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Sepsis associated encephalopathy: A case report and literature review

Year 2017, Volume: 9 Issue: 3, 62 - 65, 01.12.2017

Miruna Florentina Ateş Şevki Şahin Nilgün Çınar Sibel Karşıdağ

Abstract

Sepsis-associated encephalopathy SAE is a central nervous system disorder triggered by sepsis. The pathogenesis of SAE may explain that the entering inflammatory cytokines to cerebral microcirculation after destruction of blood brain barrier during sepsis. Herein, we aimed to review the informations about SIE in the light of neurological findings that occurred after urosepsis in an 85 years old female patient.

Keywords

Sepsis encephalopathy coma brain

References

  • Young GB. Encephalopathy of infection and systemic inflammation. J Clin Neurophysiol 2013;30(5):454-61. 2. Eidelman LA, Putterman D, Putterman C, Sprung CL. The spectrum of septic encephalopathy. Definitions, etiologies, and mortalities. JAMA 1996;14; 275(6):470- 473.
  • Azabou E, Magalhaes E, Braconnier A. Early Standard Electroencephalogram Abnormalities Predict Mortality in Septic Intensive Care Unit Patients. PLoS One 2015; 8;10(10):e0139969.
  • Iwashyna TJ, Ely EW, Smith DM, Langa KM. Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA. 2010;304(16):1787– 94.
  • Sharshar T, Polito A, Checinski A, Stevens RD. Septic- associated encephalopathy - everything starts at a microlevel. Crit Care 2010;14(5):199.
  • Heming N, Mazeraud A, Verdonk F, Bozza FA, Chrétien F, Sharshar T. Neuroanatomy of sepsis-associated encephalopathy. Crit Care 2017;21;21(1):65.
  • Starr ME, Saito H. Sepsis in Old Age: Review of human and animal studies. Aging Dis 2014; 5(2): 126– 136.
  • Zampieri FG, Park M, Machado FB, Azevedo LCP. Sepsis-associated encephalopathy: not just delirium. Clinics (Sao Paulo) 2011; 66(10): 1825–1831.
  • Ringer TM, Hubertus A, Romeike BFM, et al. Neurological Sequelae of Sepsis: I) Septic Encephalopathy. Open Crit Care Med J 2011;4:2-7.
  • Davies NW, Sharief MK, Howard RS. Infection- associated encephalopathies: their investigation, diagnosis, and treatment. J Neurol 2006; 253(7): 833- 845.
  • Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 2008;9(1):46-56
  • Papadopoulos MC, Davies DC, Moss RF, Tighe D, Bennett ED. Pathophysiology of septic encephalopathy: a review. Crit Care Med 2000;28(8):3019–3024.
  • Consales G, De Gaudio AR. Sepsis associated encephalopathy. Minerva Anestesiol 2005;71(1–2):39– 52.
  • Cook R, Cook D, Tilley J, Lee K, Marshall J. Multiple organ dysfunction: baseline and serial component scores. Crit Care Med 2001;29(11):2046-2050.
  • Eidelman LA, Putterman D, Putterman C, Sprung CL. The spectrum of septic encephalopathy. Definitions, etiologies, and mortalities. JAMA 1996;275(6):470– 473.
  • Stubbs DJ, Yamamoto AK, Menon DK. Imaging
  • in sepsis-associated encephalopathy--insights and
  • opportunities. Nat Rev Neurol 2013;9(10):551-561.
  • Calsavara AJC, Nobre V, Barichello T, Teixeira AL.
  • Post-sepsis cognitive impairment and associated risk
  • factors: A systematic review. Aust Crit Care. 2017
  • S1036-7314(17)30251-5.
  • Bhattacharya PK, Gautom D, Nath N, Saikia H.
  • A comparative study to assess the determinants and
  • outcomes of sepsis treated in medical wards and ICU
  • in an Indian teaching hospital. J Clin Diagn Res 2016; 10(6): OC01–OC06.
  • Zenaide PV, Gusmao-Flores D. Biomarkers in septic
  • encephalopathy: a systematic review of clinical studies.
  • Rev Bras Ter Intensiva 2013;25(1):56-62.

Sepsisle ilişkili ensefalopati: Olgu sunumu ve literatürün gözden geçirilmesi

Year 2017, Volume: 9 Issue: 3, 62 - 65, 01.12.2017

Miruna Florentina Ateş Şevki Şahin Nilgün Çınar Sibel Karşıdağ

Abstract

Sepsis ile ilişkili ensefalopati SİE santral sinir sisteminin sepsisle tetiklenen bir bozukluğudur. Patojenezinde sepsis sırasında kan beyin bariyeri hasarı ve serebral mikrodolaşıma inflamatuvar sitokinlerin geçmesi suçlanmaktadır. Burada 85 yaşında kadın hastada ürosepsis sonrası gelişen nörolojik bulguların ışığında SİE’ye ait bilgilerin gözden geçirilmesi amaçlanmıştır.

Keywords

Sepsis ensefalopati koma beyin

References

  • Young GB. Encephalopathy of infection and systemic inflammation. J Clin Neurophysiol 2013;30(5):454-61. 2. Eidelman LA, Putterman D, Putterman C, Sprung CL. The spectrum of septic encephalopathy. Definitions, etiologies, and mortalities. JAMA 1996;14; 275(6):470- 473.
  • Azabou E, Magalhaes E, Braconnier A. Early Standard Electroencephalogram Abnormalities Predict Mortality in Septic Intensive Care Unit Patients. PLoS One 2015; 8;10(10):e0139969.
  • Iwashyna TJ, Ely EW, Smith DM, Langa KM. Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA. 2010;304(16):1787– 94.
  • Sharshar T, Polito A, Checinski A, Stevens RD. Septic- associated encephalopathy - everything starts at a microlevel. Crit Care 2010;14(5):199.
  • Heming N, Mazeraud A, Verdonk F, Bozza FA, Chrétien F, Sharshar T. Neuroanatomy of sepsis-associated encephalopathy. Crit Care 2017;21;21(1):65.
  • Starr ME, Saito H. Sepsis in Old Age: Review of human and animal studies. Aging Dis 2014; 5(2): 126– 136.
  • Zampieri FG, Park M, Machado FB, Azevedo LCP. Sepsis-associated encephalopathy: not just delirium. Clinics (Sao Paulo) 2011; 66(10): 1825–1831.
  • Ringer TM, Hubertus A, Romeike BFM, et al. Neurological Sequelae of Sepsis: I) Septic Encephalopathy. Open Crit Care Med J 2011;4:2-7.
  • Davies NW, Sharief MK, Howard RS. Infection- associated encephalopathies: their investigation, diagnosis, and treatment. J Neurol 2006; 253(7): 833- 845.
  • Dantzer R, O’Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 2008;9(1):46-56
  • Papadopoulos MC, Davies DC, Moss RF, Tighe D, Bennett ED. Pathophysiology of septic encephalopathy: a review. Crit Care Med 2000;28(8):3019–3024.
  • Consales G, De Gaudio AR. Sepsis associated encephalopathy. Minerva Anestesiol 2005;71(1–2):39– 52.
  • Cook R, Cook D, Tilley J, Lee K, Marshall J. Multiple organ dysfunction: baseline and serial component scores. Crit Care Med 2001;29(11):2046-2050.
  • Eidelman LA, Putterman D, Putterman C, Sprung CL. The spectrum of septic encephalopathy. Definitions, etiologies, and mortalities. JAMA 1996;275(6):470– 473.
  • Stubbs DJ, Yamamoto AK, Menon DK. Imaging
  • in sepsis-associated encephalopathy--insights and
  • opportunities. Nat Rev Neurol 2013;9(10):551-561.
  • Calsavara AJC, Nobre V, Barichello T, Teixeira AL.
  • Post-sepsis cognitive impairment and associated risk
  • factors: A systematic review. Aust Crit Care. 2017
  • S1036-7314(17)30251-5.
  • Bhattacharya PK, Gautom D, Nath N, Saikia H.
  • A comparative study to assess the determinants and
  • outcomes of sepsis treated in medical wards and ICU
  • in an Indian teaching hospital. J Clin Diagn Res 2016; 10(6): OC01–OC06.
  • Zenaide PV, Gusmao-Flores D. Biomarkers in septic
  • encephalopathy: a systematic review of clinical studies.
  • Rev Bras Ter Intensiva 2013;25(1):56-62.
There are 28 citations in total.

Details

Primary Language Turkish
Journal Section Case Report
Authors

Miruna Florentina Ateş This is me

Şevki Şahin This is me

Nilgün Çınar This is me

Sibel Karşıdağ This is me

Publication Date December 1, 2017
Published in Issue Year 2017 Volume: 9 Issue: 3

Cite

Vancouver Ateş MF, Şahin Ş, Çınar N, Karşıdağ S. Sepsisle ilişkili ensefalopati: Olgu sunumu ve literatürün gözden geçirilmesi. Maltepe tıp derg. 2017;9(3):62-5.