marmara med j

Marmara Medical Journal

1019-1941 1309-9469

Marmara University

10.5472/MMJoa.2803.03

Clinical Sciences

Klinik Tıp Bilimleri

Subklinik hipotiroidide aort elastisitesinin değerlendirilmesi

The evaluation of aortic elasticity in subclinical hypothyroidism

Özkan

Sevil

Tarım

Mehmet

Demirtunç

Refik

Duman

Dursun

11 28 2015

28 3 135 141 11 28 2015

1988

Marmara Medical Journal

Amaç: Bu çalışmada. subklinik hipotiroidili hastalarda aortun elastikiyet özellikleri ve bunların sol ventrikül diyastolik fonksiyonu ile ilişkileri transtorasik ekokardiyografik metod ile araştırıldı. Hastalar ve Yöntemler: Transtorasik ekokardiyografi yapılarak aortun elastikiyet parametreleri olarak aortik strain. beta indeksi ve distensibilite indeksine bakıldı. Bulgular: Kontrol grubu ve subklinik hipotiroidili hasta grubu arasında aortik strain (sırasıyla %9.45’e karşı %5.79. p < 0.001) ve distensibilite (4.64’e karşı 3.02 10-3.cm2.dyn-1. p < 0.005) yönünden anlamlı farklar vardı. Subklinik hipotiroidi grubunda mitral erken diyastolik akım hızı (E) ortalaması (p < 0.05). mitral diyastolik akım hızı/ mitral geç diyastolik akım hızı (E/A) (p < 0.01) kontrol grubu ortalamasına göre anlamlı olarak düşük. mitral geç diyastolik akım hızı ortalaması (A) ve izovolümetrik relaksasyon zamanı ( IVRZ) (p < 0.05) kontrol grubu ortalamasına göre yüksek bulundu. Sonuç: Subklinik hipotiroidili hastalarda aortik stiffness’de artış gözlenmektedir. Subklinik hipotiroidili hastalarda gözlenen diyastolik fonksiyon bozukluğundan esas olarak aortik stiffness artışı sorumlu olabilir.

Objective: In this study we evaluated the elastic properties ofthe aorta in patients with subclinical hypothyroidism and theirrelation with left ventricular diastolic function by transthoracicechocardiography.Patients and Methods: Aortic transthoracic echocardiographywas performed and the aortic elasticity was evaluated using thefollowing parameters; strain, the beta index and distensibility.Results: There was significant difference in terms of aorticstrain (5.79% vs. 9.45% p <0.001) and distensibility (4.64 versus3.02 10-3.cm2. dyn-1. p <0.005) between the control group andpatients with subclinical hypothyroidism group. In the subclinicalhypothyroidism group the average mitral early diastolic velocity(E). (p <0.05) were significantly lower than the mean mitraldiastolic flow velocity / mitral late diastolic flow velocity (E / A)(p <0.01) observed in the control group. and higher than the meanmitral late diastolic flow velocity (A) and isovolumetric relaxationtime (IVRT) (P <0.05) in the control group.Conclusions: In patients with subclinical hypothyroidisman increase in the aortic stiffness was observed. The diastolicdysfunction observed in subclinical hypothyroidism is mainlyresponsible for the increase in the aortic stiffness.Keywords: Aortic stiffness. Subclinical hypothyroidism. Leftventricular diastolic dysfunction

Aortic stiffness Subclinical hypothyroidism Left ventricular diastolic dysfunction

Aortik stiffness. Subklinik hipotiroidizm. Sol ventrikül diyastolik disfonksiyonu

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