Year 2017, Volume 30 , Issue 2, Pages 119 - 123 2017-05-14

Salt wasting in two neonates with posterior urethral valves: secondary pseudohypoaldosteronism
Posterior üretral valvlı iki yenidoğanda tuz kaybı: sekonder psödohipoaldosteronizm

Ülger ALTUNTAŞ [1] , İbrahim GÖKCE [2] , Halil TUĞTEPE [3] , Meryem BENZER [4] , Serçin GÜVEN [5] , Nurdan YILDIZ [6] , Harika ALPAY [7]


Secondary pseudohypoaldosteronism (PHA) is a rare condition

that presents with hyperkalemia, hyponatremia, and metabolic

acidosis, which develops due to renal tubular unresponsiveness

to aldosterone. It may be seen in infants with obstructive

uropathy and acute pyelonephritis. Three important reasons of

the aldosterone unresponsiveness of the tubules are early infancy

kidney, obstructive uropathy, and urinary tract infection. Besides

other findings, diagnosis is established with highly increased

plasma aldosterone and renin levels. In infants who present with

hyperkalemia, hyponatremia, and metabolic acidosis, PHA should

be considered in the differential diagnosis of congenital adrenal

hyperplasia. Urinary ultrasonography and urine analysis should be

performed in these patients. Herein, we present two patients with

secondary PHA caused by posterior urethral valves.

Sekonder psödohipoaldosteronizm (PHA), böbrek tübüllerinin

aldosterona duyarsızlığı ile karakterize, hiperkalemi,

hiponatremi ve metabolik asidoz ile kendini gösteren nadir

bir durumdur. Obstrüktif üropatisi olan bebeklerde ve

piyelonefrit sırasında görülebilir. Gelişimi devam eden erken

bebeklik dönemi böbreği, üriner sistemin obstrüktif anomalisi

ve enfeksiyonu sekonder PHA hastalarında tübüluslarda

aldosteron direncine neden olan üç önemli faktördür. Genellikle

hiponatremi, hiperkalemi ve metabolik asidoz ilk bulgulardır,

tetkiklerde belirgin olarak yükselmiş plazma renin ve aldosteron

seviyelerinin saptanması ile tanı konur. Süt çoçuklarında

biyokimyasal incelemede hiperpotasemi, hiponatremi ve

metabolik asidoz saptandığında konjenital adrenal hiperplazi

ayırıcı tanısında PHA göz önünde bulundurulmalı ve bu

hastalarda üriner ultrasonografisi (USG) ve idrar analizi rutin

olarak yapılmalıdır. Bu yazımızda sekonder PHA gelişen

posterior üretral valv (PUV)‘lı iki hasta sunuldu.

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Subjects Medicine
Journal Section Case Reports
Authors

Author: Ülger ALTUNTAŞ

Author: İbrahim GÖKCE

Author: Halil TUĞTEPE

Author: Meryem BENZER

Author: Serçin GÜVEN

Author: Nurdan YILDIZ

Author: Harika ALPAY

Dates

Publication Date : May 14, 2017

Bibtex @case report { marumj344826, journal = {Marmara Medical Journal}, issn = {1019-1941}, eissn = {1309-9469}, address = {}, publisher = {Marmara University}, year = {2017}, volume = {30}, pages = {119 - 123}, doi = {10.5472/marumj.344826}, title = {Salt wasting in two neonates with posterior urethral valves: secondary pseudohypoaldosteronism}, key = {cite}, author = {Altuntaş, Ülger and Gökce, İbrahim and Tuğtepe, Halil and Benzer, Meryem and Güven, Serçin and Yıldız, Nurdan and Alpay, Harika} }
APA Altuntaş, Ü , Gökce, İ , Tuğtepe, H , Benzer, M , Güven, S , Yıldız, N , Alpay, H . (2017). Salt wasting in two neonates with posterior urethral valves: secondary pseudohypoaldosteronism . Marmara Medical Journal , 30 (2) , 119-123 . DOI: 10.5472/marumj.344826
MLA Altuntaş, Ü , Gökce, İ , Tuğtepe, H , Benzer, M , Güven, S , Yıldız, N , Alpay, H . "Salt wasting in two neonates with posterior urethral valves: secondary pseudohypoaldosteronism" . Marmara Medical Journal 30 (2017 ): 119-123 <https://dergipark.org.tr/en/pub/marumj/issue/31489/344826>
Chicago Altuntaş, Ü , Gökce, İ , Tuğtepe, H , Benzer, M , Güven, S , Yıldız, N , Alpay, H . "Salt wasting in two neonates with posterior urethral valves: secondary pseudohypoaldosteronism". Marmara Medical Journal 30 (2017 ): 119-123
RIS TY - JOUR T1 - Salt wasting in two neonates with posterior urethral valves: secondary pseudohypoaldosteronism AU - Ülger Altuntaş , İbrahim Gökce , Halil Tuğtepe , Meryem Benzer , Serçin Güven , Nurdan Yıldız , Harika Alpay Y1 - 2017 PY - 2017 N1 - doi: 10.5472/marumj.344826 DO - 10.5472/marumj.344826 T2 - Marmara Medical Journal JF - Journal JO - JOR SP - 119 EP - 123 VL - 30 IS - 2 SN - 1019-1941-1309-9469 M3 - doi: 10.5472/marumj.344826 UR - https://doi.org/10.5472/marumj.344826 Y2 - 2017 ER -
EndNote %0 Marmara Medical Journal Salt wasting in two neonates with posterior urethral valves: secondary pseudohypoaldosteronism %A Ülger Altuntaş , İbrahim Gökce , Halil Tuğtepe , Meryem Benzer , Serçin Güven , Nurdan Yıldız , Harika Alpay %T Salt wasting in two neonates with posterior urethral valves: secondary pseudohypoaldosteronism %D 2017 %J Marmara Medical Journal %P 1019-1941-1309-9469 %V 30 %N 2 %R doi: 10.5472/marumj.344826 %U 10.5472/marumj.344826
ISNAD Altuntaş, Ülger , Gökce, İbrahim , Tuğtepe, Halil , Benzer, Meryem , Güven, Serçin , Yıldız, Nurdan , Alpay, Harika . "Salt wasting in two neonates with posterior urethral valves: secondary pseudohypoaldosteronism". Marmara Medical Journal 30 / 2 (May 2017): 119-123 . https://doi.org/10.5472/marumj.344826
AMA Altuntaş Ü , Gökce İ , Tuğtepe H , Benzer M , Güven S , Yıldız N , Alpay H . Salt wasting in two neonates with posterior urethral valves: secondary pseudohypoaldosteronism. Marmara Med J. 2017; 30(2): 119-123.
Vancouver Altuntaş Ü , Gökce İ , Tuğtepe H , Benzer M , Güven S , Yıldız N , Alpay H . Salt wasting in two neonates with posterior urethral valves: secondary pseudohypoaldosteronism. Marmara Medical Journal. 2017; 30(2): 119-123.