Revisiting the former approach: Low-dose dopamine in kidney transplant recipients

Year 2021, , 95 - 100, 31.05.2021

Nurdan Senturk Durmus Arzu Velıoglu Hakki Arıkan Ebru Asıcıoglu Cumhur Yegen Serhan Tuglular

https://doi.org/10.5472/marumj.943134

Abstract

Objective: We aim to evaluate the effects of low-dose dopamine (LDD) infusion (0.5 – 2.5 g/kg/min) on hemodynamic status and
short-term graft function in kidney transplant recipients.
Materials and Methods: Patients who underwent kidney transplantation surgery between January 2007 and December 2016 were
included in the study. Demographic and laboratory data, presence of delayed graft function, and the rates of rejection, graft loss, and
mortality were recorded. The data were compared between patients with and without LDD treatment.
Results: A total of 126 patients were included in the study (M/F:50.8%/49.2%; mean age, 38.94 ± 11.8 years). Ninety-four patients
(74.6%) received living-donor transplants. Fifty-seven patients underwent LDD infusion in the postoperative period (LDD group),
while 69 patients did not receive LDD infusion. Demographic and laboratory data of the patients did not significantly differ between
groups. Nineteen patients in the LDD group experienced delayed graft function (p=0.039). However, these patients tended to be older,
have a longer dialysis period prior to transplantation, deceased and hypertensive donors. There was no significant difference in renal
function at 6 months after transplantation between groups.
Conclusion: Although, LDD infusion increases kidney blood flow,

Keywords

Kidney transplantation, Dopamine, Delayed graft function, Rejection

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