Epithelial-Mesenchymal Transition in Normal Development and Carcinogenesis

Abstract

Epithelial-mesenchymal transition EMT is an important developmental process allowing epithelial cells to loose their epithelial properties and gain mesenchymal characteristics through a series of morphological and biochemical changes. As a result of EMT, compact and ordered epithelial cells become less compact and motile, enabling them to migrate to different sites and generate different tissues during normal development. EMT also contributes to metastasis during carcinogenesis, as the epithelial cells of primary tumors undergoing EMT become invasive and migratory. Understanding the EMT process and its regulation during embryonic development may advance our knowledge on carcinogenesis based on the molecular and cellular similarities between pathological and developmental EMT.

Keywords

• Epithelial-mesenchymal transition,TGF-ß,carcinogenesis,embryonic development

Normal Gelişim Süreci ve Karsinogenezde Epitel-Mezenkimal Dönüşüm

Abstract

Epitel-mezenkimal değişim EMD , bir çok morfolojik ve biyokimyasal değişiklikler sonucu epitel hücrelerinin epitel özelliklerini kaybederek mezenkimal özellikler kazanmalarına sebep olan önemli bir gelişim sürecidir. EMD'nin sonucunda kompakt ve düzenli olan epitel hücreleri normal gelişim sürecinde organizmanın farklı kısımlarına göç ederek bu kısımlarda farklı dokuları oluşturabilmelerini olanaklı kılan daha az kompakt ve hareketli bir yapı kazanırlar. Birincil tümörlerin EMD geçiren epitel hücreleri istilaci ve göç edici özellikler kazandığından, EMD karsinogenez sırasındaki metastaz oluşumuna da katkı sağlamış olur. Patolojik ve normal EMD arasındaki moleküler ve hücresel benzerlikler nedeniyle, normal gelişim sırasında gerçekleşen EMD sürecini ve regülasyonu anlamak karsinogenezi daha iyi anlamamızı sağlayabilir.

Keywords

• epitel-mezenkimal değişim,TGF-ß,karsinogenez,embrionik gelişim

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