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The efficacy of almitrine bismesylate on hypoxemia, exercise performance and sleep desaturation of patients with severe copd

Year 1993, Volume: 6 Issue: 2, 53 - 58, 01.04.1993

B. Ceyhan T. Çelikel A. S. Fak

Abstract

Almitrine bismesylate (AB), a peripheral chemorecep- tor agonist, has been shown to improve arterial blood gases in patients with chronic obstructive pulmonary disease (COPD). This study was designed to test the efficacy of almitrine bismesylate in patients with COPD. AB was administered 3 mg/kg po bid to 17 patients (12 men, 5 women, mean predicted FEV1%:33%(21-51). Arterial blood gas analysis revealed incline of Pa02 from 55.2111.7 mmHg to

62.7110.4 mmHg and incline of oxygen saturation (Sa02) from 84.319.7% to 89.716.1% (p<0.003, p<0.002) 3 hours after intake of a single dose, 7 patients dropped out of the study. Mean Pa02 increased 10.2 mmHg (p<0.003), mean PaC02 decreased 8.5 mmHg (p<0.003) and oxygen saturation increased 5.9%(p<0.009) 3 months after in 10 patients.

Keywords

Almitrine bismesylate chronic obstructive pulmonary disease

References

  • Melot C. Maege R, Hallemans R, Mois P. Lejeune P. Beneficial effects of almitrine bismesylate on pulmonary gas exchange in COPD. Bur J Resp Dis 1983 ;126(64) : 249-254.

Year 1993, Volume: 6 Issue: 2, 53 - 58, 01.04.1993

B. Ceyhan T. Çelikel A. S. Fak

Abstract

References

  • Melot C. Maege R, Hallemans R, Mois P. Lejeune P. Beneficial effects of almitrine bismesylate on pulmonary gas exchange in COPD. Bur J Resp Dis 1983 ;126(64) : 249-254.
There are 1 citations in total.

Details

Subjects Clinical Sciences
Journal Section Review Makaleler
Authors

B. Ceyhan This is me

T. Çelikel This is me

A. S. Fak This is me

Publication Date April 1, 1993
Published in Issue Year 1993 Volume: 6 Issue: 2

Cite

APA Ceyhan, B., Çelikel, T., & Fak, A. S. (1993). The efficacy of almitrine bismesylate on hypoxemia, exercise performance and sleep desaturation of patients with severe copd. Marmara Medical Journal, 6(2), 53-58.
AMA Ceyhan B, Çelikel T, Fak AS. The efficacy of almitrine bismesylate on hypoxemia, exercise performance and sleep desaturation of patients with severe copd. Marmara Med J. April 1993;6(2):53-58.
Chicago Ceyhan, B., T. Çelikel, and A. S. Fak. “The Efficacy of Almitrine Bismesylate on Hypoxemia, Exercise Performance and Sleep Desaturation of Patients With Severe Copd”. Marmara Medical Journal 6, no. 2 (April 1993): 53-58.
EndNote Ceyhan B, Çelikel T, Fak AS (April 1, 1993) The efficacy of almitrine bismesylate on hypoxemia, exercise performance and sleep desaturation of patients with severe copd. Marmara Medical Journal 6 2 53–58.
IEEE B. Ceyhan, T. Çelikel, and A. S. Fak, “The efficacy of almitrine bismesylate on hypoxemia, exercise performance and sleep desaturation of patients with severe copd”, Marmara Med J, vol. 6, no. 2, pp. 53–58, 1993.
ISNAD Ceyhan, B. et al. “The Efficacy of Almitrine Bismesylate on Hypoxemia, Exercise Performance and Sleep Desaturation of Patients With Severe Copd”. Marmara Medical Journal 6/2 (April 1993), 53-58.
JAMA Ceyhan B, Çelikel T, Fak AS. The efficacy of almitrine bismesylate on hypoxemia, exercise performance and sleep desaturation of patients with severe copd. Marmara Med J. 1993;6:53–58.
MLA Ceyhan, B. et al. “The Efficacy of Almitrine Bismesylate on Hypoxemia, Exercise Performance and Sleep Desaturation of Patients With Severe Copd”. Marmara Medical Journal, vol. 6, no. 2, 1993, pp. 53-58.
Vancouver Ceyhan B, Çelikel T, Fak AS. The efficacy of almitrine bismesylate on hypoxemia, exercise performance and sleep desaturation of patients with severe copd. Marmara Med J. 1993;6(2):53-8.