marmara med j

Marmara Medical Journal

1019-1941 1309-9469

Marmara University

10.5472/marumj.1368360

Surgery (Other)

Cerrahi (Diğer)

A case of granulomatosis of polyangiitis presenting with COVID-19 infection: False-positivity or co-existence?

Kaya

Mehtap

MARMARA ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, ÇOCUK SAĞLIĞI VE HASTALIKLARI ANABİLİM DALI, PEDİATRİK NEFROLOJİ BİLİM DALI Gokce

Ibrahim

MARMARA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF CHILD HEALTH AND DISEASES, PEDIATRIC NEPHROLOGY Guven

Sercin

MARMARA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF CHILD HEALTH AND DISEASES, PEDIATRIC NEPHROLOGY Pul

Serim

MARMARA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF CHILD HEALTH AND DISEASES, PEDIATRIC NEPHROLOGY Alpay

Harika

MARMARA UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF CHILD HEALTH AND DISEASES, PEDIATRIC NEPHROLOGY

09 29 2023

36 3 373 376 11 28 2022 05 18 2023

1988

Marmara Medical Journal

Coronavirus disease 2019 (COVID-19) was declared a global pandemic and a public health emergency worldwide in March 2020.COVID-19 presents with non-specific symptoms of the upper airway and pulmonary system, which can overlap with other diseasesinvolving the respiratory system as granulomatosis with polyangiitis (GPA). Both diseases have high morbidity and mortality ratesand it is important to promptly differentiate and treat them. Real-time reverse transcriptase polymerase chain reaction (RT-PCR)is currently the recommended method for diagnosing COVID-19. Antibody-based tests are used to diagnose both pat and currentCOVID-19 infections.We present a previously healthy thirteen-year-old girl who was admitted with upper airway symptoms and pulmonary involvement,and progressed to acute kidney failure. Laboratory findings showed leukocytosis, anemia, elevated kidney function tests and 2+proteinuria. Computed tomography (CT) of the lungs showed multiple nodules, cavities, and ground-glass opacities (GGOs). Weperformed RT-PCR tests for COVID-19 for three times. Results were all negative, but the COVID-19 immunoglobulin (Ig)M testsent simultaneously was positive. Based on the cytoplasmic antineutrophilic cytoplasmic antibody (c-ANCA) positivity, upper airway,pulmonary, and renal involvement, she was diagnosed as GPA.This report highlights that COVID-19 antibody tests can be false-positive in patients with autoimmune diseases including GPA.

COVID-19 Granulomatosis with polyangiitis False-positive antibody test

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