marmara med j

Marmara Medical Journal

1019-1941 1309-9469

Marmara University

THE ACTIONS OF THE α-MELANOCYTE STIMULATING HORMONE (α-MSH) IN INFLAMMATORY CONDITIONS

Oktar

Berna

Alican

İnci

12 03 2016

14 2 113 118 03 24 2016

1988

Marmara Medical Journal

Inflammation, a localized response to tissue injury, and disorders characterized by inflammation are difficult problems in clinical medicine. This difficulty stems in large part from incomplete understanding of inflammatory processes and their regulation. Recent development of the knowledge of the role of the central nervous system and neuroendocrine system in the host responses has provided a new view of the capacity of neuronal and soluble mediators in these systems to influence inflammation. One of these mediators is the endogenous neuropeptide a-MSH, which is an N-acetyl tridecapeptide derived from the cleavage of a larger precursor molecule, proopiomelanocortin (POMC). It was originally isolated and characterized from the intermediate lobe of the pituitary and it was first recognized by its effect on skin melanophores in lower vertebrates (1).

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