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Timing of expulsion observed, pain and bleeding after mifepristone and misoprostol – induced abortion

Year 2011, Volume: 3 Issue: 3, 13 - 15, 01.08.2011

Abstract

The objectives of this study were to date exactly the time of onset of pain, expulsion, and bleeding in subjects treated with low – dose 200 mg Mifepristone orally and 400 mcg Misoprostol by mouth as well. Our team did analysis the cramping, expulsion observed and bleeding onset patterns in subjects till to 56 days pregnant who used misoprostol at 48 hours after mifepristone orally. We collected data from patient's symptom diaries, and we divided symptom onset into 3 categories: before misoprostole use, 24 hours following misoprostol, and 48 hours after misoprostol. Of the 200 patients, cramping, expulsion observed, and bleeding onset data were available for 175 87.5 % , but 30 of 175 subjects 17.1 % were not able to identify their embryo, so we excluded from the study. Across all groups, 6 patients 4.13 % observed their product of pregnancy, 37 25.5 % and 49 33.7 % experienced respectively bleeding and cramping before misoprostol use. There were a significantly higher percentage of subjects who experienced early cramping and bleeding between three treatment groups, and this was related to the interval between mifepristone and misoprostol. This percentage was significantly reduced in subjects who experienced cramping and bleeding 48 hours after misoprostol use respectively 8 5.5 % and 10 6.89 % . The incidence of expulsion observed, bleeding, cramping was highest 24 hours after misoprostol use.

References

  • 1. Nuri, B. In: Trageakes, E. ed. Health Care Systems in Transition: Albania Copenhagen: European Observatory on Health Care Systems, 2002;4:60.
  • 2. Herold J, Seither R, Ylli A et al. Reproductive Health Survey, Albania 2002: Preliminary Report, Atlanta, GA,USA. Centre for Disease Control, 2003.
  • 3. World Health Organization. Task Force on Postovulatory methods of Fertility Regulation Comparison of two doses of Mifepristone in combination with misoprostol for early abortion. A randomised trial. Br J Obstet Gynaecol 2000:107;524 – 530.
  • 4. Schaff E, Eisinger S, Stadalius L, et al. Low – dose mifepristone 200 mg and vaginal misoprostol for abortion. Contraception 1999; 59: 1–6.
  • 5. Ulmann, André. “The development of mifepristone: a pharmaceutical drama in three acts”. J Am Med Womens Assoc. 2000; 55: 117–120.
  • 6. Bracken H, Gliozheni O, Manoku N, Moisiu R, Shanon C, TASHA I. et al. Mifepristone medical abortion in Albania: Results from a pilot clinical research study. The European Journal of Contraception and Reproductive Health Care. 2006; 11: 38–46.
  • 7. Winikoff B, Ellertson C, Clark s. Analysis of failure in medical abortion. Contraception 1996; 54: 323-327.
  • 8. Hagri S, Blum J, Gueddana N, et al. Expanding medical abortion in Tunisia: Women’s experience from a multisite expansion study, Contraception 2004; 69: 63–69.

Mifepriston ve misoprostol ile indüklenen abortusta ağrının ve kanamanın başlama zamanı ve abortusun oluşma süresi arasındaki ilişki

Year 2011, Volume: 3 Issue: 3, 13 - 15, 01.08.2011

Abstract

Bu çalışmanın amacı oral, düşük doz 200 mg Mifepristone ve oral 400 mcg Misoprostol ile tedavi edilen hastalarda ağrının tam olarak başlama zamanı, düşüğün meydana geldiği zamanı ve kanama miktarı hakkında bilgileri güncellemektir. Ekibimiz, 56.güne kadar olan gebeliklerde oral mifespriston'dan 48 saat sonra misoprostol alan hastalarda kramplar, düşük zamanı ve kanamanın başlangıç zamanını analiz etti. Hastaların semptom günlüklerinden bilgileri aldık ve semptom başlangıcını 3 kategoriye ayırdık: misoprostol kullanımından önce, misoprostol kullanımından 24 saat sonra, ve misoprostol kullanımından 48 saat sonra. 200 hastadan 175'inde %87,5 kramplar, gözlenen düşük ve kanama başlangıç zamanı ile ilgili bilgiler alınabildi, ancak 175 hastadan 30'u %17,1 embriyoyu tanıyamadıklarından çalışma dışı bırakıldılar. Bütün gruplarda, 6 hasta %4,13 gebelik materyalini gördü, sırasıyla 37 %25,5 ve 49 %33,7 hastanın misoprostol öncesi kanama ve kramp tarzında ağrısı oldu. Tedavi grupları arasında erken kramplar ve kanaması olan hastaların oranı anlamlı olarak yüksek bulundu ve bu durum mifepriston ile misoprostol arasındaki interval ile bağlantılı idi. Kramplar ve kanama misoprostol kullanımından 48 saat sonra belirgin olarak sırayla 8 %5,5 ve 10 %6,89 hastada azaldı. Düşük materyalinin görülmesi, kanama, kramplar, misoprostol kullanımından 24 saat sonra en yüksek oranda görüldü.

References

  • 1. Nuri, B. In: Trageakes, E. ed. Health Care Systems in Transition: Albania Copenhagen: European Observatory on Health Care Systems, 2002;4:60.
  • 2. Herold J, Seither R, Ylli A et al. Reproductive Health Survey, Albania 2002: Preliminary Report, Atlanta, GA,USA. Centre for Disease Control, 2003.
  • 3. World Health Organization. Task Force on Postovulatory methods of Fertility Regulation Comparison of two doses of Mifepristone in combination with misoprostol for early abortion. A randomised trial. Br J Obstet Gynaecol 2000:107;524 – 530.
  • 4. Schaff E, Eisinger S, Stadalius L, et al. Low – dose mifepristone 200 mg and vaginal misoprostol for abortion. Contraception 1999; 59: 1–6.
  • 5. Ulmann, André. “The development of mifepristone: a pharmaceutical drama in three acts”. J Am Med Womens Assoc. 2000; 55: 117–120.
  • 6. Bracken H, Gliozheni O, Manoku N, Moisiu R, Shanon C, TASHA I. et al. Mifepristone medical abortion in Albania: Results from a pilot clinical research study. The European Journal of Contraception and Reproductive Health Care. 2006; 11: 38–46.
  • 7. Winikoff B, Ellertson C, Clark s. Analysis of failure in medical abortion. Contraception 1996; 54: 323-327.
  • 8. Hagri S, Blum J, Gueddana N, et al. Expanding medical abortion in Tunisia: Women’s experience from a multisite expansion study, Contraception 2004; 69: 63–69.
There are 8 citations in total.

Details

Primary Language Turkish
Journal Section Research Article
Authors

İlir Tasha This is me

Nikita Manoku This is me

Donika Beba This is me

Publication Date August 1, 2011
Published in Issue Year 2011 Volume: 3 Issue: 3

Cite

Vancouver Tasha İ, Manoku N, Beba D. Mifepriston ve misoprostol ile indüklenen abortusta ağrının ve kanamanın başlama zamanı ve abortusun oluşma süresi arasındaki ilişki. Maltepe tıp derg. 2011;3(3):13-5.