENTERITIS https://orcid.org/0009-0004-4542-6352 Çil Selcan BURDUR MEHMET AKİF ERSOY ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ https://orcid.org/0000-0002-0767-883X Karakurum Mehmet Çağrı Mehmet Akif Ersoy University, Turkey 04 27 2026 2026 02 19 2026 03 25 2026 Copyright © 2013, Mehmet Akif Ersoy University Journal of Health Sciences Institute 2013 Mehmet Akif Ersoy University Journal of Health Sciences Institute

İnsan ve hayvan sağlığı konusunda son yıllarda oldukça popüler olan D vitamini pek çok hastalıkla ilişkilendirilmiş fakat köpek nüfusunda ciddi kayıplara sebep olan, mortalite ve bulaşma yüzdesi yüksek olan Parvoviral Gastroenteritis ile enfekte köpeklerde vitamin ile ilişkilendirilen yeterince çalışmaya rastlanmamıştır. Bu çalışmada Parvoviral Gastroenteritli köpeklerde 25 hidroksi vitamin D3 düzeylerinin ölçülmesi ve vitaminin hastalık üzerindeki etkileri hakkında bilgi sahibi olunması amaçlandı. Çalışmada “I. Parvoviral Gastroenteritli Köpekler” ve “II. Sağlıklı Köpekler” olmak üzere iki grup incelendi. Araştırmada canine parvovirus tip 2 (CPV- 2) pozitif olan, 0-12 aylık, farklı cinsiyet ve ırka sahip öncesinde herhangi bir aşılama yapılmamış bir grup köpek ile 0-12 aylık, farklı cinsiyet ve ırka sahip hastalık belirtisi göstermeyen sağlıklı bir grup köpekten kan örneği alınmıştır. Araştırmaya dâhil edilen köpeklerin her birinin Vena cephalica antebrachii’sinden antikoagülansız serum tüplerine 2 ml kan örneği alınarak santrifüje tabi tutulmuş, ardından radyoimmünoassay yöntemi ile bu örneklerdeki 25 hidroksi vitamin D3 düzeyleri belirlenmiştir. Yapılan bu tez çalışmasında ise CPV ile enfekte köpekler ile sağlıklı köpekler arasındaki serum 25(OH)D3 seviyeleri arasındaki fark istatiksel olarak anlamlı bulunmasa da D vitamini metabolitlerinin bilinen immunmodülatör etkileri göz önüne alındığında Parvoviral Gastroenterit ile olası düşük D vitamini seviyeleri arasında ilişki mümkündür.

Vitamin D has been very popular in human and animal health in recent years. It has been associated with many diseases, but there have not been enough studies on the vitamin in dogs infected with Parvoviral Gastroenteritis, which causes serious losses in the dog population, high mortality, and high transmission rates. In this study, the aim was to measure 25-hydroxyvitamin D3 levels in dogs with Parvoviral Gastroenteritis and to gather information on the effects of vitamin D3 on the disease. In the study, two groups, “I. Dogs with Parvoviral Gastroenteritis” and “II. Healthy Dogs,” were examined. In the study, blood was obtained from a group of 0-12 months old dogs of different sexes and breeds who were positive for canine parvovirus type 2 (CPV-2) that had not been vaccinated before, and a healthy group of dogs 0-12 months of age, of different sexes and breeds, who did not show any signs of disease, sample was taken. 2 ml blood samples were taken from Vena cephalica antebrachii of each of the dogs included in the study into serum tubes without anticoagulant and centrifuged, then 25 hydroxy vitamin D3 levels in these samples were determined by radioimmunoassay method. In this study, although the difference in serum 25(OH)D3 levels between CPV-infected dogs and healthy dogs was not statistically significant, a relationship between Parvoviral Gastroenteritis and possible low vitamin D levels is plausible, given vitamin D metabolites' known immunomodulatory effects.

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