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Effect of nimodipine on vasospasm after experimental subarachnoid hemorrhage in rats

Year 1992, Volume: 5 Issue: 4, 145 - 148, 01.12.1992

Abstract

This experimental vasospasm model was made by giving the autologous blood into the cisterna magna. Later Nimodipine (ND) was administered by intracisternal or subcutaneous (s.c.) way in defined times. After that, in the light microscopic examination, the wall thickness (W), lumen (L) and diameter (D) of basilar artery were measured and diameter/wall thickness (D/W), diameter/lumen (D/L) ratios were studied and compared with control group with SAH.

In the first group, intracisternal ND was administered immediately after experimental SAH, ND doses were

10 pg/kg (n: 5), 20 pg/kg (n:4), and 50 pg/kg (n:5). There was no significant difference in the measurements between study group and control (n:

9). In the second group which received s.c. 100 pg/kg t.i.d. for 72 hours, the wall thickness significantly decreased when compared to control group (p<0.01) but the other parameters did not change.

The double-hemorrhage group which received same

dose (100 pg/kg) of ND showed significant increase in the D/W ratio when compared to matching control group (p<0.01). But there was no change in other parameters.

Electron microscopy was made only in rats with SAH taking 100 pg/kg t.i.d. ND for 72 hours. Ultrastructural changes were endothelial changes, subendothelial blebs, corrugation of lamina elastica interna, endothelial denudation and intracytoplasmic vacuoles in both control group with SAH and ND receiving ones. Intracytoplasmic smooth-muscle vacuoles were less prominent in the rats receiving ND.

These findings may indicate that ND shows its effectiveness on experimental vasospasm by decreasing the wall thickness and preventing some morphologic and ultrastructural changes.

References

  • nihei fl, Kasscll nE, Dougherty DA, Sasaki T. Does vasospasm occur in small plal arteries and arterioles of rabbits? Stroke 1991; 22: 1419- 1425.
Year 1992, Volume: 5 Issue: 4, 145 - 148, 01.12.1992

Abstract

References

  • nihei fl, Kasscll nE, Dougherty DA, Sasaki T. Does vasospasm occur in small plal arteries and arterioles of rabbits? Stroke 1991; 22: 1419- 1425.
There are 1 citations in total.

Details

Subjects Clinical Sciences
Journal Section Reviews
Authors

F. Turan This is me

M. Zarifoğlu This is me

A. Evren This is me

E. Oğul This is me

İ. Bora This is me

Publication Date December 1, 1992
Published in Issue Year 1992 Volume: 5 Issue: 4

Cite

APA Turan, F., Zarifoğlu, M., Evren, A., Oğul, E., et al. (1992). Effect of nimodipine on vasospasm after experimental subarachnoid hemorrhage in rats. Marmara Medical Journal, 5(4), 145-148.
AMA Turan F, Zarifoğlu M, Evren A, Oğul E, Bora İ. Effect of nimodipine on vasospasm after experimental subarachnoid hemorrhage in rats. Marmara Med J. December 1992;5(4):145-148.
Chicago Turan, F., M. Zarifoğlu, A. Evren, E. Oğul, and İ. Bora. “Effect of Nimodipine on Vasospasm After Experimental Subarachnoid Hemorrhage in Rats”. Marmara Medical Journal 5, no. 4 (December 1992): 145-48.
EndNote Turan F, Zarifoğlu M, Evren A, Oğul E, Bora İ (December 1, 1992) Effect of nimodipine on vasospasm after experimental subarachnoid hemorrhage in rats. Marmara Medical Journal 5 4 145–148.
IEEE F. Turan, M. Zarifoğlu, A. Evren, E. Oğul, and İ. Bora, “Effect of nimodipine on vasospasm after experimental subarachnoid hemorrhage in rats”, Marmara Med J, vol. 5, no. 4, pp. 145–148, 1992.
ISNAD Turan, F. et al. “Effect of Nimodipine on Vasospasm After Experimental Subarachnoid Hemorrhage in Rats”. Marmara Medical Journal 5/4 (December 1992), 145-148.
JAMA Turan F, Zarifoğlu M, Evren A, Oğul E, Bora İ. Effect of nimodipine on vasospasm after experimental subarachnoid hemorrhage in rats. Marmara Med J. 1992;5:145–148.
MLA Turan, F. et al. “Effect of Nimodipine on Vasospasm After Experimental Subarachnoid Hemorrhage in Rats”. Marmara Medical Journal, vol. 5, no. 4, 1992, pp. 145-8.
Vancouver Turan F, Zarifoğlu M, Evren A, Oğul E, Bora İ. Effect of nimodipine on vasospasm after experimental subarachnoid hemorrhage in rats. Marmara Med J. 1992;5(4):145-8.